"The highest levels of COQ10 are in the organs of our body that need the most energy--so heart, liver, kidneys."

The best food source of COQ10 that you can get is heart, so beef heart, sheep heart, goat heart, chicken hearts.  Keep in mind that people have been eating [animal] hearts for millions of years.  Ken D. Berry, MD

One of the most honest medical professionals you will ever have the chance to listen to. https://t.co/NvAOFJ5bcI

— DCGreenZone1 (@DCGreenZone) October 24, 2022

A long list of medications that will tank your COQ10 levels. 

A coenzyme that hundreds of chemical interactions that your body needs to function optimally. 

The chemical name for Ubiquinol is ubiquinone, which rhymes with ubiquitous.  And the reason they named it that is because every animal on the planet, and most bacteria, have to have ubiquinone, or COQ10, in order to function optimally.  Something needed like this across all animal kingdoms, that's a hint that it's very, very important.  

Most of the COQ10 in your body is stored and used by your mitochondria.  The mitochondria make most of the energy molecules, the ATP and NADH that your body uses for energy.  So right off the bat, that if your COQ10 levels are low, you're just not going to have the energy that you need to function optimally.

Common side effect of low COQ10 levels is fatigue. 

The highest levels of COQ10 are in the organs of our body that need the most energy--so heart, liver, kidneys.  These have a much higher concentration of COQ10.  But what if you're taking a medication, a prescription or over-the-counter, that's tanking your COQ10 levels and you don't even know it.  And these organs are not going to be getting the COQ10 that they need for optimal functions.  

Statins drastically reduce your body's stores of COQ10.

Acid Blockers, or even over-the-counter antacids, also reduce your body's stores of COQ10.  So drugs like Nexium, Prevacid, Zantac, Prilosec, all of these meds are going to lower your COQ10.  Antacids like Rolaids, Tums, Mylanta, they're going to lower your body stores of COQ10.  

Many antibiotics Keflex, Cipro, Levaquin, Bactrim, they're going to lower your stores of COQ10 that your mitochondria take up for energy.  

Anti-depressants, like Elavil or Pamelor lower your COQ10 levels.

Blood-thinners Coumadin and Warfarin lower your COQ10 levels.  

A long list in the show notes.  Be sure to check out that list to see which meds you're taking.

FOODS RICH IN COQ10

Any cut of meat from any land animal or any fish that swims in the water is going to be a decent source of CO Enzyme Q10.  The best food source of COQ10 that you can get is heart, so beef heart, sheep heart, goat heart, chicken hearts.  Keep in mind that people have been eating [animal] hearts for millions of years.

DR. BERRY'S RECOMMENDATION

Don't take a chalky tablet.  Take an olive oil filled gel cap that has at least 100 milligrams of COQ10 . . . .  Dr. Berry says to take 100mg for each of the medications that you're taking.  So if you're taking 3 of the meds listed in his show notes, that means you take 300mgs of COQ10.  He cautions that if you're not taking any of these medications, and you take 1,000 mgs of COQ10 per day, it's not going to be harmful but it could cause some stomach upset.  That'd be about the worst of it, he explains. 

"High dose thiamine improves symptoms of fibromyalgia, Freidreich's ataxia, Parkinson's disease, and in biotinthiamin responsive basal ganglia disease, suggesting the expanding role of epigenetics."

The absence of blood thiamine def and the efficacy of high-dose thiamine in our pts suggest that fatigue is the manifestation of a thiamine deficiency, likely due to a dysfunction of the active transport of thiamine inside the cells or due to structural enzymatic abnormalities

— DCGreenZone1 (@DCGreenZone) October 16, 2022

Make sure that you get the fat-soluble forms of thiamine, like Allithiamine, Benfotiamine, or Lipothiamine.  Remember that Thiamine is a B vitamin, vitamins that we take for granted because there are so many forms of them as well as so many dietary sources of B vitamins.  But buyer beware.  We're more at risk of losing B vitamins today than we are at gaining them.  One reason for this are the B-blockers, foods and drinks that block the absorption of B vitamins.  And if we consume these B-blockers on a daily or regular basis, we also risk the developing a condition where we're no longer able to absorb B vitamins adequately.  So it's a serious trade-off. 

