DORIS LOH: EAC is similar to pancreatic, glioblastoma, TNBC, and ovarian cancer in humans. Melatonin at 50 and 100 mg/kg for 14 days shrinks EAC in mice dose-dependently.

IMPRESSIVE: Melatonin at 50 and 100 mg/kg for 14 days shrinks EAC in mice dose-dependently.  --Doris Loh  

Ehrlich ascites carcinoma (EAC) is an extremely aggressive rodent cancer model, killing inoculated rodents in 14 days. EAC is similar to pancreatic, glioblastoma, TNBC, and ovarian cancer in humans. Melatonin at 50 and 100 mg/kg for 14 days shrinks EAC in mice dose-dependently. pic.twitter.com/E5BDq0mzLF

— Doris Loh (@DorissLoh) June 17, 2025

100 mg Melatonin. 

DORIS LOH: If you have brain fog, memory deficit, cognitive dysfunction, sleep loss, and/or symptoms associated with neurodegenerative diseases such as AD and PD, your brain may not be clearing amyloids properly during deep sleep due to inadequate melatonin and ATP.

If you have brain fog, memory deficit, cognitive dysfunction, sleep loss, and/or symptoms associated with neurodegenerative diseases such as AD and PD, your brain may not be clearing amyloids properly during deep sleep due to inadequate melatonin and ATP. https://t.co/KAoXrpLC4t pic.twitter.com/5k8g4TYpYG

— Doris Loh (@DorissLoh) March 26, 2025

100mg Melatonin. 

DORIS LOH: Melatonin reduces cone sensitivity but increases rod sensitivity to light. Why does that matter? It is a story about reducing ATP energy requirements. That means using MEL will get you more vision for less ATP.

The reason is simple. Melatonin reduces cone sensitivity but increase rod sensitivity to light.
Why does that matter? It is a story about reducing ATP energy requirements. That means using MEL will get you more vision for less ATP.
Brilliant, is it not?  https://t.co/0FtHwgSPoK pic.twitter.com/GXCi7mrvnf

— Doris Loh (@DorissLoh) May 17, 2023

DORIS LOH: Clinical evidence for high-dose melatonin at 50 mg/kg in one single dose is safe for patients undergoing liver resection. Melatonin treatment resulted in shorter ICU stay and total hospital stay

Clinical evidence for high-dose melatonin at 50 mg/kg in one single dose is safe for patients undergoing liver resection. Melatonin treatment resulted in shorter ICU stay and total hospital stay. https://t.co/qXaKkYnCBu

(50 mg/kg for a 70 kg person = 3500 mg in one single dose). pic.twitter.com/HPN5ObA6zy

— Doris Loh (@DorissLoh) August 12, 2024

From General Surgery UCSF,

Most hepatectomies are performed for the treatment of hepatic neoplasms, both benign or malignant. Benign neoplasms include hepatocellular adenoma, hepatic hemangioma and focal nodular hyperplasia.The most common malignant neoplasms (cancers) of the liver are metastases; those arising from colorectal cancer are among the most common, and the most amenable to surgical resection. The most common primary malignant tumour of the liver is the hepatocellular carcinoma. Hepatectomy may also be the procedure of choice to treat intrahepatic gallstones or parasitic cysts of the liver.

Liver surgery is safe when performed by experienced surgeons with appropriate technological and institutional support. As with most major surgical procedures, there is a marked tendency towards optimal results at the hands of surgeons with high caseloads in selected centres (typically cancer academic medical centers and transplantation centers).

DORIS LOH: in vivo peer-reviewed study showing exogenous melatonin supplementation increases endogenous production, in addition to normalizing abnormal effects from radiation exposure at the embryonic stage.

