SAMA HOOLE: Seed oils activate the endocannabinoid system. Result: Increased appetite. Reduced satiety. Hyperphagia. This is why people get munchies from cannabis. CB1 receptor activation. Seed oils do the same thing. Slower. More insidious. Your brain says: "I'm still hungry." Even though you just ate 1,200 calories.

Ever wonder why you can't stop eating? Why you're hungry 2 hours after a meal?

Seed oils activate the endocannabinoid system. They increase 2-AG (2-arachidonoylglycerol).

2-AG is an endocannabinoid. Like THC, but your body makes it. Binds to CB1 receptors in your brain.…

— Sama Hoole (@SamaHoole) November 24, 2025

Ever wonder why you can't stop eating? Why you're hungry 2 hours after a meal? Seed oils activate the endocannabinoid system. They increase 2-AG (2-arachidonoylglycerol). 2-AG is an endocannabinoid. Like THC, but your body makes it. Binds to CB1 receptors in your brain. Result: Increased appetite. Reduced satiety. Hyperphagia. This is why people get munchies from cannabis. CB1 receptor activation. Seed oils do the same thing. Slower. More insidious. Your brain says: "I'm still hungry." Even though you just ate 1,200 calories. The pharmaceutical industry developed CB1 antagonists for weight loss. They worked brilliantly. People lost significant weight. But the drugs caused depression and suicide. They were pulled. Because blocking CB1 affects mood severely. Your brain uses endocannabinoids for appetite AND mood. So here's a better alternative: Eat fatty steak instead of seed oils. When you eat saturated fat, there's no 2-AG surge. No CB1 activation. No artificial hunger. You eat. You're satisfied. You stop.