Showing posts with label FOLIC ACID. Show all posts
Showing posts with label FOLIC ACID. Show all posts

Thursday, May 10, 2018

AN ANNOUNCEMENT THAT BENFOTIAMINE CURES AND PREVENTS ALZHEIMER'S IS EXPECTED SOON

A few quotes from Bill Sardi.  

One,
There is a doctor in Italy who is astonishingly curing Parkinson's disease with B1 shots (mostly among alcoholics).   
Two, 
Because of poor absorption, it is unlikely the best diet or fortified foods can overcome a state of B1 deficiency. 
Three,
Vitamin B1 is well provided but just not absorbed or is rapidly excreted (diuretics). 
Four, 
An announcement of the highly absorbable fat-soluble form of vitamin B1 (Benfotiamine) cures and prevents Alzheimer's disease is expected soon
And Five,
One of the ways widespread nutritional deficiencies remain hidden is that blood tests only reveal what is called the reference range (commonly occurring range), not the healthy range.
I remember sitting in an Anatomy class at UC Irvine back in 1990 and how the professor made the comment that vitamin supplements only produce expensive urine.  My thought that followed was "Why would he make such a claim?  Was it to direct all health authority to the practitioners of health, to doctors?  Was he a spokesman for doctors?"  I didn't know.  I didn't know his credentials.  I should have checked.  But it was an Anatomy class.  He made other cracks, too, that I didn't like.  Years passed before I began to understand how universities are staffed with folks loyal to the medical industrial complex and not necessarily to human health.  This is one reason I appreciate the work of nutritional journalists, especially Bill Sardi.  
Sardi in his article, "Just Remember Dietary Supplements Are Not Supported By Science And Are A Waste of Money," reminds us, perhaps constantly so, that nutritional supplements play an important, nay, vital role in providing health, in recovering from illness and injury, as well as stave off the ravages of age-related diseases.  Troubling is the fact that we don't read as much as we should learn about the benefits, or that we begin to read regrettably when it is a bit late.  In his latest reminder, Sardi lists the benefits of certain vitamins. 
Folic Acid prevents spinal defects during birth.
In the 1990s grain products were fortified with folic acid to prevent birth defects (spina bifida, anencephaly) . . . 
Folic Acid prevents strokes; prevents deaths from stroke, and facilitates better and faster recovery.  You probably need to be on Folic Acid daily to get these results.  I wouldn't wait until after the fact if you know what I mean. 
and a decline in stroke-related mortality was reported. Researchers then subsequently reported that 31,000 stroke-associated deaths may have been prevented by folic acid food fortification. Folic acid blood levels doubled during this period (from 6.6 to 15 nanograms/milliliter per blood sample) with an accompanying 14% decline in homocysteine blood levels, which was believed to be the mechanism responsible for the decline.
If you're not familiar with Bill Sardi, a nutritional journalist who has been studying, reviewing, reporting on the supplement industry since the 1970s, and you're unsure whether to take his word, then check his sources.
Here is the Lancet:
Then in 2007 The Lancet journal reported that folic acid (vitamin B9) supplementation reduces stroke risk by 18%.
Here is the Journal of the American Medical Association:
Then again in 2015 the Journal of the American Medical Association reported the combined use of a blood pressure pill (enalapril) and folic acid, but not the drug alone, significantly reduced the risk for first stroke.
Maybe my old UC Irvine Anatomy professor could read an article or two by Bill Sardi and learn . . . learn something beyond the 3 x 5 index card of allowable opinion on vitamin supplements.  But it appears that my old Anatomy professor was not alone, that, in fact, there was an industry consensus that multivitamins were a waste of money.  Read for yourself.
Thereafter organized medicine reached a consensus that:
Dietary supplements are still popular despite little evidence they're useful. – Science-Based Medicine
Study after study has demonstrated that favorites like multivitamins don’t actually improve outcomes on a number of health measures. - VOX.com
Multivitamins are a waste of money, doctors say. – Scientific American
There is no evidence that taking a multivitamin regularly has the ability to ward off chronic diseases. – LiveScience.com
Thankfully, opinions change.  The results of Folic Acid on stroke and its effects are a stunning 73% decline.  
Fast forward to today. . . . News reports claim a massive 73% decline in strokes and stroke-related death among the highest risk patients and a 21% decline in stroke overall with folic acid supplementation.
If we're 65 and older, we should be taking Folic Acid daily.  
About 795,000 people suffer a stroke each year in the U.S. and more than 140,000 people die from stroke. Most strokes occur among adults over age 65. If a recent study holds true for every senior American, the consumption of a multivitamin with folic acid could reduce the number of strokes from 795,000 to 628,050 (166,950 fewer strokes). Stroke death rates would dramatically plunge too. And they say vitamin supplements are worthless. Go figure.
Folic Acid reduces strokes in folks with high blood pressure from 5.6% to 1.8%.  Can you doctor's prescription claim that?  Ha.
Strokes occur among individuals who have high blood pressure. Their risk for stroke is 5.6% and folic acid drastically reduces this risk to 1.8% in high-risk groups.
Imagine the savings in healthcare costs if folks supplemented daily with Folic Acid.  I didn't realize that stroke-related costs run $34 billion a year.
With strokes costing $34 billion a year, a public health agenda to encourage all senior Americans to supplement with folic acid could theoretically reduce strokes costs to $26.9 billion, a savings of $7.9 billion.
According to the Census Bureau, there were 49.2 million Americans over age 65 in 2016. At $.20 [cents] per folic acid pill, it would cost $3.59 billion for American seniors to protect themselves from a stroke. Net savings would be ~$4.3 billion. It appears modern medicine is throwing away health dollars and lives for its bias against dietary supplements. Obviously, folic acid pills far exceeded what food fortification began over two decades ago.
Folic Acid is required for DNA repair.  Blood vessels are damaged without adequate folic acid.  
The researchers noted that a low folic acid level was associated with a low blood platelet count. Folic acid is required to repair DNA. It then follows that wall of blood vessels and blood platelets are damaged and platelet count declines without adequate folic acid. Blood platelets are responsible for blood clotting, a necessary part of wound healing.