An in vivo peer-reviewed study showing exogenous melatonin supplementation increases endogenous production, in addition to normalizing abnormal effects from radiation exposure at the embryonic stage. https://t.co/iC2yrQOIIm pic.twitter.com/aDdnAPAonC

— Doris Loh (@DorissLoh) October 7, 2024

DORIS LOH: Ehrlich ascites carcinoma (EAC) is an extremely aggressive rodent cancer model, killing inoculated rodents in 14 days. EAC is similar to pancreatic, glioblastoma, TNBC, and ovarian cancer in humans. Melatonin at 50 and 100 mg/kg for 14 days shrinks EAC in mice dose-dependently.

Ehrlich ascites carcinoma (EAC) is an extremely aggressive rodent cancer model, killing inoculated rodents in 14 days. EAC is similar to pancreatic, glioblastoma, TNBC, and ovarian cancer in humans. Melatonin at 50 and 100 mg/kg for 14 days shrinks EAC in mice dose-dependently. pic.twitter.com/E5BDq0mzLF

— Doris Loh (@DorissLoh) June 17, 2025

SARS-CoV-2 can upregulate NLRP3 inflammasomes in the brain to induce neurodegenerative disorders, including Parkinson's disease. Melatonin targets NLRP3 inflammasomes. Now you know why MEL is effective against brain fog and memory loss after C-19 infections

SARS-CoV-2 can upregulate NLRP3 inflammasomes in the brain to induce neurodegenerative disorders including Parkinson's disease https://t.co/BxIFXMAPuQ Melatonin targets NLRP3 inflammasomes. Now you know why MEL is effective against brain fog and memory loss after C-19 infections. pic.twitter.com/mFst6FHpN9

— Doris Loh (@DorissLoh) November 10, 2022

High dose melatonin is best for anti-oxidant powers and less for sleep inducement.  But if you're interested, you should read everything about amazing melatonin by Doris Loh.   

DORIS LOH: You can become "smarter" if you have efficient neurons that fire with greater signal strength allowing for faster information processing. Melatonin facilitates neuronal metabolic switching that helps neurons produce more ATP to support neuronal health, performance, and survival.

You can become "smarter" if you have efficient neurons that fire with greater signal strength allowing for faster information processing.
Melatonin facilitates neuronal metabolic switching that helps neurons produce more ATP to support neuronal health, performance, and survival. pic.twitter.com/6Mzb5bXMtA

— Doris Loh (@DorissLoh) March 2, 2025

For over 2 billion years, melatonin was synthesized by archaea and bacteria, the two major domains of life on earth. But it’s function could not be an antioxidant because there was simply not enough oxygen to produce reactive oxygen species that can cause cellular damage. [⅔] pic.twitter.com/wAybsgnp0L

— Doris Loh (@DorissLoh) July 25, 2024

"The Mitochondria Chronicles of Melatonin and ATP: Guardians of Phase Separation," Dorish Loh and Russel J. Reiter, 2016.

Dysfunction in regulation of condensates drive neurodegeneration, cancer, and viral infection. Melatonin is a regulator of biomolecular condensates,

Biomolecular condensates are the holy grail in drug discovery because they allow access to undruggable pathways and targets. Dysfunction in regulation of condensates drive neurodegeneration, cancer, and viral infection. Melatonin is a regulator of biomolecular condensates, 1/2 pic.twitter.com/u05RjNvDAO

— Doris Loh (@DorissLoh) August 18, 2022

The journal Nature explains,

Biomolecular condensates are micron-scale compartments in eukaryotic cells that lack surrounding membranes (they're self-forming) to concentrate proteins and nucleic acids. These condensates are involved in diverse processes, including RNA metabolism, ribosome biogenesis, the DNA damage response and signal transduction. 

Melatonin is a powerhouse compound.  Amazing. 

 

And this the creator made the organizing concept of these organelles pretty clear and fun.

AA can depolarize light and other EMF wavelengths. This is why nature uses it to protect cells from potentially harmful EMFs and why mitochondria express high levels of AA transporters in humans

This is a photograph of ascorbic acid (AA) crystals using crossed polarizing filters. AA can depolarize light and other EMF wavelengths. This is why nature uses it to protect cells from potentially harmful EMFs and why mitochondria express high levels of AA transporters in humans pic.twitter.com/u0GeBJ7a3R

— Doris Loh (@DorissLoh) November 5, 2022

If plants use melatonin to defend against viruses, do you think it odd that animals and humans would not do the same?

