P53 is the guardian of the genome, is that important?? https://t.co/ZNw5CYAbY0
— Dr. Urso (@richardursomd) January 27, 2022
The spike protein binds to the P53
and inactivates it? The spike impairs DNA damage repair.
Translation? Cancer, perhaps metastatic cancers. Nature magazine explains that
p53 is an important tumour-suppressor protein that is altered in most cancers. p53 activates various responses, including cell-cycle arrest and apoptosis. Each of these appears to contribute to tumour suppression.
P53 upregulates skin pigmentation. So vitamin D plays a coordinating role with p53 to suppress tumors.
The word mutation just doesn’t sound like something good. By definition, a mutation is a permanent change in DNA. Mutations, for the most part, are harmless except when they lead to tumor formation.
Likely you have heard about BRCA mutations. BRCA genes are tumor suppressor genes. BRCA mutations can increase one’s risk for cancers of the breast and ovaries. However, these mutations are only responsible for about 5-10% of all breast cancers and about 15% of ovarian cancers. But, the little-known p53 mutation affects far more people. About 50% of all cancers have a mutated p53 gene.
What is P53?
The p53 protein is located in the nucleus of cells throughout the body, where it attaches (binds) directly to DNA. (It is actually the TP53 gene that provides instructions for making the tumor protein p53 but for simplicity, I will say p53.) P53 regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way.P53 plays a critical role in determining whether damaged DNA will be repaired or a damaged cell will self-destruct (undergo apoptosis). If the DNA can be repaired, p53 activates other genes to fix the damage. If the DNA cannot be repaired, this protein prevents the cell from dividing and signals it to undergo apoptosis. By stopping cells with mutated or damaged DNA from dividing, p53 helps prevent the development of tumors.
Mutated P53
P53 mutations lead to a version of p53 that cannot regulate cell growth and division effectively. Specifically, the altered protein is unable to trigger apoptosis in cells with mutated or damaged DNA.DNA can be damaged by agents such as toxic chemicals, radiation such as gamma rays, X-rays — even UV light can interact with compounds in the cell generating free radicals which cause chemical damage to DNA.
Since all cells in our body contain DNA, there are lots of places for mutations such as p53 to occur. When p53 does not operate properly, damaged DNA can replicate, producing mutations and DNA rearrangements that contribute to the development of a highly transformed, metastatic cell. Many cancer cells inactivate p53, allowing the cells to evade death and continue proliferating up to becoming a tumor.
Mutant p53 proteins not only lose their tumor-suppressive activities but often escalate the development of cancerous tumors by providing them with growth and survival mechanisms. Interestingly, mutations in the p53 gene have been shown to occur at different phases of the cancer process, contributing to tumor initiation, promotion, aggressiveness, and metastasis.
Here is a list of nutritional compounds that protect and rebuild your p53 proteins.
• Cruciferous vegetables,
especially watercress
• IP6
• Resveratrol
• Herbs such as sage, rosemary, ginger, curcumin, and ashwaganda
• EFA’s from omega 3 fatty acids (please use caution with fish oil supplements
as they can be toxic). For a plant-based formula, you could take BodyBio Balance Oil.
• Licorice
• Mistletoe
• Vitamin D
• Selenium
• Vitamin C
• Zinc
• Black Seed
• Clinoptilolite (a
special form of Zeolite)
Regarding the benefits of Resveratrol, this information was compelling. On pages 9-10, check this out:
No single molecule, natural or man-made, has been proven to cure cancer. Most cancer chemotherapy consists of multiple drugs. But then again, there is resveratrol.
It was a breathtaking moment in the history of medicine. It is nearly forgotten now, but momentarily relived for readers here. A researcher had been dispatched across the globe to test and examine over 30,000 natural molecules for their ability to quell cancer. Unexpectedly, one molecule stood out from the rest.
John Pezzuto PhD, the researcher who traveled thousands of miles for the National Cancer Institute to put these natural molecules to the test, said: “Of all the plants we’ve tested for cancer chemo-preventive activity and all the compounds we’ve seen, this one has the greatest promise.”
Resveratrol blocks all three stages of cancer genesis: initiation, promotion and progression. No anti-cancer drug comes even close to doing this. Resveratrol may be as close as biologists will ever come to a singular cure for cancer. Oddly, even though resveratrol has been demonstrated in numerous studies to help overcome cancer drug resistance and to quell cancer itself, it is not even used as a secondary medication in cancer therapy today.
According to Dr. Pezzuto, a recent research study involving resveratrol showed that it switched hundreds of genes at one time. Commenting on that study, Dr. Pezutto likened resveratrol to a “whiff that induces a biologically specific tsunami.” Those are strong words from a usually reserved investigator