If this is true, and I have no reason so far to doubt it, why then do university professors, representatives for modern medicine, continue in their claim that vitamin supplements and multi-vitamin supplements, in particular, are of no benefit?  

Sardi addresses this too. 

HOW MODERN MEDICINE CONCLUDES DIETARY SUPPLEMENTS ARE UNNECESSARY

Here is how modern medicine comes to its erroneous conclusion [that] dietary supplements are not needed: 
. . . a good diet will provide all the nutrients necessary for health. 
Of course, that position is self-serving as modern medicine games human populations for more disease to treat.
A good diet is not enough to stave off disease or to maintain health.  And I particularly like Sardi calling out "high-calorie malnutrition."  Wow.  I wonder if one of the reasons that vitamin supplementation is frowned upon by the medical industry and its representatives at the universities is that for vitamins to be effective, one must remove sugars, high-glycemic carbohydrates, and alcohols from one's diet.  These foods are representative of huge industries.  You tell people that B1 improves this, restores that, and prevents this on condition that they stop consuming one of these foods, then you might see the conflict of interest that the university reps protect.  
Beriberi, the name for the disease that emanates from a deficiency of thiamin (vitamin B1), is broadly prevalent [in] well-fed societies as it is induced by "high-calorie malnutrition" given that added sugars, carbohydrates, alcohol, and even tea block its absorption. 
Okay, here is another bullet point for those 50 and up managing stomach acid.
The progressive decline in stomach acid secretion with advancing age is yet another reason why B1 deficiency is highly prevalent but unrecognized. 
What is interesting that B1 deficiency is not easily recognizable or detectable.  Sardi says that "it defies detection as a collective disease." And my guess is that the physician who doesn't know much about nutrition, will diagnose B1 deficiency as some psychiatric condition and compel him to write a referral to a psychiatrist rather than informally recommend a patient to take 2 B1 tablets every day for the next week, then call him by week's end.  
Derrick Lonsdale, the reigning expert on vitamin B1, says thiamin deficiency has a low mortality and a long morbidity.
That low-mortality and long-morbidity mean that a B1 deficiency won't kill you, but it will present the symptoms of illness, the kind that is chronic or "long morbidity." 
Because B1 deficiency is associated with so many maladies (autism, diabetic complications, disruptive autonomic [nervous] system disorders, heart failure, neuropathy, sudden infant death, alcoholism, it defies detection as a collective disease. An announcement of the highly absorbable fat-soluble form of vitamin B1 (Benfotiamine) cures and prevents Alzheimer's disease is expected soon. There is a doctor in Italy who is astonishingly curing Parkinson's disease with B1 shots (mostly among alcoholics).
B1 can be found aplenty in our food supply and even through supplementation.  Supply is not the issue: absorption is.  
Because of poor absorption, it is unlikely the best diet or fortified foods can overcome a state of B1 deficiency. Once classified as a prison camp for malnutrition disease, beriberi is now prevalent as a disease of overconsumption. A sub-disease population is beriberi induced by water pills (diuretics). Modern medicine can't imagine how a B vitamin deficiency prevails in a well-fed population. Vitamin B1 is well provided but just not absorbed or is rapidly excreted (diuretics).
What's terrible is that the symptoms of a B1 deficiency show up as mild cognitive, even psychiatric in nature, and so not knowing that they are deficient in B1, some folks seek relief via marijuana, which only exacerbates the symptoms.  Ugh.  
According to the US Department of Agriculture "only" 18.4% of Americans consume an inadequate amount of thiamin (that's ~57 million Americans), not enough to cause a run on health food stores, but millions more simply don't absorb or retain B1. The B1-deficient run for marijuana instead.