Bonnie Fields @ needs.com provides us with sobering reminders,

thiamine plays a pivotal role in the metabolism of glucose as well. The ingestion of an excessive amount of refined simple carbohydrates, such as sodas, fruit juices, sugary snacks, etc. automatically increases our need for thiamine.

A number of naturally occurring compounds produce anti-thiamine activity and anti-thiamine factors, like thiaminase enzymes. Thiaminase enzymes are found in tea, brussels sprouts, red cabbage, mussels, oysters, and urinary thiamine levels are reduced when a person consumes coffee. 

Fields makes an important observation, 

Thiamine deficiency has been implicated in restrictive weight loss surgery, in the use of parenteral nutrition, optic neuropathy, anorexia nervosa, and congestive heart failure." Dr. Lonsdale also points out that "the initial symptoms of thiamine deficiency beriberi are those of dysautonomia, a broad term that describes any disease or malfunction of the autonomic nervous system." He further cites references showing that "High dose thiamine improves symptoms of fibromyalgia, Freidreich's ataxia, Parkinson's disease, and in biotinthiamin responsive basal ganglia disease, suggesting the expanding role of epigenetics." 

Basal ganglia disease?  Why that's exactly what the spike protein is causing tens of thousands if not hundreds of thousands of vaccinated people.  Does this mean that fat-soluble thiamine is a remedy for basal ganglia disease?  I would certainly try this compound if I had the jab or if I had spike proteins in my system.  

In his book "The Natural Way to a Trouble-Free Pregnancy: The Toxemia/Thiamine Connection," Dr. John B. Irwin explains that thiamine supplementation, preconceptually and throughout pregnancy, is as important as folic acid supplementation, but is often overlooked. 

And to press the point to just the right end, 

fat-soluble thiamine or thiamine tetrahydrofurfuryl disulfide (TTFD), sometimes referred to as allithiamines, easily diffuses through plasma membranes, which strongly increases thiamine activity throughout our blood stream, red blood cells, cerebrospinal fluid, and urine. 

Articles referenced in the Fields' article.  

"A Review of the Biochemistry, Metabolism, and Clinical Benefits of Thiamine and its Derivatives," Dr. Derrick Lonsdale, 2006, and "Thiamine and Magnesium Deficiencies: Keys to Disease," Derrick Lonsdale, 2014.  

Selenium for Hypothyroidism and to Detox Mercury

https://t.co/n2kWY7r39E

— DCGreenZone1 (@DCGreenZone) October 11, 2022

Selenium for Mercury detoxification.  It's most concentrated in the thyroid gland.  It will decrease certain antibodies.  At the 12:15 mark, Sardi explains that the organic forms of Selenium in the form of Selenomethionine, stops cancer over Selenite found in cheap multivitamins.  

Sardi explains that "eyes and the skin age faster than the rest of the body because of exposure to sunlight.  Arteries stiffen and plaque builds up in the brain, there's a relationship between these twos.  When arteries are stiff, you're going to have high-blood pressure."

Liposomal encapsulated vitamins increase vitamin absorption into the cells by 1,000%

This is how the evil that is Pharma will be defeated. pic.twitter.com/MYIRWV00Cp

— DCGreenZone1 (@DCGreenZone) October 10, 2022

Melatonin is a well-recognized endogenous hormone involved in the control of brain functions and maintenance of blood-brain barrier integrity.

All I can say is that if you're not taking melatonin, you're not doing the best you can at self-care.   

