SAMA HOOLE: Testosterone is made from cholesterol. Oestrogen is made from cholesterol. Cortisol is made from cholesterol. Vitamin D is made from cholesterol. Bile acids that digest fat are made from cholesterol.

Testosterone is made from cholesterol.

Oestrogen is made from cholesterol.

Cortisol is made from cholesterol.

Vitamin D is made from cholesterol.

Bile acids that digest fat are made from cholesterol.

Progesterone, which sustains pregnancy, is made from cholesterol.

Every…

— Sama Hoole (@SamaHoole) May 17, 2026

Testosterone is made from cholesterol. Oestrogen is made from cholesterol. Cortisol is made from cholesterol. Vitamin D is made from cholesterol. Bile acids that digest fat are made from cholesterol. Progesterone, which sustains pregnancy, is made from cholesterol. Every cell membrane in your body contains cholesterol. Every nerve is insulated by myelin, which is largely cholesterol. Every memory you form requires cholesterol to build the synapse that holds it. Your brain is 60% fat, mostly cholesterol. Breast milk is rich in cholesterol because infant brains cannot develop without it. Nature, given the job of designing the perfect first food, put cholesterol in it. When you eat less of it, the liver makes more. Because the body knows it cannot function without it. We declared war on cholesterol in 1977. Testosterone in men has dropped 25%. Vitamin D deficiency is now endemic. One in three adults over fifty is on a statin lowering the cholesterol the body is desperately trying to maintain. Depression rates have tripled. Infertility rates have doubled.

The war is going well.