Showing posts with label Walter M Chesnut (@Parsifaler). Show all posts
Showing posts with label Walter M Chesnut (@Parsifaler). Show all posts

Thursday, September 1, 2022

In contrast to conventional studies of amyloidogenic drugs, quercetin accelerates fibrillation of prion protein. (A GOOD thing.)

QUERCETIN

Some highlights regarding Quercetin and amyloids:

Quercetin binding to prion protein is determined, and the network of the binding site at the molecular level is visualized.

In contrast to conventional studies of amyloidogenic drugs, quercetin accelerates fibrillation of prion protein. (A GOOD thing.)

Quercetin turns fibrils into protease-sensitive, structurally loose and non-cytotoxic forms.

Quercetin shows its uniqueness from typical antiamyloidogenic drugs.

Quercetin treatment can disaggregate moPrP (mouse prion) fibrils and lead to the formation of the proteinase-sensitive amorphous aggregates. Furthermore, quercetin-bound fibrils can reduce the membrane disruption of erythrocytes.

Quercetin is distinct from the typical function of antiamyloidogenic drugs that inhibit the formation of amyloid fibrils.

CURCUMIN

Curcumin may be a powerful alloy and “wing man” to Quercetin.

Curcumin alone reduced prion fibril formation significantly.

Curcumin effectively rescues the cells from apoptosis and decreases the ROS level caused by subsequent co-incubation with prion amyloid fibrils.

I believe urgent clinical trials are needed to assess the efficacy of Quercetin and Curcumin as prophylaxis, and treatment of both Acute and Long COVID.

https://www.sciencedirect.com/science/article/pii/S0753332222005662#

https://pubmed.ncbi.nlm.nih.gov/33187342/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235698/

Thursday, March 31, 2022

Spike protein causes the glial cells, the repair cells in your brain, to self-destruct

Okay, this is not good.  None of the news coming from vaccinated individuals is good.  It's going to require a lifetime of care.  The spike protein crosses the blood brain barrier, BBB, and produces cognitive deficits and psychiatric problems.  Meaning that you'll lose your mind unless you slow this process down by consuming neuroprotective nutrients, like fish oils, like the whole spectrum of B vitamins.  B5 for youthfulness and longevity.  B6 for healthy micro gut biome. B12 for nerve regeneration.  Far-soluble B1 [Allithiamine, lipothiamine, and or benfotiamine] to protect your autonomic nervous system that automatically regulates all of your vital organs.  See this post.  What follows is extracted from the tweet above.

People worldwide are currently suffering from the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1,2. Increasing evidence has shown that COVID-19 patients not only manifest respiratory-related symptoms, but also develop neurological and psychiatric symptoms, depending on the stage of infection, ranging from headache to cognitive and mood disorders3,4. According to clinical studies, 19% and 14% of COVID-19 patients develop depression and anxiety, respectively5 and 10–20% suffer from cognitive impairment6. Therefore, it is obvious that SARS-CoV-2 somehow affects the central nervous system (CNS), but the molecular and cellular mechanisms are still elusive. Previous studies suspected direct SARS-CoV-2 infection into the CNS, as SARS-CoV-2 spike protein and transcripts were detected in post-mortem brains. Then, as a port of CNS entry, SARS-CoV-2 invasion via olfactory receptor neurons was proposed7. However, a recent study using unbiased transcriptome analysis of the post-mortem brain tissue of COVID-19 patients did not succeed in detecting molecular traces of SARS-CoV-2 virus in the brain parenchyma8 negating direct SARS-CoV-2 infection into the CNS parenchyma. More recently, it was reported that intravenously administered radiolabeled S1 subunit of SARS-CoV-2 spike protein (S1 protein) can translocate into brain parenchyma by crossing the blood–brain barrier9. Therefore, this suggests the possibility that S1 proteins translocated into the brain parenchyma may affect brain functions, which might underlie the neurological or psychiatric symptoms of COVID-19 patients. The possibility was examined by introducing S1 proteins into mouse brains. We showed that the injection of S1 protein into mouse hippocampus induced cognitive deficits and anxiety-like behaviors. As mechanisms, we found that SARS-CoV-2 S1 protein exerted non-cell autonomous hippocampal neuronal cell death by inducing interleukin-1 beta (IL-1β) expression from glial cells

Wednesday, January 12, 2022

SPIKE PROTEINS ON CELL SURFACE MIMIC RADIATION POISONING

EducateInspireChange over at The Natural Health Page compiled a list of foods that can remove uranium and mercury from your organs and blood.  He writes, 

Here is a list of 10 foods that can be used to help protect your body against the harmful effects of radiation:

Cilantro

Helps remove heavy metals from the bloodstream. It draws lead, uranium, and mercury from your organs and blood which helps assist the kidneys in flushing out your system.

Red Beets

Studies have shown that beets can help aid the body in rebuilding damaged haemoglobin. With radiation exposure, haemoglobin gets broken down, so it is important to protect our blood systems at all costs. Eating beets has actually been found to help absorb and detox radioactive isotopes in studies with animals.

Dandelion

Dandelion is an amazing plant! Most of us don’t think twice when we rip them out of our lawns because they are considered “weeds” and not “aesthetically pleasing” but these plants are detox miracles. It helps keep free radicals at bay and ensures a healthy functioning liver (which ensures that toxins are properly eliminated from the body).

Apples & Sunflower Seeds

Apples and sunflower seeds contain high levels of pectin which helps to bind and remove radioactive residues from the body. Particularly, these two foods protect against caesium-137 which collects in the endocrine glands, pancreas, thymus, and heart. Caesium-137 emits gamma rays, as well as beta rays which are incredibly toxic to the cells in our body. Consuming plenty of apples, and a healthy amount of sunflower seeds is a perfect snack addition to your day and can help protect your body from radiation.