Science is uncovering, slowly but surely, all the excellent reasons why melatonin is produced not only in animals, but also plants.

If plants use melatonin to defend against viruses, do you think it odd that animals and humans would not do the same? https://t.co/HlBUG8YFkS pic.twitter.com/Rv3Yx5wJyM

— Doris Loh (@DorissLoh) February 14, 2023

MELATONIN INHIBITS VENOM TOXICITY 100% AT 1:10 RATIO (VENOM: MELATONIN)

This melatonin molecule is proving to be indispensable, anytime, anywhere. pic.twitter.com/6edp7i9A2g

— Doris Loh (@DorissLoh) September 27, 2023

Could be impossible to overdose on Melatonin.

DORIS LOH: on how the phase separation in your eyes which cause cataracts are reversed with melatonin - and how you can stop snake venom

she's showing how the phase separation in your eyes which cause cataracts are reversed with mel - and how you can stop snake venom - https://t.co/Adt80XBbId

— heidi taggart (@TaggartHeidi) May 24, 2024

AMAZING MELATONIN

Concerned about potential cytotoxicity via exposure to snake venom? Look no further than melatonin, the ancient antioxidant that works for every imaginable condition. https://t.co/Up25hk8Gz1
if you are actually bitten by a snake, please seek medical help after you take melatonin pic.twitter.com/udb94NUC9t

— Doris Loh (@DorissLoh) April 14, 2022

LINE1 derepression to cause premature aging syndromes. Melatonin can inhibit LINE1 depression.

SARS-CoV-2 infection can lead to LINE1 derepression resulting in global hypomethylation and genomic instability. https://t.co/RAlGsstZL4. A new peer-reviewed paper identified LINE1 derepression to cause premature aging syndromes. Melatonin can inhibit LINE1 derepression. Amazing! pic.twitter.com/rY6FNPmZLx

— Doris Loh (@DorissLoh) August 11, 2022

MELATONIN COMBINED WITH ATP FIGHTS CATARACTS

When a journal crafts a video to promote your manuscript, you know you are on to something a bit out of the ordinary.  https://t.co/QJ3GFWPxmI

— Doris Loh (@DorissLoh) March 28, 2024

Here is the paper.  

Is there a connection to 5G?

Does 5G exacerbate #LongCovid? In Feb 2020, I presented the hypothesis of membrane depolarization by nnEMF to exacerbate C19 infections. https://t.co/G2mWb58mt6
Is it a coincidence that mitochondrial membranes of leukocytes of LongCOVID patients are also depolarized ? [1/2] pic.twitter.com/A5DR72GWuR

— Doris Loh (@DorissLoh) April 6, 2022

Melatonin is just too smart for most people to get.

A recent-peer-reviewed paper explains just how 'smart' melatonin can be when it comes to being a pro-oxidant to kill cancer cells. Many thanks to authors for including my work on melatonin regulation of prion protein that increases ROS to kill cancer cells.  https://t.co/xPZsc8j5Uh pic.twitter.com/d7fwDJVyHl

— Doris Loh (@DorissLoh) August 23, 2022

Anti-Aging Melatonin to the Rescue

Just published peer-review study found infection by SARS-CoV-2 regardless of disease severity to induce compromised lung physiology equivalent to 15 years of aging. https://t.co/BwPRNc5hta What is decreased in aging? Melatonin. https://t.co/5z8jAyQvCd Can MEL prevent C19 aging?

— Doris Loh (@DorissLoh) September 29, 2022

Be sure to get a second opinion on the anti-aging benefits of melatonin.  Dr. Russel Reiter says, 

I have a supply of melatonin with me at all times.  If I have a stroke or heart attack, I'll immediately load up on melatonin.  Based on what I know, I will take all the melatonin I can, as fast as I can.