SAMA HOOLE: The one that induces insulin resistance [seed oils], gives you the munchies, and forces the fat cells to get larger and spill out toxins?

1930 - 1% of American adults were obese.
2018 - 42.4% were obese.

Over that time…

Red meat has gone down 4.4%
Sugar has gone up 38.2%
Seed oils have gone up 1687%

So what turned nearly half the adults obese?

It couldn't be the novel highly processed and inflammatory fat that…

— Sama Hoole (@SamaHoole) October 12, 2025

1930 - 1% of American adults were obese. 2018 - 42.4% were obese. Over that time… Red meat has gone down 4.4% Sugar has gone up 38.2% Seed oils have gone up 1687% So what turned nearly half the adults obese? It couldn't be the novel highly processed and inflammatory fat that we introduced to the human diet over that period. The one that induces insulin resistance, gives you the munchies, and forces the fat cells to get larger and spill out toxins? No, of course not. Must have been the steak.

SAMA HOOLE: Patient: "Doctor, I broke my arm falling off a ladder." Doctor: "Have you considered cutting seed oils?"

Patient: "Doctor, I broke my arm falling off a ladder."

Doctor: "Have you considered cutting seed oils?"

Patient: "My arm is literally bent the wrong way."

Doctor: "Yes, inflammation from linoleic acid weakens bone density. Stop eating rapeseed oil and that won't happen… pic.twitter.com/gP8Q0zwwve

— Sama Hoole (@SamaHoole) October 3, 2025

Patient: "Doctor, I broke my arm falling off a ladder." Doctor: "Have you considered cutting seed oils?" Patient: "My arm is literally bent the wrong way." Doctor: "Yes, inflammation from linoleic acid weakens bone density. Stop eating rapeseed oil and that won't happen again." Patient: "I fell from 15 feet."

Doctor: "Exactly. Oxidised PUFAs affect spatial awareness."

Among other things. So if linoleic acid stays in your tissue for 2-5 years, because it seeks out fatty tissue that means that it stays in your brain tissue for a very long time, and that brain fog that you complain about will be chronic. It also lowers cholesterol, which again affects your brain, nervous system, and reproductive health.

SEED OILS LOWER TESTOSTERONE AND CHOLESTEROL

If you want to find out just why seed oils are so insidious, I have you covered.  https://t.co/nAqRSgIisU

— Sama Hoole (@SamaHoole) October 1, 2025

KEY TAKEAWAYS

Plenty of other plant foods have high levels of linoleic acid, like nuts and seeds. Even pork and chicken fat is 20-25% Omega 6.

Only two diet and lifestyle factors have been shown to have worse outcomes. Smoking, and morbid obesity. Consuming seed oils puts you at worse risk than physical inactivity and heavy drinking.

[Israel is] the poster child for the wonderful Mediterranean diet that was piloted by the aforementioned cholesterol crusader, Ancel Keys. Their diet is low in total fat, low in saturated fat, and high in seed oils. They also happen to be on par with the USA in obesity.

FISH OILS RANK HIGHER ON THE PEROXIDATION INDEX THAN SEED OILS.  Just don’t make them the centrepiece of your diet, and stay the hell away from fish oil capsules. Those will almost certainly be rancid, and they actually rank higher on the peroxidation index than seed oils.

IT'S NOT JUST THE RANCIDITY OF SEED OILS THAT CAUSES THE DAMAGE, BUT A HOST OF OTHER TERRIBLE SIDE EFFECTS.  When seed oils go rancid, the danger isn’t restricted to oxidative damage by free radicals. It also leads to the formation of lipid hydroperoxides. They are highly unstable and rapidly decompose into other dangerous compounds, such as HNE, MDA, acrolein, and carboxyethyl pyrrole.

ALEs are ADVANCED LIPID OXIDATION END PRODUCTS.  . . . Unlike the free radicals, which cause chaos but lead mercifully short lives, ALEs are stable enough to roam around your tissues, exacting permanent damage against your DNA, proteins, and lipids.