Burdock Root

This root helps remove radioactive isotopes from the body! Consuming 1-4 ounces (120-300 grams) of fresh burdock root, whether lightly cooked in a tea infusion or juiced using a juicer (this is the best method because raw is always best – enzymes are not destroyed) can help reverse and prevent the DNA damage done by radiation.

Leafy Greens

All greens contain the molecule chlorophyll which is incredibly alkaline and helps provide protection from radiation damage. Since the early 1950s, studies have proven the miraculous effects of chlorophyll and radiation. These effects are even greater when darker green vegetables like mustard greens, and alfalfa leaves as well as kale and collards are used. Consuming two or more green vegetables together gives the greatest radiation resistance.

Buckwheat

Glucosides in buckwheat can help protect from radiation exposure if consumed before radiation exposure has occurred. Cereal grasses help to cleanse our bodies of radiation in a similar way that other green foods do like leafy greens (rich in chlorophyll) and blue-green algae.

Ginseng

A great way to protect and treat yourself from radiation is ginseng! Ginseng’s ability to help heal radiation damage is still being studied, but preliminary studies have pointed to the conclusion that it is a wonderful healing agent for any type of radiation exposure. Consuming between 100 to 200mg of ginseng twice per day was found to help speed up the recovery of individuals exposed to radiation (healing of bone marrow, skin, internal organs, and blood cells).

Rosemary

Compounds in rosemary fight against the mutagenic effects of radiation. Studies have shown that the carnosic acid and carnosol found in rosemary allow it to provide this anti-mutagenic effect. As well, rosemary was found in another study to be 3.34 times better at protecting against radiation effects than a variety of other compounds studied.

For each claim, he cites the following sources from LiveLoveFruit

http://rt.com/news/japan-nuclear-leak-upgrade-100/.

http://www.globalhealingcenter.com/natural-health/natural-remedies-for-radiation-exposure/.

http://www.ncbi.nlm.nih.gov/pubmed/19446548

http://www.naturalnews.com/026079_radiation_exposure_rosemary.html.

http://www.naturalnews.com/032770_ginseng_radiation.html.

Use apple pectin for radiation exposure.    

https://www.naturalbioenergetics.com/blog-posts/radiation/ by Dr. Jimmy Scott.

Friday, November 26, 2021

Soluble ACE2 reduces viral load from 1000 to 5000 times

"ACE2 thereby helps to protect multiple tissues such as the lung, blood vessels, heart, or kidney, and inactivation of ACE2 results in severe disease pathologies in these organs including diabetic nephropathies. ACE2 has also been identifying as the critical receptor for the Spike proteins of SARS-CoV and SARS-CoV2 and is intricately involved in SARS and COVID-19 pathogenesis."

This video was released on February 3, 2021. 

ACE2 Receptors protect against heart disease.  ACE2 is heavily expressed in the lungs, and we didn't know what it was doing.  Severe inflammation and increased vascular permeability in ACE2 knockout mice in ARDS, or Acute Respiratory Distress Syndrome.  

PubMed explains that 

Soluble angiotensin-converting enzyme 2 (sACE2) could be a therapeutic option to treat coronavirus disease 2019 (COVID-19) infection. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes ACE2 receptors on cell surfaces to gain intracellular entry, making them an ideal target for therapy. High-affinity variants of sACE2, engineered using high-throughput mutagenesis, are capable of neutralizing COVID-19 infection as decoy receptors. These variants compete with native ACE2 present on cells by binding with spike (S) protein of SARS-CoV-2, making native ACE2 on cell surfaces available to convert angiotensin II to angiotensin-1,7, thus alleviating the exaggerated inflammatory response associated with COVID-19 infection. This article explores the use of sACE2 as potential therapy for COVID-19 infection. 

At the 8:51 mark, he cites Yumiko Imai's findings of the function of ACE2 receptors, and you can check out that discussion here.  Besides ACE2 receptors, other receptors were reported in cell lines, like the cell membrane protein, L-Sign/CLEC4M.  But he learned that the ACE2 receptor is essential for Coronavirus infection; no ACE2 receptor, no COVID.  Check this out, 

SARS infection downregulates, lowers the rate or level of, ACE2 expression in the lungs.  The ACE2 receptor disappeared in the lungs and in the heart.  The virus binds to ACE2 and takes it with it into the cell, where the ACE2 is being degraded.  The virus more or less creates an ACE2 mutant background.  And this was interesting becauase it gave us a molecular understanding of how the SARS-CoV-2 became such a killer virus because of various injuries in the lung.  

14:07  ACE2 as therapy for acute lung injury.  If this is the acase, then we can create an enzyme replacement therapy.  

Biotech company in Vienna, Apeiron Biologics, developed a soluble Recombinant Angiotensin Converting Enzyme System 2 molecule APN01 for therapeutic use against lung failure.  Lung failure is an end stage of many diseases-sepsis, gastric aspiration, the Spanish Flu, bird flu, bioterrorist agents.  This moleculre actually went through 89 humans already, healthy volunteers in Phase I trials and in Phase II trials.  Also into people who had lung disease.  

Just to show you there's some that actually developed with Glaxo-Smith Kline with older rights belong to us--to us meaning this biotech in Vienna, Apeiron Biologics.  So Glaxo-Smith Kline is not involved with this anymore.  

It's a key regulator of the Renin-Angiotensin System, which in turn regulates blood pressure.