DORIS LOH: Clinical evidence for high-dose melatonin at 50 mg/kg in one single dose is safe for patients undergoing liver resection. Melatonin treatment resulted in shorter ICU stay and total hospital stay

Clinical evidence for high-dose melatonin at 50 mg/kg in one single dose is safe for patients undergoing liver resection. Melatonin treatment resulted in shorter ICU stay and total hospital stay. https://t.co/qXaKkYnCBu

(50 mg/kg for a 70 kg person = 3500 mg in one single dose). pic.twitter.com/HPN5ObA6zy

— Doris Loh (@DorissLoh) August 12, 2024

From General Surgery UCSF,

Most hepatectomies are performed for the treatment of hepatic neoplasms, both benign or malignant. Benign neoplasms include hepatocellular adenoma, hepatic hemangioma and focal nodular hyperplasia.The most common malignant neoplasms (cancers) of the liver are metastases; those arising from colorectal cancer are among the most common, and the most amenable to surgical resection. The most common primary malignant tumour of the liver is the hepatocellular carcinoma. Hepatectomy may also be the procedure of choice to treat intrahepatic gallstones or parasitic cysts of the liver.

Liver surgery is safe when performed by experienced surgeons with appropriate technological and institutional support. As with most major surgical procedures, there is a marked tendency towards optimal results at the hands of surgeons with high caseloads in selected centres (typically cancer academic medical centers and transplantation centers).

DORIS LOH: in vivo peer-reviewed study showing exogenous melatonin supplementation increases endogenous production, in addition to normalizing abnormal effects from radiation exposure at the embryonic stage.

An in vivo peer-reviewed study showing exogenous melatonin supplementation increases endogenous production, in addition to normalizing abnormal effects from radiation exposure at the embryonic stage. https://t.co/iC2yrQOIIm pic.twitter.com/aDdnAPAonC

— Doris Loh (@DorissLoh) October 7, 2024

SARS-CoV-2 can upregulate NLRP3 inflammasomes in the brain to induce neurodegenerative disorders, including Parkinson's disease. Melatonin targets NLRP3 inflammasomes. Now you know why MEL is effective against brain fog and memory loss after C-19 infections

SARS-CoV-2 can upregulate NLRP3 inflammasomes in the brain to induce neurodegenerative disorders including Parkinson's disease https://t.co/BxIFXMAPuQ Melatonin targets NLRP3 inflammasomes. Now you know why MEL is effective against brain fog and memory loss after C-19 infections. pic.twitter.com/mFst6FHpN9

— Doris Loh (@DorissLoh) November 10, 2022

High dose melatonin is best for anti-oxidant powers and less for sleep inducement.  But if you're interested, you should read everything about amazing melatonin by Doris Loh.   

For over 2 billion years, melatonin was synthesized by archaea and bacteria, the two major domains of life on earth. But it’s function could not be an antioxidant because there was simply not enough oxygen to produce reactive oxygen species that can cause cellular damage. [⅔] pic.twitter.com/wAybsgnp0L

— Doris Loh (@DorissLoh) July 25, 2024

"The Mitochondria Chronicles of Melatonin and ATP: Guardians of Phase Separation," Dorish Loh and Russel J. Reiter, 2016.

Dysfunction in regulation of condensates drive neurodegeneration, cancer, and viral infection. Melatonin is a regulator of biomolecular condensates,

Biomolecular condensates are the holy grail in drug discovery because they allow access to undruggable pathways and targets. Dysfunction in regulation of condensates drive neurodegeneration, cancer, and viral infection. Melatonin is a regulator of biomolecular condensates, 1/2 pic.twitter.com/u05RjNvDAO

— Doris Loh (@DorissLoh) August 18, 2022

The journal Nature explains,

Biomolecular condensates are micron-scale compartments in eukaryotic cells that lack surrounding membranes (they're self-forming) to concentrate proteins and nucleic acids. These condensates are involved in diverse processes, including RNA metabolism, ribosome biogenesis, the DNA damage response and signal transduction. 

Melatonin is a powerhouse compound.  Amazing. 

 

And this the creator made the organizing concept of these organelles pretty clear and fun.