Anyone wondering what else it can protect us from? Hmmm?
Melatonin is a well-recognized endogenous hormone involved in the control of brain functions and maintenance of blood-brain barrier integrity.   https://t.co/JO7dANsSCs

— DCGreenZone1 (@DCGreenZone) October 5, 2022

Remember that in the low dosage is where Melatonin provides some decent sleep inducement.  For me, it keeps me asleep through the night and gives me some of the best dreams.  Meaning that they're always smooth and lead on from one event to the next without any perilous events that startle and wake me.  So I like that.  In higher doses, say, 40-100mg or more is where melatonin's neuroprotective activities kick in.  

Melatonin has shown significant benefits in reducing cardiac pathology, and preventing the death of cardiac muscle in response to ischemia-reperfusion . . .

I wonder if the CDC should tell parents of young children anything, or if they should just keep whistling past the graveyard. https://t.co/dWsOyOOAHN pic.twitter.com/7lLjIbcb3r

— DCGreenZone1 (@DCGreenZone) October 5, 2022

Melatonin has shown significant benefits in reducing cardiac pathology, and preventing the death of cardiac muscle in response to ischemia-reperfusion in rodent species.  Moreover, melatonin may also prevent the hypertrophy of the heart muscle  under some circumstances, which in turn would lessen the development of heart failure.

MELATONIN: For neuro-protection, not just sleep inducement, a lot melatonin is required: 50-100mg.

https://t.co/T6h5DJ9EeB
This article reviews the protective role of melatonin with mechanistic insights against mitochondrial diseases and sugg new avenues 4 safe and effective tx modalities against these devastating neurodegenerative diseases. Future insights are also discussed.

— DCGreenZone1 (@DCGreenZone) October 4, 2022

Below are the sections of each abstract that I thought were interesting and helpful. 

ABSTRACT #1

Melatonin is selectively taken up by mitochondrial membranes, a function not shared by other anti-oxidants, and thus has emerged as a major potential therapeutic tool for treating neurodegenerative disorders. Multiple in vitro and in vivo experiments have shown the protective role of melatonin for preventing oxidative stress-induced mitochondrial dysfunction seen in experimental models of PD, AD, and HD.  https://pubmed.ncbi.nlm.nih.gov/26087000/

For neuro-protection, not just sleep inducement, a lot melatonin is required: 50-100mg.    

ABSTRACT #2

Both in vitro and in vivo, melatonin was effective to prevent oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of AD, PD and HD. These effects are seen at doses 2-3 orders of magnitude higher than those required to affect sleep and circadian rhythms, both conspicuous targets of melatonin action. Melatonin is selectively taken up by mitochondria, a function not shared by other antioxidants. A limited number of clinical studies indicate that melatonin can improve sleep and circadian rhythm disruption in PD and AD patients. More recently, attention has been focused on the development of potent melatonin analogs with prolonged effects which were employed in clinical trials in sleep-disturbed or depressed patients in doses considerably higher than those employed for melatonin. In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin in the range of 50-100mg/day are needed to assess its therapeutic validity in neurodegenerative disorders.  https://pubmed.ncbi.nlm.nih.gov/22391273/

ABSTRACT #3

Melatonin is a tryptophan-derived ancestral molecule evolved in bacteria.

Throughout the aging process melatonin levels tend to reduce and as a manifestation of this, many symptoms in organisms' homeostasis, such as deterioration in adjustment of cellular clocks, are commonly seen. In addition, due to deterioration in mitochondrial integrity and functions, immunity decreases, and lower levels of melatonin renders older individuals to be more susceptible to impaired redox modulation and age-related diseases.  https://pubmed.ncbi.nlm.nih.gov/35895186/

NATTOKINASE DEGRADES AND REDUCES AMYLOID FIBRILS ASSOCIATED WITH ALZHEIMER'S

https://t.co/SEjyXZrWTR
NATTOKINASE FOR DEGRADING AND REDUCING AMYLOID FIBRILS ASSOICATED WITH ALZHEIMER'S DISEASE, PRION DISEASES AND OTHER AMYLOIDOSES

