MARC LANDERS: THCV & THC showed strong potential to block cholinesterase enzymes. Cholinesterase enzymes break down acetylcholine, a chemical in the brain that helps nerve cells communicate and supports memory and thinking.

Could Cannabis Hold the Key to Fighting Alzheimer’s?

Two cannabis compounds, tetrahydrocannabivarin (THCV) and Δ-9-tetrahydrocannabinol (THC), showed strong potential to block cholinesterase enzymes.

Cholinesterase enzymes break down acetylcholine, a chemical in the brain that… pic.twitter.com/CxVeJTC6sa

— Marc Landers (@marclanders) June 18, 2025

Could Cannabis Hold the Key to Fighting Alzheimer’s? Two cannabis compounds, tetrahydrocannabivarin (THCV) and Δ-9-tetrahydrocannabinol (THC), showed strong potential to block cholinesterase enzymes. Cholinesterase enzymes break down acetylcholine, a chemical in the brain that helps nerve cells communicate and supports memory and thinking. These compounds stuck to the enzymes better than two existing Alzheimer’s drugs, Rivastigmine and Galantamine.

"Exploring Cannabis sativa L for Anti-Alzheimer Potential: An Extensive Computational Study including Molecular Docking, Molecular Dynamics, and ADMET Assessments," Nour, et al, Med Chem, 2025;21(5); 367-384.  

ADMET is a manufacturer testing system.

THCV is a cannabinoid known for its appetite-suppressing effects.  It is being studied for its possible benefits in managing obesity and Type II diabetes, and now fighting Alzheimer's.