DORIS LOH: in vivo peer-reviewed study showing exogenous melatonin supplementation increases endogenous production, in addition to normalizing abnormal effects from radiation exposure at the embryonic stage.

An in vivo peer-reviewed study showing exogenous melatonin supplementation increases endogenous production, in addition to normalizing abnormal effects from radiation exposure at the embryonic stage. https://t.co/iC2yrQOIIm pic.twitter.com/aDdnAPAonC

— Doris Loh (@DorissLoh) October 7, 2024

DR. RUSSEL REITER: Melatonin and methylene blue belong in every emergency medical kit.

from Dr. Frank Yap, MD's "Melatonin 101: What You Need to Know, an Interview with Dr. Russel Reiter," September 15, 2024. 

THE HIGHLIGHTS

1)  the most important antioxidant molecules and certainly the most ancient, as it has been part of biological life for over 3 billion years.  It's present in plants and bacteria. 

2)  In the human body — aside from having direct antioxidant effects — it also stimulates the synthesis of glutathione and other important antioxidants like superoxide dismutase and catalase 

3)  the antioxidant activity of melatonin is extremely diverse.

4)  It, in fact, is a very good radical scavenger. There are other radical scavengers — vitamin C, vitamin E, and so forth — but melatonin is superior to those 

5)  it stimulates antioxidative enzymes, especially in mitochondria. Mitochondria are small organelles in the cell that generate the bulk of the free radicals. 

6)  It also removes free radicals and prevents the degeneration of the mitochondria, and why this is so important is because mitochondria are really the center of the action within a cell. 

7)  95% of the melatonin in your body is concentrated within the mitochondria inside the cells.

8)  it appears that under stress, all cells may upregulate their ability to produce melatonin because it's so highly productive 

9)  Anytime your skin is exposed to natural sunlight, however, you can be sure you’re receiving the necessary wavelengths of near-infrared to generate melatonin in your mitochondria. 

10)  there are two types of melatonin in your body: The melatonin produced in your pineal gland, which traverses into your blood, and subcellular melatonin produced inside your mitochondria. 

11)  bright sun exposure around solar noon will indirectly help your pineal gland to produce melatonin during the night. 

12)  If you supplement with melatonin, it will get into your mitochondria and, in fact, do what melatonin does — neutralize free radicals and protect the mitochondria's function.”  

13)  we infused melatonin directly into the heart after the vessel was opened. That reduced cardiac damage by roughly 40%. 

14)  people who are potentially suffering with heart failure because of a damaged heart, they survive better and longer if they are given melatonin on a regular basis. 

15)  Reiter stresses that melatonin has no known toxic threshold, so even though we don’t know what the ideal dose is, we do know it’s safe even at high doses.  

16)  melatonin dosing should follow circadian biology, so around 10 a.m., 4 p.m., and before bed. 

17)  an emergency medical technician goes out and picks up a patient who has clearly a heart attack. I think on-site, immediately, melatonin should be given intravenously rather than orally.  

18)  Methylene blue is well-documented to be highly beneficial for reperfusion injuries. 

19) Melatonin and methylene blue belong in every emergency medical kit. 

20)  excess seed oils are the primary reason why most people are metabolically inflexible.

MELATONIN 101

Melatonin is one of the most important antioxidant molecules and certainly the most ancient, as it has been part of biological life for over 3 billion years. It's present in prokaryotes, which are bacteria, and even in plants. In the human body — aside from having direct antioxidant effects — it also stimulates the synthesis of glutathione and other important antioxidants like superoxide dismutase and catalase. 

Reiter continues: 

“Melatonin has been here forever . . . and its functions have evolved. It has learned to work successfully with other molecules during this three-billion-year evolution. One of the molecules with which it collaborates is glutathione.  But the antioxidant activity of melatonin is extremely diverse.

It, in fact, is a very good radical scavenger. There are other radical scavengers — vitamin C, vitamin E, and so forth — but melatonin is superior to those. But beyond that, it stimulates antioxidative enzymes, especially in mitochondria. Mitochondria are small organelles in the cell that generate the bulk of the free radicals. 

So, it's very important to have a good antioxidant at the level of the mitochondria and melatonin happens to be located and is, in fact, synthesized in the mitochondria. Melatonin scavenges radicals that are generated, but it also stimulates something called sirtuin-3, which activates or deacetylates superoxide dismutase (SOD), which is a very important antioxidative enzyme. 

It also removes free radicals and prevents the degeneration of the mitochondria, and why this is so important is because mitochondria are really the center of the action within a cell. In other words, there's strong evidence that aging, frailty of aging, senescence of cells as we age, relate to molecular damage at the level of the mitochondria, and melatonin seems to be very efficient at protecting mitochondria from that damage.”

Melatonin increases glutathione through a genomic effect on the enzyme that regulates the synthesis of gamma glutamylcysteine synthase, the rate-limiting enzyme in glutathione synthesis. Melatonin activates that enzyme.

Glutathione tends to be found in high concentrations in cells, although some is also found, to a lesser degree, in the extracellular space and the mitochondria. Meanwhile, 95% of the melatonin in your body is concentrated within the mitochondria inside the cells.

Its antioxidant effects are quite diverse, but include preventing free radical generation by enhancing the efficiency of the electron transport chain so fewer electrons leach onto oxygen molecules to generate superoxide antiradical. 

Related: Best Melatonin Gummies for Adults

HOW MITOCHONDRIAL MELATONIN IS GENERATED

Mitochondrial melatonin production is one of the reasons why regular sun exposure is so crucial. Most people understand that sun exposure on bare skin generates vitamin D, courtesy of UVB (ultraviolet B radiation). Few, however, understand that the near-infrared spectrum, when hitting your skin, triggers the generation of melatonin in your mitochondria. 