SEED OILS LOWER CHOLESTEROL.  The fact that seed oils lower cholesterol should also be a matter of concern. Cholesterol is essential to life, being a precursor for hormones, Vitamin D, and bile acids, as well as stabilising cell membranes. Low cholesterol itself is linked to memory loss, heart failure, depression, aggression, and muscle loss.

Seed oils lower cholesterol by providing phytosterols instead, the plant variants that the human body has no interest in using. The body actively flushes out incoming phytosterols at the expense of absorbing cholesterol, resulting in an artificial denting of your cholesterol numbers.

This means the seed oils don’t normalise cholesterol, they lower it below baseline.

And animal fats don’t cause high cholesterol, they let it return back to the baseline.

Effects Of Seed Oils

• Asthma
• Autoimmune disease
• Mental health disorders
• Diabetes
• Obesity
• Heart disease
• Gut dysfunction
• Inflammation
• Infertility
• Macular degeneration
• Osteoarthritis

SEED OILS ARE EVERYWHERE.  

The Seed Oil Hateful 8

• Canola Oil (Rapeseed)
• Corn Oil
• Soybean Oil
• Cottonseed Oil
• Sunflower Oil
• Safflower Oil
• Grapeseed Oil
• Rice Bran Oil

And despite being nonexistent 150 years ago, they’re everywhere at this point. 

DR. ANNA TOKER: These oils can stick around for TWO YEARS in your body.

Let’s talk seed oils.
They oxidize.
That means they turn toxic inside your body.

Your liver gets hit first (hello, fatty liver),
Then your cells and nerves get the leftovers—
a nice little cocktail of inflammation and long-term damage.

And here’s the kicker…
🥴 These oils can… pic.twitter.com/ifxy6Yf1yp

— drannatoker (@dr_annatoker) July 2, 2025

Let’s talk seed oils. They oxidize. That means they turn toxic inside your body. Your liver gets hit first (hello, fatty liver), Then your cells and nerves get the leftovers— a nice little cocktail of inflammation and long-term damage. And here’s the kicker… These oils can stick around for TWO YEARS in your body. So if you stop consuming them today, you could be free of them by—brace yourself—2027. That’s how sneaky and stubborn they are. Want to know what other “normal” foods are silently wrecking your gut? You need to be in my Gut Check subscription. $5.99/month. For real insight. Real science. And real health. Because what’s your wellness actually worth?

https://drannatoker.com/gut-check-signup… 

DR. SHAWN BAKER: Do seed oils lead to cellulite on the legs?

Do seed oils lead to cellulite on the legs? https://t.co/FUXeXgcCMC

— Dr Shawn Baker 🥩 (@SBakerMD) September 11, 2024

PAUL SALADINO: Seed oils accumulate in some membranes, and we can't get rid of it. Probably causes increased permeability of membranes, it accumulates in mitochondrial membranes

Costco Animal-Based Grocery Haul pic.twitter.com/fRyY6bgL20

— Paul Saladino, MD (@paulsaladinomd) September 6, 2024

My problem with most pork is that it's fed grains, corn, and soy and that corn and soy are very high in linoleic acid and pigs and chickens can't get rid of that linoleic acid, which means the fat of pigs and the fat of chickens fed corn and soy ends up much higher in linoleic acid than the corresponding fat of a wild pig or a wild chicken.  And wild chickens and wild pigs, the amount of linoleic acid is around 5% or 6%, but in domesticated chickens and pigs, you're looking at 15% or 16% linoleic acid.  And excess linoleic acid is the polyunsaturated fatty acid found in seed oils that I'm very worried about for a variety of reasons.  