AA can depolarize light and other EMF wavelengths. This is why nature uses it to protect cells from potentially harmful EMFs and why mitochondria express high levels of AA transporters in humans

This is a photograph of ascorbic acid (AA) crystals using crossed polarizing filters. AA can depolarize light and other EMF wavelengths. This is why nature uses it to protect cells from potentially harmful EMFs and why mitochondria express high levels of AA transporters in humans pic.twitter.com/u0GeBJ7a3R

— Doris Loh (@DorissLoh) November 5, 2022

If plants use melatonin to defend against viruses, do you think it odd that animals and humans would not do the same?

Science is uncovering, slowly but surely, all the excellent reasons why melatonin is produced not only in animals, but also plants.

If plants use melatonin to defend against viruses, do you think it odd that animals and humans would not do the same? https://t.co/HlBUG8YFkS pic.twitter.com/Rv3Yx5wJyM

— Doris Loh (@DorissLoh) February 14, 2023

MELATONIN INHIBITS VENOM TOXICITY 100% AT 1:10 RATIO (VENOM: MELATONIN)

This melatonin molecule is proving to be indispensable, anytime, anywhere. pic.twitter.com/6edp7i9A2g

— Doris Loh (@DorissLoh) September 27, 2023

Could be impossible to overdose on Melatonin.

AMAZING MELATONIN

Concerned about potential cytotoxicity via exposure to snake venom? Look no further than melatonin, the ancient antioxidant that works for every imaginable condition. https://t.co/Up25hk8Gz1
if you are actually bitten by a snake, please seek medical help after you take melatonin pic.twitter.com/udb94NUC9t

— Doris Loh (@DorissLoh) April 14, 2022

LINE1 derepression to cause premature aging syndromes. Melatonin can inhibit LINE1 depression.

SARS-CoV-2 infection can lead to LINE1 derepression resulting in global hypomethylation and genomic instability. https://t.co/RAlGsstZL4. A new peer-reviewed paper identified LINE1 derepression to cause premature aging syndromes. Melatonin can inhibit LINE1 derepression. Amazing! pic.twitter.com/rY6FNPmZLx

— Doris Loh (@DorissLoh) August 11, 2022

MELATONIN COMBINED WITH ATP FIGHTS CATARACTS

When a journal crafts a video to promote your manuscript, you know you are on to something a bit out of the ordinary.  https://t.co/QJ3GFWPxmI

— Doris Loh (@DorissLoh) March 28, 2024

Here is the paper.  

Is there a connection to 5G?

Does 5G exacerbate #LongCovid? In Feb 2020, I presented the hypothesis of membrane depolarization by nnEMF to exacerbate C19 infections. https://t.co/G2mWb58mt6
Is it a coincidence that mitochondrial membranes of leukocytes of LongCOVID patients are also depolarized ? [1/2] pic.twitter.com/A5DR72GWuR

— Doris Loh (@DorissLoh) April 6, 2022

Melatonin is just too smart for most people to get.

A recent-peer-reviewed paper explains just how 'smart' melatonin can be when it comes to being a pro-oxidant to kill cancer cells. Many thanks to authors for including my work on melatonin regulation of prion protein that increases ROS to kill cancer cells.  https://t.co/xPZsc8j5Uh pic.twitter.com/d7fwDJVyHl

— Doris Loh (@DorissLoh) August 23, 2022

Anti-Aging Melatonin to the Rescue

Just published peer-review study found infection by SARS-CoV-2 regardless of disease severity to induce compromised lung physiology equivalent to 15 years of aging. https://t.co/BwPRNc5hta What is decreased in aging? Melatonin. https://t.co/5z8jAyQvCd Can MEL prevent C19 aging?

— Doris Loh (@DorissLoh) September 29, 2022

Be sure to get a second opinion on the anti-aging benefits of melatonin.  Dr. Russel Reiter says, 

I have a supply of melatonin with me at all times.  If I have a stroke or heart attack, I'll immediately load up on melatonin.  Based on what I know, I will take all the melatonin I can, as fast as I can.

If you don't have adequate melatonin, you can lose some glutathione

If MB oxidizes melatonin, what happens if you don't have adequate melatonin?
You can lose some glutathione,     https://t.co/24TC2XVQQa

or end up with some 8-OHdG and/or DNA strand breaks,   https://t.co/kTLQFSWspH

especially if you use photobiomodulation. https://t.co/3lJDpvUlTM

— Doris Loh (@DorissLoh) July 17, 2023

STUDY SHOWS: Melatonin improves glucose homeostasis and rescues/regenerates damaged pancreas beta-cells. How is this possible?