Reiter explains: 

“Near-infrared radiation penetrates relatively easily the skin and subcutaneous tissues. Every one of those cells contains mitochondria and it appears that near-infrared radiation that is detected, in fact, induces melatonin production. That is important because we now think that melatonin within mitochondria is inducible under a lot of stressful conditions. 

That is not definitively proven, but it appears that under stress, all cells may upregulate their ability to produce melatonin because it's so highly productive. And typically, under stress, free radicals are generated. That is emphasized by the [fact] that in plants ... that happens. 

In other words, if you expose plants to drought, heat, cold, to metal toxicity, the first thing they do is upregulate their melatonin, because all of those situations generate free radicals. And we suspect, although that has not yet been definitely proven, in animal cells as well, including human [cells].”

Identifying the specific wavelengths that trigger melatonin production can be tricky, but generally speaking, it’s likely to be the range between 800 to 1,000 nanometers (nm). This range of near-infrared is invisible and has the ability to penetrate tissue. Visible wavelengths generally do not penetrate the skin, and therefore cannot stimulate your mitochondria.

Anytime your skin is exposed to natural sunlight, however, you can be sure you’re receiving the necessary wavelengths of near-infrared to generate melatonin in your mitochondria. Conversely, when indoors under artificial lighting, you can be certain you’re not getting any. This is because most window glass is low-e and filters out a good portion of the near-infrared, so even sitting near a window is not going to provide you with this benefit.

To compensate for time spent indoors, I use a 250-watt Photo Beam near-infrared bulb from SaunaSpace in my office. I keep it lit when I'm in my office and have my shirt off.  Considering most people spend most of their days indoors, mitochondrial melatonin deficiency is likely rampant. And, since many also do not get enough sleep, they also have a deficiency in the melatonin synthesized in the pineal gland in response to darkness. 

TWO TYPES OF MELATONIN

As hinted at above, there are two types of melatonin in your body: The melatonin produced in your pineal gland, which traverses into your blood, and subcellular melatonin produced inside your mitochondria.

Importantly, the melatonin that your mitochondria produce does not escape your mitochondria. It doesn't go into your blood. So, you're not going to directly increase your blood or serum level of melatonin by sun exposure. But, bright sun exposure around solar noon will indirectly help your pineal gland to produce melatonin during the night.

It is important to understand that your blood level of melatonin is indicative of the melatonin produced in your pineal gland, and/or oral supplementation. Conversely, the melatonin produced by your pineal gland cannot enter into the mitochondria, which is why it is so important to get regular sun exposure. Reiter explains:

“In other words, if you surgically remove the pineal gland from an animal or human, blood levels of melatonin are essentially zero. Not totally zero — I think what happens is that the mitochondria in other cells continue to produce melatonin and some of that leaks out into the blood and gives you a residual — but you have no circadian rhythm.

Melatonin production in the pineal gland is highly rhythmic, depending on the light-dark cycle. This is not true for melatonin in mitochondria. It's not cyclic. It's not impacted by the light-dark environment. It may be affected by certain wavelengths of energy, but it's not affected by the light-dark environment.

So, blood levels are derived from the pineal gland, and this rhythm is very important for setting circadian rhythms. In other words, the function of that melatonin is quite different from the function of the mitochondrial-produced melatonin. It sets the rhythm. Of course, there's always some scavenging by that melatonin as well, but the real scavenging is involved with mitochondrial-produced melatonin.”

ORAL SUPPLEMENTATION NEUTRALIZES FREE RADICALS

Oral supplementation, however, can enter your cells and mitochondria. This is a detail I was wrong about before, and which Reiter clarifies in this interview:

“If you supplement with melatonin, it can also enter cells and get into the mitochondria as well. And that is also very important ... As you age, mitochondrial melatonin diminishes. If you supplement with melatonin, it will get into your mitochondria and, in fact, do what melatonin does — neutralize free radicals and protect the mitochondria's function.” 

MELATONIN IS VITAL TO HEART ATTACK AND STROKE RECOVERY

Considering melatonin’s function within your mitochondria, and the fact that mitochondrial dysfunction is a hallmark of most chronic diseases, it makes sense that melatonin would be helpful against a number of different diseases, including the two most common — heart disease and cancer.

As explained by Reiter, one of the situations that is most devastating for the heart and brain is temporary interruption of the blood supply as a result of a cardiac arrest or stroke. This deprives the tissues of oxygen, and without oxygen, they rapidly deteriorate.

When the blood vessel reopens, which is called reperfusion, and oxygen flows back into those oxygen-deprived cells, this tends to be the time of maximum damage, as loads of free radicals are generated once the blood starts flowing again. 

“There's a large host of studies, including some in humans, where if you give melatonin to induce a heart attack in animals or an accidental heart attack in humans, you can preserve or reduce the amount of cardiac infarct, the amount of damage that occurs in the heart,” Reiter says. 

“There's a very famous cardiologist in the Canary Islands, professor Dominguez-Rodriguez, whom I worked with. And we, about three years ago, published a paper where we infused melatonin directly into the heart after the vessel was opened. That reduced cardiac damage by roughly 40%. 

The other thing that happens in a heart attack is that cardiac cells do not regenerate. Once you lose a cardiac cell, they're done ... and are replaced by fibrous tissue. Of course, fibrous tissue is not contractile, so you get heart failure. 

We just published a paper, again with this same cardiologist, showing that if people who are potentially suffering with heart failure because of a damaged heart, they survive better and longer if they are given melatonin on a regular basis. It's a small study ... but I think that would be a worthwhile field to exploit.” 

DOSE SUGGESTION FOR ACUTE HEART ATTACK

In terms of dosage, it’s difficult to translate doses used in animal studies onto human subjects. In animals, doses between 5 to 10 milligrams per kilogram of body weight are used. In humans, however, the dose is calculated on the basis of surface area rather than on body size, and that significantly reduces the amount of melatonin that you have to give.