— DCGreenZone1 (@DCGreenZone) October 2, 2022

Fx of Nattokinase include directly degrading a fibrin activating pro-urokinase (precursor for urokinase that is an thrombolytic enzyme in the body) and increasing the amount of tissue plasminogen activator (t-PA) that produces a thrombolytic enzyme plasmin https://t.co/6PVniYErHF

— DCGreenZone1 (@DCGreenZone) October 3, 2022

"NMN supplementation was capable of restoring NAD+ levels by threefold"

When considering the potential benefits of NMN, you have to read the safety data, and there isn't much to date. However. Reading about what you may be considering to put in your body is a must. https://t.co/nr3u4Vfsvq

— DCGreenZone1 (@DCGreenZone) September 25, 2022

Some promising benefits from NMN.

Administration of NMN also can restore gene expression linked to circadian rhythm, inflammatory response and oxidative stress, and improve hepatic insulin sensitivity, partially by SIRT1 activation.  

See the table at the end of this sentence for a list of benefits from NMN: Table 1.  

NMN supplementation was capable of restoring NAD+ levels by threefold:

De Picciotto et al. [29] found that NMN supplementation was capable of restoring NAD+ levels (by threefold), vascular SIRT1 activity, maximum carotid artery endothelium‐dependent dilation, and nitric oxide‐mediated carotid artery endothelium‐dependent dilation in mice. Kawamura et al. [30] have reported that NMN retained in animals for longer period than nicotinamide. NMN resulted in a higher yield of NAD+ (80 nmol/g of liver tissue) in salvage biosynthesis pathway activating higher response of SIRT1 than nicotinamide. 

And the list goes on:

Mills et al. [10] found that devoid of any apparent deleterious effect or toxicity, 

NMN effectively suppressed aging-induced body weight gain 

ameliorated eye dysfunction in mice. 

maintained healthy plasma lipid profile, insulin sensitivity, physical activity, energy metabolism and other physiopathologies. 

NMN supplementation averted alterations in age-associated gene expression in main metabolic organs, while enhancing mito-nuclear protein imbalance and mitochondrial oxidative metabolism in skeletal muscles. 

NMN supplementation restored reduced contents of renal protective molecule, SIRT1 and its cofactor, NAD+. The heightened NAD+ and SIRT1 levels in kidneys of aged mice protected aged kidneys from both ischemia–reperfusion- and cisplatin-induced acute kidney injuries.

This brand came recommended from a friend on Twitter.

 

Adults Need 50 ng/ml Vitamin D Daily. That Translates to 5,300 IU

Remember, not a word about this from Fauci or Walensky. They have sealed their place in history. pic.twitter.com/zxbSmdL0lh

— DCGreenZone1 (@DCGreenZone) September 17, 2022

The goal then for a daily healthy immune system is 50 ng/ml.  For a translation, that means 5,300 IUs of vitamin D.

20 ng/ml . . . 1000 IU
30 ng/ml . . . 2200 IU
40 ng/ml . . . 3600 IU
50 ng/ml . . . 5300 IU
60 ng/ml . . . 7400 IU

70 ng/ml . . . 10100 IU 

Check this out:

Everyone needs at least 50 ng/mL 125nmol/L 25-hydroxyvitamin D for their immune system to function properly.  Without proper vitamin D3 supplementation, most people's 25-hydroxyvitamin D levels are 1/2 to 1/10th this - greatly raising the risk of severe symptoms from COVID-19, Kawasaki disease, Multisystem Inflammatory Syndrome and sepsis.

Here are the live links that appear in the above graphic. 

1.  Serum Vitamin D levels are associated with increased COVID-19 severity and mortality independent of visceral adiposity | medRxiv

That article explains that to fight any disease, you need a minimum of 50 ng/ml of vitamin D to have a fortified immune system to fight anything.  Most people don't think vitamins work.  They won't turn you into a Popeye, though some can, but they'll give you immunity so that you can stay productive.  

