SAMA HOOLE: Alcohol is hepatotoxic (damages liver), neurotoxic (damages brain), and carcinogenic (causes cancer). These effects occur at any dose. The "moderate drinking is healthy" research has been thoroughly debunked.

Alcohol metabolism produces acetaldehyde, a toxic compound that damages DNA and proteins throughout your body. 

Your liver prioritizes alcohol detoxification over every other metabolic process because alcohol is literally poison and must be cleared immediately or you die.

While your liver is processing alcohol, it cannot effectively burn fat, regulate blood sugar, or perform normal detoxification of other compounds. --Sama Hoole

There is no safe dose of alcohol. Every drink causes cellular damage.

Alcohol is hepatotoxic (damages liver), neurotoxic (damages brain), and carcinogenic (causes cancer). These effects occur at any dose.

The "moderate drinking is healthy" research has been thoroughly debunked.…

— Sama Hoole (@SamaHoole) January 10, 2026

There is no safe dose of alcohol. Every drink causes cellular damage. Alcohol is hepatotoxic (damages liver), neurotoxic (damages brain), and carcinogenic (causes cancer). These effects occur at any dose. The "moderate drinking is healthy" research has been thoroughly debunked. Those studies were confounded by abstainers including former alcoholics with existing health problems. When you control for that: No benefit at any dose. Only dose-dependent harm. Alcohol metabolism produces acetaldehyde, a toxic compound that damages DNA and proteins throughout your body. Your liver prioritizes alcohol detoxification over every other metabolic process because alcohol is literally poison and must be cleared immediately or you die. While your liver is processing alcohol, it cannot effectively burn fat, regulate blood sugar, or perform normal detoxification of other compounds. This is why alcoholics develop fatty liver even when not consuming excess calories. The liver is overwhelmed processing ethanol and cannot process fat, so fat accumulates. "But red wine has antioxidants!" The alcohol negates any potential benefit. Drink grape juice if you want antioxidants. Or eat liver for 100x more antioxidants without the poison. Every "health benefit" attributed to moderate drinking exists in greater quantity in whole foods without the cellular damage. The alcohol industry has successfully marketed their product as health food. It's not. It's recreational poison. Enjoy it if you want, but don't pretend it's healthy.

Your body treats alcohol exactly like it treats other toxins: as something to detoxify and eliminate immediately. 

CHASE HUGHES: NOREPINEPHRINE give you readiness, energy, and backbone

If Dopamine is low in the brain, shit feels pointless, a goal, or whatever feels really obvious. Planning replaces action. I'm going to do all these journals and one-year plans, little white boards. The word "tomorrow" becomes kind of a lifestyle for us.  --Chase Hughes

1:47  DOPAMINE.  People say that dopamine is pleasure.  That's a lie.  It's way completely false.  Dopamine dysregulation is the cause of Parkinson's.  It has nothing to do with pleasure.  So Dopamine is misunderstood.  Dopamine is the signal that something is worth moving toward.  So when dopamine is healthy, when I make some effort, it feels meaningful.  If I make some progress in my life, it feels real.  And the actions that I'm taking towards a goal or whatever, feel really obvious.  If Dopamine is low in the brain, shit feels pointless, a goal or whatever feel really obvious.  If Dopamine is low in the brain, shit feels pointless.  Planning replaces action.  I'm going to do all these journals and one-year plans, little white boards.  The word "tomorrow" becomes kind of a lifestyle for us.  

2:31  SEROTONIN.  The second neurotransmitter is serotonin.  

Cholesterol and saturated fats make up more than 50% of your cell membranes.

Cholesterol is an important antioxidant, enhances serotonin, maintains gut integrity, and is the precursor to many major hormones.

Why would you want to lower something that's so crucial to life?

— Sama Hoole (@SamaHoole) August 18, 2024

And the 3 words that I want you just to think about with Serotonin is control, stability, and restraint.  Serotonin is not happiness.  I want you to think of Serotonin as impulse control.  It's the chemical that lets you pause instead of just reacting to something.  It lets you delay gratification.  It lets you stick with something when it gets uncomfortable.  So when your serotonin is low, it looks like emotional volatility.  You have more anxiety.  You get pissed off more easily.  It's the "I know exactly what I should do, but I can't make myself do it."

3:10  NOREPINEPHRINE.  The 3rd chemical is norepinephrine.  Norepinephrine.  And the three words I want you to associate with this are readiness, energy, and backbone.  This is the one that people confuse with stress.  But if you look at norepinephrine, it's regulated intensity.  Healthy levels of norepinephrine feel like an alert sense of calm, like you're more resilient to stress and like a readiness to act if something happens.  Low norepinephrine is brain fog, avoidance, learned helplessness, fatigue that sleep won't fix.  And if your norepinephrine is too high, we have anxiety, and panic and burnout, and definitely, definitely going to get some insomnia there.  

Let me kill one more myth here, and this is a big one I had written down.  Vitamin  and mineral deficiencies don't just happen to malnourished kids in Somalia.  They happen to people that are stressed, that live a busy life, that are disciplined, people who push through stuff, people who skip meals, people who sleep like shit, people who live on a whole lot of caffeine, adrenaline.  I want you to write this one thing down: Stress burns nutrients.  And if I had [fewer] nutrients, I have inflammation.  And inflammation blocks the absorption even further, and then sleep deprivation wrecks our receptor sensitivity, the receptors that we need to absorb all this good stuff.  So you can eat the most perfect diet ever and still be super depleted.