That said, Reiter stresses that melatonin has no known toxic threshold, so even though we don’t know what the ideal dose is, we do know it’s safe even at high doses. Additionally, the timing of the dose will be important. The first dose should be taken immediately, but subsequent melatonin dosing should follow circadian biology, so around 10 a.m., 4 p.m., and before bed.

“If I had a heart attack and I had melatonin on my person, I would take melatonin,” Reiter says. “The question is how much? ... This is not a recommendation to any of your patients, but I would not be hesitant about taking 50 milligrams at the time, and some subsequently for the next 24 hours, even during the day. Because you don't want to lose any more heart cells than is absolutely necessary ...

I have suggested this a number of times. In other words, an emergency medical technician goes out, picks up a patient who has clearly a heart attack. I think on site, immediately, melatonin should be given intravenously rather than orally. It'd be difficult to give it orally. That would be my recommendation.”

EMERGENCY MEDICAL KIT FOR ACUTE HEART ATTACK OR STROKE

In cases of an acute heart attack or stroke (which have virtually identical tissue damage mechanisms: one affects the heart and the other your brain), I would also add methylene blue. Methylene blue is well-documented to be highly beneficial for reperfusion injuries, (2) especially if you do it right at the beginning of the event, because it augments cytochromes to allow the continued production of ATP even without the use of oxygen. 

Melatonin and methylene blue belong in every emergency medical kit. In cases of an acute heart attack or stroke, melatonin can help limit the damage, while methylene blue augments cytochromes to allow the continued production of ATP even without the use of oxygen, which also helps minimize cell death and tissue damage.

So, together, methylene blue and melatonin could act as a one-two punch if you've got a stroke or heart attack. They really should be part of every emergency kit.

As an interesting side note, melatonin can also be useful in people with Type 2 diabetes. Reiter notes he has diabetic colleagues who take 1 gram of melatonin daily to counteract the free radical damage caused by hyperglycemia. Keep in mind that melatonin does not treat the cause of the diabetes. It only helps to counteract the damage being caused.

HALF-LIFE AND BIOAVAILABILITY OF MELATONIN  

The half-life of melatonin in the blood is only about 40 minutes. Within cells, the half-life varies according to the level of oxidative stress present. If oxidative stress is high, the melatonin is destroyed much faster; if oxidative stress is low, it remains within the cell much longer.

Reiter also notes that in addition to being a free radical scavenger, all of melatonin’s metabolic kin — its active metabolites, such as N-acetyl-5-methoxytryptamine — are also excellent scavengers. While quickly used up in the presence of high oxidative stress, melatonin is also rapidly taken up when used orally, hence the suggestion to take multiple doses spread out.

Vitamatic 2 Packs Melatonin 20mg Liquid Drops - 2 Fluid Ounce (59ml) - Natural Berry Flavor - for Adults - Non-GMO - Vegetarian Supplement https://t.co/Qr51DdfsK9 via @amazon

— St. Michael, the Archangel (@aveng_angel) September 20, 2024

Melatonin also comes in suppositories of 200mgs. 

Ideally, you’d want to use sublingual or intravenous melatonin, because it’ll enter your bloodstream much faster. Another option is to make your own rectal suppositories. If you swallow it, it needs to pass through and be metabolized by your liver.

MELATONIN IS ALSO A POTENT ANTIVIRAL 

In addition to its antioxidant potency, melatonin also has antiviral capacity. These two features combined is thought to be why it’s been so useful against COVID-19. 

“I'm going to give you a very specific example,” Reiter says. “Here's a local physician, Dr. Richard Neil, whom I have known for a number of years. When COVID-19 became common, he called me, we discussed it, he started giving 1 mg per kilogram of body weight (once a day) for about 5 days, at the time of diagnosis. He has now treated more than 2,000 patients, very successfully, with melatonin.

The importance of melatonin in reference to COVID is that it is not specifically for [the original Wuhan strain]. The variants, Delta, Omicron, they're viruses we think will respond. We currently have a paper in press where we showed that in animals, Zika virus toxicity is also prevented by melatonin, and we've checked four different coronaviruses in pigs.

That paper also shows that melatonin prevents the damage — the consequence — of those viruses.  I think [melatonin] is generally a quite good antiviral agent and should be considered useful. When President Trump was hospitalized with COVID-19, one of the molecules he was given was melatonin. Obviously, the physicians treating him knew this literature.”

So, to summarize, if you have symptoms of COVID-19, you could consider taking oral or sublingual melatonin 30 to 45 minutes before bedtime, first thing in the morning, at 10 a.m., and again at 4 p.m. You clearly want to avoid it a few hours before and after solar noon, as taking supplementation during that time will likely impair pineal nighttime melatonin secretion.

Reiter points out that slow-release melatonin has not been widely studied, and he generally doesn’t recommend it for that reason. 

MELATONIN FOR CANCER

Melatonin can also be useful in the prevention and treatment of cancer.  Reiter explains: 

“Cancer cells are clever. They do everything they can to permit their continued survival.  It seems counterintuitive, but what they do is prevent pyruvate from entering the mitochondria, and that reduces ATP production. But as a consequence of doing that, they accelerate something called glycolysis and that's very inefficient in producing ATP, but it does it very rapidly. So, then they have sufficient energy.

The importance of preventing pyruvate from entering the mitochondria, we now think is the fact that pyruvate is a precursor to something called acetyl coenzyme A. Acetyl coenzyme A is a cofactor for the enzyme that regulates melatonin production in the mitochondria.

So, by eliminating or preventing pyruvate from getting into the mitochondria, [the cancer cells] prevent or reduce melatonin production, because they don't allow the necessary cofactor to be produced. In other words, we predicted about four years ago that, in fact, the mitochondria of cancer cells would produce less melatonin.

