SAMA HOOLE: [Dr. John Yudkin's] conclusion from decades of research: Sugar, not fat, causes obesity, diabetes, and heart disease.

They don't refute you. They destroy you. --Sama Hoole

1972: Dr. John Yudkin publishes "Pure, White and Deadly."

His conclusion from decades of research: Sugar, not fat, causes obesity, diabetes, and heart disease.

His evidence: Comprehensive, compelling, peer-reviewed.

Response from Ancel Keys and the sugar industry: Destroy him.… pic.twitter.com/eQ6Eer4fyT

— Sama Hoole (@SamaHoole) November 24, 2025

1972: Dr. John Yudkin publishes "Pure, White and Deadly." 

His conclusion from decades of research: Sugar, not fat, causes obesity, diabetes, and heart disease. 

His evidence: Comprehensive, compelling, peer-reviewed. 

Response from Ancel Keys and the sugar industry: Destroy him. 

They didn't refute his research. They attacked his character. 

They called him a charlatan. They questioned his credentials. They excluded him from conferences. They prevented publication of his work. 

Keys personally called him a "mountain of nonsense." 

The sugar industry funded research to contradict him. The vegetable oil industry joined the attack (Yudkin also blamed seed oils). 

By 1980: Yudkin was professionally ruined. His career destroyed. His research ignored. 

He died in 1995, his life's work dismissed as fringe pseudoscience. 

 2009: Researchers begin re-examining his work. Conclusion: "Yudkin was right about everything." 

2014: "Pure, White and Deadly" is republished. Modern scientists read it and realise a brilliant researcher was destroyed for telling the truth 40 years early. 

Today: Every major finding Yudkin published in 1972 has been validated by modern research. 

Sugar does cause metabolic disease. He was right. They destroyed him anyway. 

This is what happens to scientists who threaten profitable industries. 

They don't refute you. They destroy you.

Wow. "They don't refute you. They destroy you." Ain't that the truth. When you think people, meaning a group inside an institution are after, you're not paranoid, you're observant and astute. But don't fall back on your qualifications that they're trying to shake from you, or don't fall back on the hubris that you're more talented or just as talented. You very well may be, may be 5x more talented. But a competition is not what they seek. They don't want an argument that is going to "refute" because anyone can refute their argument. Even biased opinions friends and colleagues can refute their arguments as petty. No, what they want is your destruction. So if you're not prepared to go after them and destroy them first, then I would walk. Because if you do absolutely nothing, and let your past and your past character do the talking for you, they'll destroy you. Sama Hoole makes a very astute point.

BTW, here is a list of toxic effects from sugar.

1.  The toxicity of high blood sugar.

2.  The turbulence of the sugar roller coaster.

3.  Dopamine depletion.

4.  Gut dysfunction.

5.  Inflammation from plant toxins pesticides and Seed oils.

6.  Nutrient depletion.

7.  Insulin resistance.

8.  Fat storage.

9.  Lowered energy levels.

10.  Cancellation of ketosis.

11.  Accelerated aging.