SCOTT JENNINGS: So basically we have numerous blue states that are, at a minimum, in a rhetorical state of secession from the Union. Wild. All because they don’t want to enforce federal immigration laws.

Civil War 2.0 https://t.co/33eKik1kt7

— Tom Luongo (@TFL1728) January 10, 2026

So basically we have numerous blue states that are, at a minimum, in a rhetorical state of secession from the Union. Wild. All because they don’t want to enforce federal immigration laws. https://t.co/ovrJJ2IqiA

— Scott Jennings (@ScottJenningsKY) January 9, 2026

AMERICAN AF: Seattle Mayor, trying to breathe life into George Floyd 2.0, has officially declared war on ICE agents.. She needs to be ARRESTED!

Seattle Mayor has officially declared war on ICE agents..

She needs to be ARRESTED! pic.twitter.com/zIYEK8AhhS

— American AF 🇺🇸 (@iAnonPatriot) January 10, 2026

ANDY NGO: The entire city and state leadership, all run by Democrats, organized an emergency press conference to condemn the federal agents, reject DHS' statement and to express support with the violent suspects, who they called the "victims."

Two Latinos were shot in Portland a day after Eileen Good in Minneapolis by Border Police and ICE agents.  They were injured, but the injuries were not fatal.  No one died.  The Latinos were shot at because they were using their vehicle as a weapon and accelerated at the border patrol police.  And it was learned afterwards that the two Latinos are members of the Venezuelan gang, Tren de Aragua.  So there's that.  I'm sure it's nothing.  

In an odd twist of almost everything, Portland Chief of Police, Bob Day, used his presser to cry crocodile tears in defense of the Latino comunidad and over how members of his community, meaning police in every city in America, have historically not listened to Latino voices.  Weep, weep, sniff, sniff. 

Portland Police @ChiefBobDay cries at a press conference after having to affirm that @DHSgov was correct in stating that the illegal Venezuelan migrants accused of trying to run down Border Patrol have ties to Tren de Aragua. Chief Day admitted that he hesitated to share the… pic.twitter.com/wxdT53yWsD

— Andy Ngo (@MrAndyNgo) January 10, 2026

Portland Police @ChiefBobDay cries at a press conference after having to affirm that @DHSgov was correct in stating that the illegal Venezuelan migrants accused of trying to run down Border Patrol have ties to Tren de Aragua. Chief Day admitted that he hesitated to share the truth with the public.

On Jan. 8, Border Patrol non-fatally shot a man and a woman in east Portland after they allegedly tried to run down agents in a red pickup truck following a targeted stop. Internal communications about the incident, which was inaccurately blamed on ICE, were leaked to PDX ICE Watch by a Multnomah County first responder.

The entire city and state leadership, all run by Democrats, organized an emergency press conference to condemn the federal agents, reject DHS' statement and to express support with the violent suspects, who they called the "victims." Local and national media also misled the public about the shooting. A mob showed up to try to attack the ICE facility, leading to six arrests. 

Read more:

Check out "Who Is the Suspected Tren de Aragua Sex Ring Operative in Alleged Border Patrol Portland Truck Attack?" Andy Ngo, Ngo Comment, January 9, 2026.

Michelle Del Rey produces a decent short review of Tren de Aragua at USA Today,

Two people who the Department of Homeland Security (DHS) says have ties to a Venezuelan gang were shot by Border Patrol agents on Jan. 8 during a vehicle stop in Portland, Oregon.

The gang, Tren de Aragua, was designated as a Foreign Terrorist Organization (FTO) by the U.S. Department of State in 2025.

“Tren de Aragua is a terrorist cartel that exploits our borders to bring murder, drugs, and chaos into American communities,” Deputy Attorney General Todd Blanche said in December following the announcement of a nationwide crackdown on the gang.

Luis David Nico Moncada and Yorlenys Betzabeth Zambrano-Contreras − the two individuals in Portland who DHS said had possible connections to a the gang − were shot after the driver attempted to "weaponize" his car and run agents over, the agency said in an X post on Jan. 8.

. . . 

The gang originated in a Venezuelan prison and has since developed into a “transnational criminal organization” led by Hector Rusthenford Guerrero Flores, also known as "Niño Guerrero," according to the U.S. Department of State and Immigration and Customs Enforcement.

The State Department said Guerrero Flores used his time in prison to expand the gang’s influence. As a result, Tren de Aragua has managed to gain control of gold mines in Venezuela and drug corridors on the Caribbean coast, a notice released by the department states.

Federal authorities have claimed that the gang also operates in Chile, Peru and the U.S. In December, Guerrero Flores was charged in a Manhattan federal court with racketeering, terrorism, drug importation and firearms offenses.

“As alleged, Hector Rusthenford Guerrero Flores has been the mastermind of Tren de Aragua’s evolution from a Venezuelan prison gang into a transnational terrorist organization that committed countless acts of violence, extortion, and drug trafficking all over North America, South America, and Europe,” U.S. Attorney for the Southern District of New York Jay Clayton said in a statement.

https:uspected-tren-de-aragua