Learn more about seed oils from Saladino through the podcasts he's done with Georgy Dinkov, Tucker Goodrich, and Jeff Nobbs.  Lots of reasons why seed oils and linoleic acid in seed oils harm humans.  It accumulates in some membranes, and we can't get rid of it.  Probably causes increased permeability of membranes, it accumulates in mitochondrial membranes in the cardiolipin, causing problems with the electron transport chain.  Leads to increased oxidation of LDL, increased oxidized LDL, and has been shown in randomized controlled studies, like the Minnesota Coronary, which is a long study with over 9,000 participants to be linked directly in that randomized controlled trial to higher rates of coronary heart disease, which makes sense when you realize that linoleic acid gets into the LDL particles and causes increased oxidation, etc. 

Will never forget the first time I ate food that included Canola oil.  My heart flipped inside my chest.  Shocked the hell out of me. 

Thanks to Joshua Booth for the above chart.  

DR. SHAWN BAKER: Seed oils are so toxic not even mold will touch it!!

Seed oils are toxic not even mold will touch it!!

Source: @Erb_Family_W pic.twitter.com/vFfo5CB1lD

— Dr Shawn Baker 🥩 (@SBakerMD) August 19, 2024

DR. SHAWN BAKER: They knew vegetable oils were bad decades ago!!

They knew vegetable oils were bad decades ago!!

Source IG: truehumandiet pic.twitter.com/4x5rCwg5OL

— Dr Shawn Baker 🥩 (@SBakerMD) July 2, 2024

AMERICAN HEART ASSOCIATION SAYS SEED OILS ARE HEART HEALTHY!!!

I don’t trust the American Heart Association… pic.twitter.com/n3K3I3rk3A

— Paul Saladino, MD (@paulsaladinomd) May 12, 2024

From Health-Giving Animal Fats to Health-Destroying Seed Oils, the Old Food Switch-a-roo

Hey are you still debating about whether to totally cut all seed oils out of your diet?

Watch this: https://t.co/RLsinvcrvr

— Brian Cates - Political Columnist & Pundit (@drawandstrike) February 14, 2024

Seed oils block protein digestion in the stomach, leading to malnourishment after a full meal, which you see among Americans who overeat; yet lack vital nutrients.

Hello, the unroll you asked for: People love to talk bad about seed oils but not once have a seen… https://t.co/ldDmXbJ7gG Share this if you think it's interesting. 🤖

— Thread Reader App (@threadreaderapp) January 13, 2022

 

I've been told by a doctor fish oil supplements are good for Omega-3 and help inflammation

— Danny (@DMonteban) January 13, 2022

In alphabetical order, these are the seed oils that you want to avoid: Canola oil, Corn oil, Cottonseed oil, Grapeseed oil, Rice bran oil, Safflower oil, Soy oil, and Sunflower oil.  And as you read that list, you might say to yourself, "Wait a minute, isn't Sunflower oil good for you?  I mean it's made from the sun, which is good, right?"  Or what about Rice bran oil?  We've heard so many good things about rice bran, right?  Sort of.  There may be biological benefits derived from some of these seeds in a different form, but in the form of oil due to its processing, it renders them problematic in the biological processes of your body.  

Dr. Catherine Shanahan, otherwise known, as Dr. Cate, writing for Better Nutrition, explains, 

Although they’re usually refined, even unrefined and cold-pressed versions of these oils pose the same health risks, because the oils are naturally rich in polyunsaturated fats (PUFAs). The molecular structure of PUFAs makes them very unstable in the human body, where they generate tremendous amount of free radicals--chaotic reactions that damage cells.  

Free radicals are a normal byproduct of metabolism that our bodies are equipped to handle, but only up to a point. Seed oils produce an onslaught that far exceeds our innate capacity. “Free radicals are bad for us in the same way that radiation is bad for us,” says Dr. Cate. When you eat a lot of PUFA-rich seed oils, she adds, “it’s like you have dirty bombs inside your cells.”

PUFAs are inflammatory and damage the lining of blood vessels, affecting overall circulation and blood flow to the brain, and increasing the risk for heart disease and diabetes.