We have subsequently shown that in two studies, both uterine cancers. Clearly, melatonin levels and the activity of the enzymes in the mitochondria of these types of cancer cells are at least about half what they would normally be. The prevention of pyruvate into the mitochondria, that's Warburg-type metabolism.

The other thing is the pyruvate is metabolized into lactic acid. It escapes the cell and produces an acidic environment for the cancer cell, and cancer cells like that acidic environment. So, if you can reduce the Warburg-type metabolism, you may be able to limit the growth of cancer cells and perhaps also the metastasis
 . . . 
Some cancer cells may only be part-time cancerous because [during nighttime] when they have high melatonin, then they avoid Warburg-type metabolism. The interesting thing about Warburg-type metabolism [is that] . . . many pathological cells, inflammatory cells, cells that are affected by amyloid beta in the brain, exhibit this specific type metabolism . . .

And we know that inflammatory cells — M2 and M1 inflammatory cells — can be converted back and forth by melatonin. The inflammatory cells can be prevented by giving them melatonin [because of] its effect on Warburg-type metabolism. So, Warburg type metabolism is common in many, many pathological cells.”

THE LINK BETWEEN METABOLIC FLEXIBILITY, MELATONIN, AND CANCER

One of the reasons why cancer is so prevalent likely has to do with the fact that 93% of Americans are metabolically inflexible (JACC 2022) and cannot seamlessly transition between burning carbs and fats for fuel. Glucose (sugar) is one of the primary fuels that most people have. Glucose has six carbons and is metabolized into pyruvate, which is a three-carbon molecule. Pyruvate, in turn, is metabolized in the mitochondria to acetyl-CoA.

The reason the Warburg-Effect works is that pyruvate dehydrogenase kinase (PDK) inhibits the inflow of pyruvate into the mitochondria, so it cannot be converted into acetyl-CoA, and acetyl-CoA is not only needed in the production of melatonin but is also used to efficiently produce ATP in the mitochondria and is how glucose is used in the mitochondria.

Another source of acetyl-CoA is beta oxidation of fats, which breaks down the fat to the two-carbon molecule acetyl-CoA, which enters the mitochondria as an active transport molecule, courtesy of MCT (mono carboxylase transporter). My point here is that when you are metabolically inflexible, the Warburg Effect becomes massive. But if you're cardiometabolically healthy and can burn fat, you can effectively bypass that defect.

Prior to my interview with Reiter, I certainly knew that limiting carbs and preventing the Warburg effect was important in cancer treatment, but I hadn’t realized that one of the metabolic byproducts of acetyl-CoA was needed to produce melatonin. So, being metabolically flexible not only impairs the Warburg effect but also supplies melatonin to combat the excessive oxidative stress in cancer.

This is why I would strongly encourage each and every one of you to regularly engage in two activities the rest of your life. First, expose as much of your skin as you can to an hour of sunshine a day around solar noon.

Second, you have to eliminate all seed oils from your diet, as excess seed oils are the primary reason why most people are metabolically inflexible. While the average person’s consumption of these oils is around 25% to 30% of total daily calories, it should only be about 1% to 2% (mine is 1.5%).

WORD OF CAUTION

Just be careful, though, as using high-dose melatonin long term could be a prescription for disaster. This is because doses of over 5 to 10 mg are likely to draw out heavy metals like mercury and unless you are on a good detoxification program and using a sauna regularly these heavy metals could cause biological damage.

😯 When taken in Mega doses, MELATONIN has amazing anti-inflammatory & healing effects. Lowered mortality 93% in Covid. Also lowers death in Pneumonia, Sepsis, & more.

😯 When taken in Mega doses, MELATONIN has amazing anti-inflammatory & healing effects. Lowered mortality 93% in Covid. Also lowers death in Pneumonia, Sepsis, & more.

One study even showed 1000mg Melatonin stabilized disease progression in 54% of Very advanced CANCER cases. 👀 pic.twitter.com/9QxhMR8pG5

— Natural Immunity FTW (@NaturallyFTW) April 8, 2024

MELATONIN COMBINED WITH ATP FIGHTS CATARACTS

When a journal crafts a video to promote your manuscript, you know you are on to something a bit out of the ordinary.  https://t.co/QJ3GFWPxmI

— Doris Loh (@DorissLoh) March 28, 2024

Here is the paper.  

Melatonin has been shown to treat breast, colon, lung, hepatobiliary, ovarian and prostate cancers - which just happen to also be the same cancers that show up after Pfizer or Moderna COVID-19 mRNA Vaccination

Dr. William Makis, Oncologist and Immunologist: C19 Vaccine-Induced “Turbo Cancers” May Be Treatable With Melatonin:
"Melatonin has been proven to regulate oncogenic miRNAs in a number of cancers, but can it regulate Pfizer’s or Co-miRNA-ty’s oncogenic miRNAs?
Melatonin has been… pic.twitter.com/GgoZ0lrVOi

— Robin Monotti (@robinmonotti) October 13, 2023

MELATONIN INHIBITS VENOM TOXICITY 100% AT 1:10 RATIO (VENOM: MELATONIN)

This melatonin molecule is proving to be indispensable, anytime, anywhere. pic.twitter.com/6edp7i9A2g

— Doris Loh (@DorissLoh) September 27, 2023

Could be impossible to overdose on Melatonin.

" broccoli seedlings closest to the Wi-Fi router grew away from the router. Plants began to several small plants begin to die and mold developed in those Petri plates"

🚩 STUDY - WiFi negatively affects plant growth & health.

Probably does the same to us...

The plants try to get away from it...are they smarter than we are?! pic.twitter.com/6L4BHA0Rog

— Natural Immunity FTW (@NaturallyFTW) August 14, 2023

Check out Abstract #2.  Not only is Melatonin neuroprotective, but so is iodine and so is liquid chlorophyll. 

