DORIS LOH: Clinical evidence for high-dose melatonin at 50 mg/kg in one single dose is safe for patients undergoing liver resection. Melatonin treatment resulted in shorter ICU stay and total hospital stay

Clinical evidence for high-dose melatonin at 50 mg/kg in one single dose is safe for patients undergoing liver resection. Melatonin treatment resulted in shorter ICU stay and total hospital stay. https://t.co/qXaKkYnCBu

(50 mg/kg for a 70 kg person = 3500 mg in one single dose). pic.twitter.com/HPN5ObA6zy

— Doris Loh (@DorissLoh) August 12, 2024

From General Surgery UCSF,

Most hepatectomies are performed for the treatment of hepatic neoplasms, both benign or malignant. Benign neoplasms include hepatocellular adenoma, hepatic hemangioma and focal nodular hyperplasia.The most common malignant neoplasms (cancers) of the liver are metastases; those arising from colorectal cancer are among the most common, and the most amenable to surgical resection. The most common primary malignant tumour of the liver is the hepatocellular carcinoma. Hepatectomy may also be the procedure of choice to treat intrahepatic gallstones or parasitic cysts of the liver.

Liver surgery is safe when performed by experienced surgeons with appropriate technological and institutional support. As with most major surgical procedures, there is a marked tendency towards optimal results at the hands of surgeons with high caseloads in selected centres (typically cancer academic medical centers and transplantation centers).