SAMA HOOLE: Lean meat has a protein ceiling - you can only metabolise so much before gluconeogenesis becomes toxic. Fat has no such ceiling. You can derive 80% of calories from fat indefinitely. This is why fat, not protein, was the evolutionary driver.

Lean meat has a protein ceiling - you can only metabolise so much before gluconeogenesis becomes toxic.

Fat has no such ceiling.

You can derive 80% of calories from fat indefinitely.

This is why fat, not protein, was the evolutionary driver.

Protein came along for the ride.

— Sama Hoole (@SamaHoole) October 10, 2025