SAMA HOOLE: Lean meat has a protein ceiling - you can only metabolise so much before gluconeogenesis becomes toxic. Fat has no such ceiling. You can derive 80% of calories from fat indefinitely. This is why fat, not protein, was the evolutionary driver.

Lean meat has a protein ceiling - you can only metabolise so much before gluconeogenesis becomes toxic.

Fat has no such ceiling.

You can derive 80% of calories from fat indefinitely.

This is why fat, not protein, was the evolutionary driver.

Protein came along for the ride.

— Sama Hoole (@SamaHoole) October 10, 2025

MICHAEL EADES, MD: subjects with mild renal failure on a ketogenic diet with plenty of protein. Not only did the renal failure NOT worsen, it improved

One of the vampire myths that refuse to die is that dietary protein damages the kidneys. This study put subjects with mild renal failure on a ketogenic diet with plenty of protein. Not only did the renal failure NOT worsen, it improved. https://t.co/SHr4Zut3HE pic.twitter.com/QxmCOpu2eS

— Michael Eades, M.D.🏹 (@DrEades) March 10, 2020

Ah, how times change. For years people have been saying--with no evidence--that dietary protein harms the kidneys. Now comes a paper advocating the ketogenic diet as a treatment for chronic kidney disease. https://t.co/oIXiyQYfO4 pic.twitter.com/5dHyI81HAZ

— Michael Eades, M.D.🏹 (@DrEades) June 5, 2022

Eating Eggs for 30 Days

Thank you to BodyNetwork.

02:25  Highest quality source of protein other than breast milk.  It has virtually every nutrient that you need.  Its amino acid profile is complete.  Its nutrients and amino acids are very bioavailable.  The waste product from eggs is so minimal because you're utilizing all this great protein.  

03:00  The protein you get from plant-based sources is actually pretty poor.

03:35.  Here you have this meat that we've been eating for thousands of years it's not just nutrient-dense but if you're consuming something that's grass-fed and grass-finished, you are getting a very high source of protein that can greatly help you not just with your muscles but repair the proteins overall in general.  Sometimes people think about proteins as just muscle, but you have all the enzymes in your body, the different metabolic pathways are all protein, a good portion of your skin is protein, a good portion of your bone is protein; your immune system is protein.  So when we're trying to replenish and repair proteins, we need sufficient proteins and bioavailable sources that our body can really use efficiently.  Eggs are at the top of the list. 

One egg will give you 7 grams of protein and virtually every single nutrient.  It may not give you all the vitamin C, but It will give you the B vitamins;  vitamin A, vitamin D, vitamin E, vitamin K1 and K2, and omega-3 fatty acids.  So this is packed full of nutrients.

Other types of protein are just like muscle protein, but egg is a very unique source of protein.

05:05.  Eggs contain Sphingomyelin.  What is that?  That's a compound that can help prevent plaquing in your vascular system.  So if you're still hung up on this idea that eggs might clog your arteries, actually they don't; they actually prevent plaquing of your arteries.  

05:22.  Choline.  Which is a really important nutrient that can help prevent a fatty liver in fact if you're deficient and choline you will get a fatty liver but Colin is also necessary for a healthy brain choline is a really good antidote to high cholesterol.

0543.  Lutein and Zeaxanthin are two compounds that greatly support the macula of the eye, that is the back part of the eye.  The macula helps you with central vision and also helps to act like a filter for UV radiation as well as filtering blue light there's a thing called age-related macular degeneration and these two compounds help prevent that condition.

06:15. Phospholipids.  

EGGS: the most bio-available of all proteins

YOU NEED FAT-SOLUBLE VITAMIN A IF YOU'RE CONSUMING HIGH AMOUNTS OF PROTEIN

Protein Powder? you don’t do pea protein/vegan but do whey or egg white based? Read this- “…The problem with whey is that it eats up concrete, so you can’t put it in the sewers. But not to worry; the industry has figured out how to turn this substance…”  https://t.co/TUv5sd0CoO

— Wejolyn 🇺🇸 (@Wejolyn) March 14, 2022

Retinol is the fat-soluble vitamin A; Retinol Palmitate is the esther form of it.  

PROTEIN & VITAMIN A

We need look no further than Chris Masterjohn’s article, “Vitamin A, The Forgotten Bodybuilding Nutrient” (Wise Traditions, Fall 2004). As Masterjohn explains, “The utilization of protein requires vitamin A. Several animal studies have shown that liver reserves of vitamin A are depleted by a high dietary intake of protein, while vitamin A increases in non-liver tissues. One explanation for this is that adequate protein is necessary for vitamin A transport. In one study, researchers fed radioactively-labeled vitamin A to rats on low-protein and high-protein diets, using the amount of radioactivity present in exhaled gases, urine and feces as a measure of the metabolism of vitamin A, and found that vitamin A is indeed used at a higher rate on a high-protein diet.”

Masterjohn continues, “Vitamin A is not only depleted by a high intake of protein, but it is also necessary for the synthesis of new protein, which is the goal of the bodybuilder. Rats fed diets deficient in vitamin A synthesize protein at a lower rate than rats fed adequate vitamin A. Cultured skeletal muscle cells increase the amount of protein per cell when exposed to vitamin A and D, but not when exposed to vitamin D alone.”

In other words, eating lean meat or taking a protein powder sends a signal to the liver: “Send me vitamin A!” Protein consumed in the absence of fat, with its precious cargo of fat-soluble vitamins, including vitamin A, is an effective way of rapidly depleting your liver of vitamin A stores.

What happens when the liver becomes depleted of vitamin A, so that none can be made available to the body when needed?

Vitamin A is key to almost every process in the body—the concert master, so to speak—not only for protein synthesis, but also for hormone production (including sex hormones like testosterone, and thyroid hormone); vitamin A is also key to immune system function, critical for healthy vision and hearing, plays a role in bone health, and works in tandem with vitamins D and K2 for everything from the prevention of heart disease to the production of feel-good chemicals. A diet of lean meat, or one that incorporates protein powders, is a recipe for hormone disruption, fatigue, depression, bone problems, auto-immune disease, vision and hearing problems, heart disease and even cancer.