Food Remedies: MELATONIN: For neuro-protection, not just sleep in... https://t.co/wMxGsTQZ8z

— St. Michael, the Archangel (@aveng_angel) August 15, 2023

ABSTRACT #2 

Both in vitro and in vivo, melatonin was effective to prevent oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of AD, PD and HD. These effects are seen at doses 2-3 orders of magnitude higher than those required to affect sleep and circadian rhythms, both conspicuous targets of melatonin action. Melatonin is selectively taken up by mitochondria, a function not shared by other antioxidants. A limited number of clinical studies indicate that melatonin can improve sleep and circadian rhythm disruption in PD and AD patients. More recently, attention has been focused on the development of potent melatonin analogs with prolonged effects which were employed in clinical trials in sleep-disturbed or depressed patients in doses considerably higher than those employed for melatonin. In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin in the range of 50-100mg/day are needed to assess its therapeutic validity in neurodegenerative disorders.  https://pubmed.ncbi.nlm.nih.gov/22391273/

The pituitary releases hormones throughout the endocrine system to ensure physiological functions in our body; the pineal gland is mostly responsible for producing melatonin.

From PubMed  

ABSTRACT

The present study was carried out to investigate if ethanol alters the aromatization of androgens and concentrations of hepatic estrogen and androgen receptors. Hepatic aromatization of androgen to estrogen was significantly increased by ethanol administration. There was a significant increase in serum estrogen level but a decreased circulating testosterone level in alcohol-fed rats. Furthermore, the concentration of estrogen receptors in liver cytosol was significantly higher in alcohol-fed rats (37 +/- 5.3 fmol/mg protein), as compared to the intact control value (21 +/- 4.8 fmol/mg protein). However, hepatic androgen receptor levels were much lower (4.4 +/- 0.5) in alcohol-fed rats than those (10.2 +/- 1.4 fmol/mg protein) in control animals. Similarly, castration increased hepatic aromatization of androgens and concentrations of serum estrogen and hepatic estrogen receptors, but it decreased the contents of circulating androgen and hepatic androgen receptors. These findings indicate that alcohol administration is considered a chemical form of castration, altering the hepatic steroid metabolism and sex hormone receptor contents and contributing to the pathogenesis of feminization. A combination of alcohol-feeding and castration has no synergistic effect on the hepatic steroid receptors and aromatization, but this combination does have a more profound effect in lowering the concentration of circulating androgen.

Here are some foods that raise, or increase, your androgen receptors.  First, knock off the alcohol except for the occasional celebration of personal milestones.  Don't get me wrong.  I love red wine. Would drink it regularly if didn't have all the nasty side effects on the brain and liver.  Those side effects can make a person irritable and grumpy the next day for which you'll need plenty of coffee the next morning to revive yourself.  But alcohol and coffee both deplete your vitamin B stores.  In fact, these beverages are referred to as B blockers because they block the absorption of vitamin B into your tissues.  Because alcohol does have nasty effects on hormones even tissues, I abstained long ago, decades now.  I was always considered a lightweight when friends, relatives, and acquaintances had no problem putting away excessive amounts.  

Coffee does have benefits but too much can drain the brain of B vitamins and deplete the pituitary gland [A MAJOR PLAYER IN YOUR ENDOCRINE SYSTEM, sometimes called "the master gland"] hormones. 

Which hormones does the pituitary gland make?

The anterior lobe of your pituitary gland makes and releases the following hormones:

Adrenocorticotropic hormone (ACTH or corticotrophin): ACTH plays a role in how your body responds to stress. It stimulates your adrenal glands to produce cortisol (the “stress hormone”), which has many functions, including regulating metabolism, maintaining blood pressure, regulating blood glucose (blood sugar) levels and reducing inflammation, among others.

Follicle-stimulating hormone (FSH): FSH stimulates sperm production in people assigned male at birth. FSH stimulates the ovaries to produce estrogen and plays a role in egg development in people assigned female at birth. This is known as a gonadotrophic hormone.

Growth hormone (GH): In children, growth hormone stimulates growth. In other words, it helps children grow taller. In adults, growth hormone helps maintain healthy muscles and bones and impacts fat distribution. GH also impacts your metabolism (how your body turns the food you eat into energy).

Look at how these idiots describe biological functions.  Science is corrupted.  F**k these compliant bureaucrats.  "assigned"?  

Luteinizing hormone (LH): LH stimulates ovulation in people assigned female at birth and testosterone production in people assigned male at birth. LH is also known as a gonadotrophic hormone because of the role it plays in controlling the function of the ovaries and testes, known as the gonads.

Prolactin: Prolactin stimulates breast milk production (lactation) after giving birth. It can affect fertility and sexual functions in adults.

Thyroid-stimulating hormone (TSH): TSH stimulates your thyroid to produce thyroid hormones that manage your metabolism, energy levels, and your nervous system.

And a few more. 

But we all want a simplified life. In that case, ignore everything I've said or printed here, and go on about your business.  But if you want to maintain a high level of productivity long into your years, then be vigilant on bodily processes that deliver on productivity.   To keep your pituitary gland functioning at peak levels as you continue drinking coffee, then it would help, help a lot, to be consuming boron.  

The difference between the Pituitary Gland and the Pineal Gland is that the pituitary releases hormones throughout the endocrine system to ensure physiological functions in our body, whereas the pineal gland is mostly responsible for producing melatonin.  People take melatonin supplements to keep the pineal gland producing melatonin.  Boron helps to keep that organ regulated.  Pineal gland is not just for melatonin.  It's also responsible for critical thinking.  For the Pituitary gland, eat red meat, get sunlight at peak hours, 11-2, get Omega-3s through fish oil, and supplement with vitamin D. 