Why would melatonin increase insulin in one study using diabetic rats but decrease insulin in another study using the same type of animal model?

Both studies showed melatonin to improve glucose homeostasis and rescue/regenerate damaged pancreas beta-cells. How is this possible? pic.twitter.com/fEuxTFrqeK

— Doris Loh (@DorissLoh) July 19, 2023

Higher dose can be powerful.  If you're looking for larger doses, Pure Bulk came recommended.

Melatonin . . . dose-dependently reduced viral load/entry in mouse brains, inhibiting small cerebral vessels damage and brain inflammation

Melatonin suppresses N protein phase-separated 'viral factories', is now supported by peer-reviewed evidence where melatonin/analogs dose-dependently reduced viral load/entry in mouse brains, inhibiting small cerebral vessels damage and brain inflammation.  https://t.co/aRsWnls0ZB pic.twitter.com/wL0SRpfkBv

— Doris Loh (@DorissLoh) August 17, 2022

PQQ deficiency reduces mitochondria content and mitochondrial-related gene expression.

I'm Pharma, and I'm going to capitalize on your illness by producing fake wellness. I'm going to replace Mg, Glycine, Cysteine, Omega 3s, PQQ, CoQ10 etc with a toxic substance. Stay tuned for our latest snake oil coming to a drug store near you. pic.twitter.com/OaB7CfTwyk

— DCGreenZone1 (@DCGreenZone) August 4, 2022

PQQ.  So what is it?  It's an antioxidant.  PQQ stands for pyrroloquinoline quinone and was first recognized as an enzyme cofactor in bacteria by Norwegian biochemist Jens Hauge in 1964.[iii] It wasn’t until 2003 that Japanese brain researcher Tadafumi Kato found that PQQ also occurs in rodents and other mammals, including humans.

As an enzyme cofactor, PQQ, is critical to the life of your brain cells.  And some would say it's even critical to life itself.  "Cofactors" are molecules that act as a helper for enzymes that need assistance to work properly.  

What gives me pause about all of these antioxidants is that each one claims to be the most powerful antioxidant.  Each one.  From Acai berry to olive oil to melatonin and now PQQ.  I'm not saying that they're not powerful each and every one of the, including vitamin E and vitamin C.  But jeez, we've got to find a way to cut through the claims.  Doris Loh does some excellent work on the incredible benefits of melatonin.  Her website is here, but I really like her Twitter feed.  

"Ultraviolet C Band of light had germicidal properties due to it’s ability to break apart the DNA of organic matter"

MEL continues to impress. New peer-reviewed study reports the formation of potent antioxidant metabolite N1‐acetyl‐5‐methoxykynuramine (AMFK) upon exposure to UVC irradiation. This means: cytotoxic UVC will create more antioxidant protection via AMFK if MEL is present #MedTwitter pic.twitter.com/cY46zGMTyQ

— Doris Loh (@DorissLoh) October 31, 2022

UVC is a particular wavelength of light.  

All three bands have germicidal properties that make them beneficial for multiple applications in facility management, including:

Coil Irradiation in HVAC systems to boost energy efficiency and reduce maintenance.

Air Disinfection through the use of Upper Air Germicidal Irradiation units, which is very effective at controlling the spread of influenza virus, the common cold, and most every other airborne pathogen.

Surface Sterilization is a newer application and there are a variety of devices sold that claim to do this.  Although the technology is sound the efficacy of how the different systems deliver the UV-C light to the surfaces to be sterilized/decontaminated is questionable.

It was discovered way back in the 1890’s that the Ultraviolet C Band of light had germicidal properties due to it’s ability to break apart the DNA of organic matter.

HDIVC [High Dose Intravenous Vitamin C] + Ascorbic Acid + Melatonin

In clinical trials for critically-ill patients, using only HDIVC may not be adequate without supplementation with oral ascorbic acid containing the correct molecular combination used for redox processes. What happens if a patient cannot ingest AA?
Easy. Use IV melatonin instead. pic.twitter.com/6Oxhq1A0Ny

— Doris Loh (@DorissLoh) August 13, 2022