2.  Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: study of 1326 cases from the UK Biobank - PubMed (nih.gov)

3.  Sci-Hub | Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism is not a risk factor for hypertension in SLE nephritis. Clinical Rheumatology, 34(9), 1545–1549 | 10.1007/s10067-015-2954-6  I don't understand the relevance of this paper to the importance of vitamin D.

4.  Vitamin D status of children with paediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS) - PubMed (nih.gov).  The idea here is the same in the others above--that vitamin D deficiency outcomes are worse.  Don't know how to put it any plainer.  The last line in the abstract reads, ". . . public health measures to improve vitamin D status of the UK BAME population have been long overdue."  So, it looks like in the UK, they're trying to make vitamin D a prescription of public health policy. 

5.  Nutrition to reduce COVID-19 serious harm and death (aminotheory.com).  This paper argues for vitamin D to improve against COVID-19.  C19 and Ivermectin.  But how does one get IV without a prescription?  Is an airport in Mexico the only way?

It offers a good link here:  

For links to the most pertinent research on why vitamin D (and Ivermectin) are effective at reducing severity of COVID-19, as well as reducing transmission, please see this page on my other site.  https://vitamindstopscovid.info.  

6.  Everyone needs at least 50ng/ml 125nmol/L 25-hydroxyvitamin D for their immune system to function properly (vitamindstopscovid.info) 

7.  Nutrition Matters | Robin Whittle | Substack.  

PQQ deficiency reduces mitochondria content and mitochondrial-related gene expression.

I'm Pharma, and I'm going to capitalize on your illness by producing fake wellness. I'm going to replace Mg, Glycine, Cysteine, Omega 3s, PQQ, CoQ10 etc with a toxic substance. Stay tuned for our latest snake oil coming to a drug store near you. pic.twitter.com/OaB7CfTwyk

— DCGreenZone1 (@DCGreenZone) August 4, 2022

PQQ.  So what is it?  It's an antioxidant.  PQQ stands for pyrroloquinoline quinone and was first recognized as an enzyme cofactor in bacteria by Norwegian biochemist Jens Hauge in 1964.[iii] It wasn’t until 2003 that Japanese brain researcher Tadafumi Kato found that PQQ also occurs in rodents and other mammals, including humans.

As an enzyme cofactor, PQQ, is critical to the life of your brain cells.  And some would say it's even critical to life itself.  "Cofactors" are molecules that act as a helper for enzymes that need assistance to work properly.  

What gives me pause about all of these antioxidants is that each one claims to be the most powerful antioxidant.  Each one.  From Acai berry to olive oil to melatonin and now PQQ.  I'm not saying that they're not powerful each and every one of the, including vitamin E and vitamin C.  But jeez, we've got to find a way to cut through the claims.  Doris Loh does some excellent work on the incredible benefits of melatonin.  Her website is here, but I really like her Twitter feed.  

"Klenner stressed that dangerously ill patients should receive large doses of vitamin C when doctors need more time to make a diagnosis."

Polio is trending. https://t.co/uDJNqizJRv    pic.twitter.com/YhpWcEvwN3

— DCGreenZone1 (@DCGreenZone) July 21, 2022

from Dr. Ken Walker @ Orthomolecular, 

What can history tell doctors about meningitis?  In 1949, Dr. FrederickRobert Klenner was a family doctor in North Carolina when the great poliomyelitis epidemic struck North America.  Klenner had no training in treating polio and no laboratory facilities.  But he was placed in charge of 60 patients suffering from early polio.  At that time, there was no specific treatment to prevent paralysis. 

In 1948, Klenner had previously cured several patients of viral pneumonia using intravenous vitamin C.  So he decided to give his polio patients up to 30,000 milligrams of vitamin C intravenously for 14 days.  None of these patients developed paralysis.  (Ironically, in 1949, I developed polio in my final year at The Harvard Medical School and I did develop paralysis.  But none of my eminent professors were aware of the benefits of massive doses of intravenous vitamin C). 