MELATONIN, THE ANTI-CANCER NUTRIENT

Can get pure Melatonin powder online at PureBulk or Bulk Supplements. High dose/1000mg also works fantastically for Covid (& more)! More on Melatonin for Cancer: https://t.co/TEBLSciuxy pic.twitter.com/LEcDc7ZHtO

— Natural Immunity FTW (@NaturallyFTW) December 12, 2022

The presentation was given by Dr. Frank Shallenberger.  

PureBulk is the site for buying in bulk.  BTW, if you need to phone PureBulk just know that their hours are 7am to 3pm, PST.  They close early.  

 

He explains that people don't die from cancer; they die when the cancer metastasizes.  

He says that with prostate cancer melatonin is a slam dunk. Now he uses additional compounds but melatonin is the main one and he gives it in massive amounts. I just didn't hear a dose amount.  He does say that Professor Russel Reiter in studying mice, gave mice, WHO WERE BRED TO GET BREAST CANCER, large amounts of melatonin and they DID NOT GET BREAST CANCER.  So there's that.  But how much, how much?  Reiter has said previously that he takes upwards of 140mgs of Melatonin/day.  I'd say that if someone has cancer that you'd want to go a little higher.

7 anti-cancer mechanisms of melatonin:

1.  Direct Anti-neoplastic effect.

2.  Decreases cell proliferation at low doses.

3.  Direct cytotoxic effect occurs with higher doses.

4.  Stimulation of cell differentiation.

5.  Induction of apoptosis.

6. Anti-angiogenic.  

7.  A synergistic effect has been found in several types of cancer when it is administered in combination with chemotherapy.  Shocked that he would use chemotherapy.  

SARS-CoV-2 can upregulate NLRP3 inflammasomes in the brain to induce neurodegenerative disorders, including Parkinson's disease. Melatonin targets NLRP3 inflammasomes. Now you know why MEL is effective against brain fog and memory loss after C-19 infections

SARS-CoV-2 can upregulate NLRP3 inflammasomes in the brain to induce neurodegenerative disorders including Parkinson's disease https://t.co/BxIFXMAPuQ Melatonin targets NLRP3 inflammasomes. Now you know why MEL is effective against brain fog and memory loss after C-19 infections. pic.twitter.com/mFst6FHpN9

— Doris Loh (@DorissLoh) November 10, 2022

High dose melatonin is best for anti-oxidant powers and less for sleep inducement.  But if you're interested, you should read everything about amazing melatonin by Doris Loh.   

"Ultraviolet C Band of light had germicidal properties due to it’s ability to break apart the DNA of organic matter"

MEL continues to impress. New peer-reviewed study reports the formation of potent antioxidant metabolite N1‐acetyl‐5‐methoxykynuramine (AMFK) upon exposure to UVC irradiation. This means: cytotoxic UVC will create more antioxidant protection via AMFK if MEL is present #MedTwitter pic.twitter.com/cY46zGMTyQ

— Doris Loh (@DorissLoh) October 31, 2022

UVC is a particular wavelength of light.  

All three bands have germicidal properties that make them beneficial for multiple applications in facility management, including:

Coil Irradiation in HVAC systems to boost energy efficiency and reduce maintenance.

Air Disinfection through the use of Upper Air Germicidal Irradiation units, which is very effective at controlling the spread of influenza virus, the common cold, and most every other airborne pathogen.

Surface Sterilization is a newer application and there are a variety of devices sold that claim to do this.  Although the technology is sound the efficacy of how the different systems deliver the UV-C light to the surfaces to be sterilized/decontaminated is questionable.

It was discovered way back in the 1890’s that the Ultraviolet C Band of light had germicidal properties due to it’s ability to break apart the DNA of organic matter.

You're no yellow-bellied rat . . . but as a precaution, take Melatonin . . .

Hypoperfusion is a term that describes "a reduced amount of blood flow". When ischemia develops due to low blood flow, we may describe this as "hypoperfusion". Causes for hypoperfusion include low blood pressure, heart failure or loss of blood volume.

Melatonin attenuates cerebral hypoperfusion-induced hippocampal damage and memory deficits in rats by suppressing TRPM7 channels  https://t.co/AjvXzldObG pic.twitter.com/YorWqkuyLj

— DCGreenZone1 🐭 (@DCGreenZone) October 28, 2022

Melatonin has shown significant benefits in reducing cardiac pathology, and preventing the death of cardiac muscle in response to ischemia-reperfusion . . .

I wonder if the CDC should tell parents of young children anything, or if they should just keep whistling past the graveyard. https://t.co/dWsOyOOAHN pic.twitter.com/7lLjIbcb3r

— DCGreenZone1 (@DCGreenZone) October 5, 2022

Melatonin has shown significant benefits in reducing cardiac pathology, and preventing the death of cardiac muscle in response to ischemia-reperfusion in rodent species.  Moreover, melatonin may also prevent the hypertrophy of the heart muscle  under some circumstances, which in turn would lessen the development of heart failure.

MELATONIN: For neuro-protection, not just sleep inducement, a lot melatonin is required: 50-100mg.

https://t.co/T6h5DJ9EeB
This article reviews the protective role of melatonin with mechanistic insights against mitochondrial diseases and sugg new avenues 4 safe and effective tx modalities against these devastating neurodegenerative diseases. Future insights are also discussed.

— DCGreenZone1 (@DCGreenZone) October 4, 2022

Below are the sections of each abstract that I thought were interesting and helpful. 

ABSTRACT #1

Melatonin is selectively taken up by mitochondrial membranes, a function not shared by other anti-oxidants, and thus has emerged as a major potential therapeutic tool for treating neurodegenerative disorders. Multiple in vitro and in vivo experiments have shown the protective role of melatonin for preventing oxidative stress-induced mitochondrial dysfunction seen in experimental models of PD, AD, and HD.  https://pubmed.ncbi.nlm.nih.gov/26087000/

For neuro-protection, not just sleep inducement, a lot melatonin is required: 50-100mg.    

