WALTER M. CHESTNUT: Friday Hope: Curcumin II: Inhibiting SARS-CoV-2, its Spike Protein… and PRIONS

Friday Hope: Curcumin II: Inhibiting SARS-CoV-2, its Spike Protein… and PRIONS by Walter M Chesnut

A new review highlights how Curcumin is almost certainly one of the most important supplements of our times.

Read on Substack

There is no way of getting curcumin without getting some kind of seed oil, either sunflower oil or the capsules themselves are made of a pharmacological vegetable made in a lab by one of the big pharma companies.  It's use at your own risk.  The preferred option is to get the turmeric root from the health food produce section at your Sprouts, Whole Foods, or Natural Grocers. 

Life Extension Curcumin Elite Turmeric Extract – 270x Better Absorption Than Standard Curcumin, Support A Healthy Inflammatory Response, Gluten Free, Non-GMO, Vegetarian—30 Vegetarian Capsules https://t.co/N0e1FiuqCn via @amazon

— St. Michael, the Archangel (@aveng_angel) April 19, 2024

mRNA vaccines contain the genetic code to make spike protein. The RNA is carefully engineered to resist breakdown (PEGylated)

The va☠️☠️worse than glyphosate!
Dr Seneff, known for her ground breaking research on glyphosate, gives talk on the cl0t sh0t!
The spike protein as a prion.  https://t.co/6bjPkBZMOb

— Own Silver to say: I do not comply ! Steve_AG WSS (@RightsSpiritual) January 8, 2022

Seneff is speaking with the World Council for Health.

mRNA vaccines contain the genetic code to make spike protein. The RNA is carefully engineered to resist breakdown (PEGylated)

all of the uridines are replaced with 1-methyl-pseudouridine (m1Y)

the mRNA is incorporated into a lipid particle that simulates a human LDL particle.

A synthetic cationic (positively charged) lipid is added to act as an adjuvant—very toxic to the cells.

The “humanized” mRNA is a stealth entry system for the massive production of spike proteins.

THE BIG PICTURE

A natural infection starts in the nose and lungs and never makes it into general circulation if the immune system is healthy.

Injection of spike mRNA nanoparticles into deltoid muscle bypasses mucosal and vascular barriers.

Immune cells take up mRNA nanoparticles and carry them into the lymph system, ultimately into the spleen.  It’s all been set up so that it can’t be controlled or shut down.  The vaccines are very successful in producing a huge antibody response. 

Immune cells in the spleen release large quantities of spike protein displayed on the surface of exosomes.

These exosomes disperse throughout the body, but, especially travel to the brain along nerve fibers to deliver the toxic prion-like spike protein to neurons and the brain. 

The inflammatory response in the brain induces neurological damage. 

“Is COVID-19 a Perfect Storm for Parkinson’s Disease?”  Patrik Brundin, Avindra Nath, and J. David Beckham.

Loss of smell is a common early symptom of Parkinson’s and of COVID-19.

The virus can gain access to the brain along nerve fibers.

        Along the olfactory nerve, the virus can gain access to the brain.

        Vagus nerve

Neuroinvasion of SARS-COV-2 could upregulate a-synuclein:

        High levels of a-synuclein lead to misfolding and toxicity.

Dopaminogenic neurons in substantia nigra express high levels of the ACE2 receptor. 

PARKINSON’S IS PRODUCED IN THE GUT

Parkinson’s disease often begins in the gut as an immune reaction to prion-like proteins produced by pathogens.

The spike protein is a prion-like protein.

It contains 6 glycine zippers (GxxxG)—a characteristic signature of prions (The human prion protein contains 15, and amyloid-beta (linked to Alzheimer’s disease) contains only 4.

Stressed immune cells in the digestive tract and spleen upregulate a-synuclein and release it packages up in exosomes, along with foreign misfolded proteins.

The exosomes travel along the vagus nerve to the brain stem nuclei.

Damage to the substantia nigra causes Parkinson’s disease.

The whole process can take years or decades before symptoms appear. 

S. Seneff and G. Nigh IJVTPR 2021; 2(1):38-79.

 

Paper from India:  Ritu Mishra and Akhil C. Banerjea.  Frontiers in Immunology 2021; 12:656700.

“SARS-CoV-2 Spike Activates Human Microglia in the Brain via Exosomes Loaded with miRNAs.”

It transfected cells to DNA code to make their own spike protein. 

SARS-CoV-2 spike transfected cells release a significant amount of exosomes loaded with microRNAs such as miR-148a and miR-590.

MicroRNAs get internalized by human microglia in the brain.

        Induce a strong inflammatory response.

These results uncover a bystander pathway of SARS-CoV-2 mediated CNS [central nervous system] damage through hyper-activation of human microglia

Exosomes will produce cells loaded with miRNAs.  These miRNAs are very strong, controlling signaling molecules that will cause immune cells to produce an inflammatory response.  And so these get internalized by these microglia in the brain.  And this induces a strong inflammatory response, which will lead to brain swelling, brain damage, and all these bad things.  To quote them, “These results uncover a bystander pathway of SARS-CoV-2 mediated CNS [central nervous system] damage through hyper-activation of human microglia.”

Figure 1.  Marianna D’Anca et al.  Frontiers Aging Neuroscience 28 August 2019;11:232.

The donor cell can be very far away from the recipient cell.  And the donor cell would be that all these nuclei in the brain get exposed by these exosomes and be taken up by these cells and [or] in the brain.  And then those miRNAs can be exposed to follicles to changes and then induce inflammatory changes in the brain. 

Norbert Pardi et al.  J. Exp Medicine.  2018 Volume 215 No. 6 1571-1588.  Juliane Bremer et al., PLoS ONE 2009; 4(9): e7160.

“Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal B cell responses”

“Nucleoside-modified” means that all the uridines in the mRNA were replaced with 1-methyl-pseudouridine.

This replacement resulted in a robust synthesis of protein from the mRNA code (protected RNA from degradation)

The result was a very strong antibody response due to the formation and maintenance of germinal centers in the spleen. 

Another study showed that repeated exposure to antigen (foreign protein) through immunization resulted in increased susceptibility to prion protein exposure.

Attributed to an expansion of splenic germinal centers.  26:51.