Dr. Klenner presented his monumental research to the annual meeting of the American Medical Association in Atlantic City, New Jersey on June 10^th, 1949.  Klenner should have been awarded the Nobel Prize in Medicine.  But his discovery failed to make headlines around the world and is still collecting dust. 

Spurred on by this scientific finding, Klenner later reported that he had cured meningitis, encephalitis, measles, and other diseases by large doses of IV vitamin C.  Since his death, other researchers have verified his findings. 

Klenner stressed that dangerously ill patients should receive large doses of vitamin C when doctors need more time to make a diagnosis.  And that, unless our white blood cells, needed to fight infection, are saturated with vitamin C they are like soldiers without bullets.  I believe his sage advice could save lives today and might have saved the life of this child. 

 

So why vitamin C?

McDonagh Med explains,

The function of vitamin C is to activate an enzyme in the white blood cell, called myeloperoxidase. The enzyme main function is to produce hydrogen peroxide (which gives rise to the highly energetic and bactericidal and viradical hydroxy free radical), which makes the white cells Super Killers as far as bacteria and viruses are concerned. 

By the way, this high-dose vitamin C protocol not only worked for polio, measles, meningitis, and encephalitis, but it also worked for multiple sclerosis.

Here is a brief history/synopsis of polio.  It's pretty good because it unearths some of the erroneous assumptions that we've made, or that doctors have made, about polio.  

1. The polio story as you learned it is wrong. It’s one of the most often misunderstood sequence of events in the last two hundred years. I wanted to explain a few things about the disease to help people understand what actually happened. pic.twitter.com/xT7YjIb4kZ

— Forrest Maready (@forrestmaready) June 8, 2018

TREATING COVID-19: IT'S ZINC & SELENIUM FOR THE WIN!!!

Two and a half years into this and they don't know yet. They should have known within the first two months. Fire them all. https://t.co/44fNLEmnKX    pic.twitter.com/Jqd5tszthz

— DCGreenZone1 (@DCGreenZone) July 21, 2022

CellG8 makes real, actual Liposomes. Other companies just add Phosphadylcholine to the pill.

Stopped at VS, saw "Vthrive Liposomal Vit C on a table at the front. Buy one, get one 50% off. $14.99 for 60, $27.99 for 120. So.... getting the larger bottle, ÷×¥≤×=. $41.00 for 240. CellG8 makes real, actual Liposomes. Other companies just add Phosphadylcholine to the pill. pic.twitter.com/ZI5vbLbdYY

— DCGreenZone1 (@DCGreenZone) July 17, 2022

This sounded interesting.  If you're looking for a liposomal product made without Phosphadylcholine, then CellG8 makes such a product.  They do make a B12 product, so that could be something you might be interested in.  I've never shopped at the Vitamin Shoppe, but I think I will try it.  

TALK ABOUT Top Quality Liposomal Quercetin Products

It's called Quercetin Lipo Micelle on Amazon. I told you Liposomes will completely change the wellness industry, this is what will remove the $$ from Pharma and remove their deathgrip from your Govt. and society itself. pic.twitter.com/xnLBpCcLmI

— DCGreenZone1 (@DCGreenZone) July 6, 2022

1.  Rachelle Osmond, 5/5 Stars.  The only quercetin that actually works. Reviewed in Canada on December 7, 2021  Size: 60 Count

After trying a few different brands for allergies and seeing no results, we switched to this.  There is a noticeable difference!  Apparently, quercetin is not very bio available so you do have to be selective about which supplement you take, or you’re throwing your money out the window.  Some science also suggests that this may be effective in treating “you know what.” 

2.  Laura G. 5/5 Stars.  Helps with pain, reviewed in Canada.  November 26, 2021.  I bought this as an immune booster but quickly found that it helped with the pain I’ve been having in my hip; as in, no more pain!  My husband also noticed it has helped with leg pain/cramps.