ABSTRACT #2

Both in vitro and in vivo, melatonin was effective to prevent oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of AD, PD and HD. These effects are seen at doses 2-3 orders of magnitude higher than those required to affect sleep and circadian rhythms, both conspicuous targets of melatonin action. Melatonin is selectively taken up by mitochondria, a function not shared by other antioxidants. A limited number of clinical studies indicate that melatonin can improve sleep and circadian rhythm disruption in PD and AD patients. More recently, attention has been focused on the development of potent melatonin analogs with prolonged effects which were employed in clinical trials in sleep-disturbed or depressed patients in doses considerably higher than those employed for melatonin. In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin in the range of 50-100mg/day are needed to assess its therapeutic validity in neurodegenerative disorders.  https://pubmed.ncbi.nlm.nih.gov/22391273/

ABSTRACT #3

Melatonin is a tryptophan-derived ancestral molecule evolved in bacteria.

Throughout the aging process melatonin levels tend to reduce and as a manifestation of this, many symptoms in organisms' homeostasis, such as deterioration in adjustment of cellular clocks, are commonly seen. In addition, due to deterioration in mitochondrial integrity and functions, immunity decreases, and lower levels of melatonin renders older individuals to be more susceptible to impaired redox modulation and age-related diseases.  https://pubmed.ncbi.nlm.nih.gov/35895186/

Well, well, well . . . . Nattokinase degrades the spike protein floating in the blood and attached to the cell

You don't get any closer to a cure for COVID or for the toxic spike protein than Nattokinase.  And I was recommending this to everyone by June 2021.  Few listened, so I shipped a couple of small bottles via Amazon anyway.  Never heard back, whether they liked it or not.  So that was a sunk cost; at least now they know about it.  So as you take Nattokinase to degrade and neutralize the spike protein, be sure to take lots of melatonin to reverse some of the aging effects of the vaccine.

A suggestion that nattokinase which can be found in Japanese natto food can destroy the spike protein found on the surface of cells in a laboratory setting.
Source: Merogenomics. https://t.co/tIUgiRiQeh pic.twitter.com/CmHFhK3JxW

— Wittgenstein (@backtolife_2023) September 29, 2022

Anti-Aging Melatonin to the Rescue

Just published peer-review study found infection by SARS-CoV-2 regardless of disease severity to induce compromised lung physiology equivalent to 15 years of aging. https://t.co/BwPRNc5hta What is decreased in aging? Melatonin. https://t.co/5z8jAyQvCd Can MEL prevent C19 aging?

— Doris Loh (@DorissLoh) September 29, 2022

Be sure to get a second opinion on the anti-aging benefits of melatonin.  Dr. Russel Reiter says, 

I have a supply of melatonin with me at all times.  If I have a stroke or heart attack, I'll immediately load up on melatonin.  Based on what I know, I will take all the melatonin I can, as fast as I can.

MELATONIN: anti-Covid, anti-inflammatory, radioprotective, anti-cancer, safe supplement when taken at high doses (100-2000mg).

Melatonin significantly decreased the virus levels in blood and brain . . . 

Why I took 500mg Melatonin: My kiddo tested positive for Covid, after being exposed at daycare. Melatonin prevents viral brain entry (but only when one takes a high dose), prevents people from catching Covid, & helps w/Covid. So just in case, since I've been exposed. 🙂 pic.twitter.com/J8SdHzkHzq

— Natural Immunity FTW (@NaturallyFTW) August 26, 2022

Dr. Russell Reiter on Melatonin

  

Thanks to Chris @ Chris Beat Cancer.  

Show Notes
*  How Dr. Reiter got into melatonin research [1:23]
*  What melatonin does in the body [3:28]
*  How blue light inhibits melatonin production [7:05]
*  How melatonin is passed to the fetus and newborn [12:00]
*  The anticancer benefits of melatonin [15:25]
*  How pharmaceutical drugs suppress melatonin production [18:40]
*  When should melatonin be taken during the day? [22:47]
*  Does taking melatonin affect natural production? [24:36]

Blind people have lower rates of cancer due to the higher circulating melatonin in their blood.  [27:22]
*  Older people need more melatonin [29:20]
*  How melatonin can reduce the impact of Covid-19 [31:15]
*  The impact of alcohol and caffeine on melatonin production [34:45]
*  Melatonin acts as an antiviral [37:24]
*  How sunlight helps with the production of melatonin [44:35]
*  Melatonin can reduce the likelihood of metastasis [50:45]

MELATONIN'S UNEXPECTED BENEFITS: slows aging, Prevents . . . Parkinson's and Alzheimer's, protects against ionizing radiation, macular degeneration, treats cancer . . .

This was interesting.  

It's a review by Dr. Gary Gonzalez of Dr. Russel [one L] Breiter's book on melatonin.  Most of us, including myself, think of melatonin as a sleep aid or more recently as a valuable antioxidant.  Reiter explains just how valuable it is for longevity and radical health.  

The first longevity product that I'd ever heard or read about was Resveratrol and IP6.  IP6 was a longevity compound because it managed the EXCESS iron floating around in our blood, out of the tissue, as what is called "Unbound iron."  The excess iron produces an inflammatory protein that, if left untreated, leads to chronic diseases like arthritis, 

FEMALE LONGEVITY

The end result is even more compelling. For example, Reiter explains that five separate studies have shown that older women produce more melatonin than older men-suggesting a possible explanation for the long-observed female longevity factor." He details findings showing a marked correlation between brain functioning in older age and melatonin levels.

Shielding DNA From Free Radicals

Reiter explains melatonin's effects on the immune system of aging animals and determines whether or not these actions also apply to humans. Most importantly, he shows how melatonin fits in with the free radical theory of aging.

He explains that melatonin is found in the greatest abundance in the nucleus of the cell, where it shields the DNA molecule itself from free radical damage better than any other known substance. Reiter describes his own studies in which melatonin has protected DNA from free radicals generated by radiation, carcinogens, bacterial toxins, and most important the process of using oxygen for fuel.

UNEXPECTED BENEFITS

Even if you have no sleeping issues, anyone over 40 should be taking melatonin.  19 Research papers reveal that melatonin promotes all of these unexpected effects [in no particular order, though numbered:

1.  Protects against viral and bacterial infections.

2.  Prevents cardiovascular disease and high blood pressure. 

3.  Reduces oxidant stress and inflammation and slows aging. 

4.  Prevents neurodegenerative diseases such as Parkinson’s and Alzheimer’s. 

5.  Improves menopause therapy. 

6.  Protects against ionizing radiation. 

7.  Prevents macular degeneration. 

8.  Prevents and treats cancer.

Okay, so with all of these benefits, the only thing to consider is how much does, or should, one take?  First, I would say do a trial run.  By that I mean start with smaller amounts, say, 3mgs, and see how you feel upon waking, whether or not you can tolerate melatonin to begin with, or tolerate that amount.  When I first tried melatonin, I woke up and could barely raise my arms, and my legs felt like bricks.  But when I was working a physically demanding job for a few years, I noticed that the only way to turn the pain off was excess melatonin, and excess was 5 to 10mgs back in 2018.  Since then, I've been taking upwards of 12 to 20mgs, but not every night.  For, at least in my case, melatonin doesn't deliver a deep sleep for me.  But I still take it for the other unexpected benefits listed above.  

So how much should you take?  The answer is contingent on several factors.  One, if you've got a serious disease, like cancer, then you want to take more.  Bill Sardi recommends 15-30mgs nightly for cancer treatment in conjunction with several other compounds.  

MELATONIN: NOT JUST A SLEEP AID BUT ". . . THE MOST POWERFUL ANTIOXIDANT TOOL IN THE WORLD"?

I love her claim that melatonin is a more powerful antioxidant than glutathione, which is considered the master antioxidant.  Imagine the healing that could take place if you took both glutathione AND melatonin.  Be sure to open up that thread by clicking on Natural Immunity's Twitter link.  Melatonin benefits go beyond anticancer.  It keeps our skin healthy and youthful [through] two major mechanisms. It has antioxidant effects that neutralize oxidative damage from the sun, and by stimulating growth receptors in the skin.  NaturalImmunity goes on to say that 

Melatonin may have a profound effect on stroke & heart attack! Take w/in 1st 2 hrs. Based on studies, if were me, I'd take ~2000mg, since oral bioavail is low (& that amt has been shown 2b safe). Then 100mg+ every hour or so for 24/48 hrs. (Not medical advice)!

MELATONIN - more potent than glutathione #NotForSleep pic.twitter.com/cKLiNhzUdr

— Natural Immunity FTW (@NaturallyFTW) May 21, 2022

Christopher Wark of Chris Beat Cancer interviews Dr. Russell J. Reiter.  A powerful interview here on how necessary darkness is for our circadian rhythms and our health.  Modern life with night lighting is fairly new in our evolution, disruptive of natural processes, and disease generating.  So embrace the darkness.  Be sure to check out the show notes in the link, "Chris Beats Cancer" above.  Here is a sampling from those notes:

Melatonin acts as an antiviral [37:24]
-How sunlight helps with the production of melatonin [44:35]
-Melatonin can reduce the likelihood of metastasis [50:45]

Clearly, the antioxidant action of melatonin is quite powerful as an anti-cancer compound. Bill Sardi included it in his nutritional compound regimen for cancer, in fact, 15-30mg of melatonin per night.  So there is credible consensus on the anti-cancer benefits of melatonin.

I have to say that any time I hear or read about the anti-aging benefits of melatonin, or any product, my ears perk up.  Antiaging means that you only slow down the aging process.  In some cases, it may be possible to reverse aging processes, like alopecia, or hair loss, this can be reversed with Rutin, Pumpkin Seed Oils, and B5.  This video, which I didn't have the time to watch all the way through, highlights that 1) Melatonin is an ancient molecule.  That's interesting, but what is the relevance of that?  What benefits are derived from its ancient characteristics?  2) It's found in bacteria and every organism between bacteria and mammalians.  Its structure has never changed throughout its evolution, what that means is that the structure of melatonin in bacteria is identical to the structure of melatonin in humans.  Whoa.  Now that is something, but what does that tell us?  That melatonin means life itself?  3) it is not toxic at any dose. 4) it exists in every species that is currently living or that has ever existed.  I mean what is not to like?  For optimal cellular physiology.  Melatonin exhibits in the blood circadian rhythm.  [7:38] "Melatonin is a very strong anti-cancer agent."  It influences the immune system, metabolism, gastro-intestinal function.   

Check out Melatonin by Russell J. Reiter; Jo Robinson https://t.co/dJ1CO1lM No #eBay via @eBay

— Mike Walgenbach (@mwalgen44) May 21, 2022

Show Notes from Chris Beat Cancer

-How Dr. Reiter got into melatonin research [1:23]
-What melatonin does in the body [3:28]
-How blue light inhibits melatonin production [7:05]
-How melatonin is passed to the fetus and newborn [12:00]
-The anticancer benefits of melatonin [15:25]
-How pharmaceutical drugs suppress melatonin production [18:40]
-When should melatonin be taken during the day? [22:47]
-Does taking melatonin affect natural production? [24:36]
-Older people need more melatonin [29:20]
-How melatonin can reduce the impact of Covid-19 [31:15]
-The impact of alcohol and caffeine on melatonin production [34:45]
-Melatonin acts as an antiviral [37:24]
-How sunlight helps with the production of melatonin [44:35]
-Melatonin can reduce the likelihood of metastasis [50:45]