3.  Catherine 2/5 stars.  Caution needed.  Reviewed in Canada on December 21, 2020.  Zero noticeable difference except a nice case of hives down my arms a couple of hours after taking; as with any supplement, use caution and even speak to your doctor before taking; make sure you know what the ingredients are and if you’re allergic. 

4.  Francis Z.  5/5 stars.  Great value.  Reviewed in Canada on February 10, 2022.  My wife has psoriasis and she is quite happy taking it. 

5.  Amazon Customer: 2 out of 5 stars.  Bad taste.  Reviewed in Canada on February 18, 2022. 

We had to cut them open to give our little guy because he can’t swallow the pills but it’s so disgusting, had to return.  Probably better if you’re just taking the whole capsule. 

Rashad recommends this liposomal Quercetin:

Yes. This is what I use:
Natural Factors, Quercetin LipoMicel Matrix 250 mg, 30 Softgels https://t.co/1RnayWDRXe

— Rashad (@compsciman) July 7, 2022

A warning about NAC for those who have emphysema or COPD

A warning about NAC for those who have emphysema or COPD. https://t.co/dyEiCxmWVJ

— DCGreenZone1 (@DCGreenZone) July 6, 2022

Lung adenocarcinoma development in NAC-treated mice.

Lung tissue histology in aged NAC-treated animals revealed the formation of tumors exhibiting lung adenocarcinoma characteristics in 50% of JunD–/– mice and in 10% of controls (Figure 4, A and B). The appearance of the tumors was typical of adenocarcinoma with conspicuous papillary structures associated with a collagen network that stained with Sirius Red, as reported in previous studies (Figure 4, C and D, and ref. 15). Adenocarcinoma tissue sections were also characterized by high counts of Ki67-positive cells compared with nonadenocarcinoma tissue (Figure 4E). In contrast, p21 and p16 staining activities were not detected in adenocarcinoma tissue (Figure 4F). No such tumors were detected in vehicle-treated JunD–/– or control mice, even when studied until 24 months of age. No animals in any group had tumors detected in the liver, spleen, or kidneys. Moreover, in situ studies detected no associated lesions in mice with lung cancer. Inflammatory infiltrates were detected in the lungs of most of the aged mice (Figure 4G) and were more marked in the aged JunD–/– mice than in their controls but were not affected by NAC treatment (Figure 4G). These changes were not related to alterations in lung levels of mucin (16), which did not differ between aged and young mice and which was not affected by JunD  inactivation (Supplemental Figure 2).

Definitely interesting and well-worth a conscious pause in the use of NAC.  Other antioxidants are available that seemingly have no increased risk of tumor growth.  

Cell senescence is known to inhibit cell transformation and tumor initiation. We consequently hypothesized that NAC treatment promoted tumor initiation by inducing escape from cell senescence (17, 18). Interestingly, p16- and p21-stained cells, although sparsely distributed in lungs from NAC-treated mice, were not seen within tumors (Figure 4F). In contrast, Ki67-stained cells were seen only within tumors (Figure 4B). JunD–/–-derived mouse embryonic fibroblasts (MEFs) display p53-dependent premature senescence (19), and NAC treatment decreases p53 levels in the context of lung tumor progression in mice (8). Accordingly, we found decreased lung p53 protein and p16 mRNA levels in NAC-treated aged mice (Supplemental Figures 3 and 4), supporting the concept that NAC limits the expression of key senescence effectors and tumor suppressor genes

 

BERBERINE CAN TREAT SENILE DEMENTIA BY REGULATING NEUROTRANSMITTER

https://t.co/fLL5bKYuHV
Recent studies73 have evidenced that berberine can treat senile dementia by regulating neurotransmitter, antioxidative stress, and neuroinflammation and affecting metabolism and other multitarget pathways.

— DCGreenZone1 (@DCGreenZone) March 27, 2022