[BESIDES B1 & FOLIC ACID, THERE IS] ANOTHER OVERLOOKED B VITAMIN DEFICIENCY

Healthy ranges used to measure values in your blood are mistaken and often result in poor detection of B12 deficiency.  
Pernicious (vitamin B12) anemia is prevalent depending upon the blood level used to define deficiencyUp to 40% of US adults may be B12 deficient. One of the ways widespread nutritional deficiencies remain hidden is that blood tests only reveal what is called the reference range (commonly occurring range), not the healthy range. If massive numbers of people are B12 deficient then that becomes the reference range, which mistakenly can lead to the false belief an individual has a normal (common) blood level but is deficient.
Doctors misdiagnose all the time, often for self-serving interests. 
It is common for doctors to look at a blood test and mistakenly conclude whatever symptoms a patient is suffering from are not caused by a shortage of vitamin B12.
False normal B12 blood tests are common. This is likely why many older adults with so-called normal blood levels experience clearance of symptoms upon B12 supplementation.
For me at least, B12 gave me back my circadian rhythms, and I am able to return to a regular sleep pattern, one where my sleep is uninterrupted and deep; not long, just deep and I wake rested.  B12 does this.  
B12 deficiency may be rampant, especially among certain groups (vegetarians, gastric bypass patients, users of B12 depleting drugs (metformin, antacids), yet public health authorities will claim prevalence of deficiency is low. A US Department of Agriculture report issued over a decade ago noted that 4 or 10 Americans "may be flirting with vitamin B12 deficiency." 
Even milder symptoms that we dismiss with a wave of the hand could be a B12 deficiency.
Many chronic unsuspected symptoms of B12 deficiency such as a chronic cough and back pain, may never be counted in estimates of the prevalence of B12 pathology.
The comparative costs of supplementation are in your favor. 
JUST REMEMBER, the prevailing position by modern medicine, despite the science, is that vitamin supplements are needless. You must be a crazy, eccentric, ignorant, easily misled fool to be caught taking dietary supplements. Best to take them in your closet where nobody will see you. Because of this attitude, many patients simply hide the fact from their doctors [that] they are loading up with vitamins every day. Still, Americans only spend ~$8 a month on dietary supplements and ~$250 a month on drugs. It should be the other way around.

Tuesday, April 3, 2018

METHYLCOBALAMIN, B-12, SLOWS BRAIN SHRINKAGE & RESTORES YOUR CIRCADIAN RHYTHMS

George Hoyt Whipple discovered B-12 in 1934.  So knowledge of this nutritional compound is well known and well-studied.  B-12 is water soluble, plays a key role in the normal functioning of the brain and nervous system, and basically interacts with the bacteria in your body to produce energy, described here:
Vitamin B12, also called cobalamin, is a water-soluble vitamin that has a key role in the normal functioning of the brain and nervous system via the synthesis of myelin (myelinogenesis),[1][2] and the formation of red blood cells. It is one of eight B vitamins. It is involved in the metabolism of every cell of the human body, especially affecting DNA synthesis, fatty acid and amino acidmetabolism.[3] No fungi, plants, or animals (including humans) are capable of producing vitamin B12. Only bacteria and archaea have the enzymes needed for its synthesis. Some substantial sources of B12 include animal products (shellfish, meat), fortified foods, and dietary supplements.[4][5] B12 is the largest and most structurally complicated vitamin and is produced industrially only through bacterial fermentation. This B12 is used for fortified foods and supplements. It has also been produced synthetically via vitamin B12total synthesis.
Yeah, the synthetic version of B-12, called cyanocobalamin, actually has cyanide in it.  You may want to steer clear of that one.  Methylcobabalmin is the preferred for of B-12.

Sardi published an article back on September 11, 2013, titled "The Incredible Shrinking (Mushy) Vitamin B-12 Deficient Brain."  It will alert you to the serious problems that result from a B-12 deficiency, and I say this as a guy who takes a supplement daily (with a B-12 dose of 320mcg; that exceeds a maintenance dose by 5000%.  I wonder what a therapeutic dose is).  His article starts with a citation to the Tufts University study on how a mild deficiency of B-12 speeds dementia.  Yikes.  In terms of numbers, what is a deficiency of B-12?  


Magnetic resonance imaging (MRI) scans of the brain of a 76-year-old patient with dementia. The brain has shrunk, and the ventricles, the fluid-filled spaces (dark brown) at the center of the brain, have become enlarged. Photo: BSIP/Photoresearchers Inc.
It's elusive.  According to the B-12 website (yes, there's a website dedicated just to vitamin B-12), he states that it is 7ug, whatever that is.  But there is a summary to the article, and that's here:
The daily requirement according to DGE: 3 µg.  
The daily requirement is not actually the necessary amount!
Current studies recommend an intake of 7-10 µg.
During stress, illness and pregnancy, a higher intake is required.
Vegans should take supplements. 
Okay, so it looks like you want to be maintaining, meaning taking on a daily basis, 3 µg So anything less than that, you risk becoming deficient and moving toward mild dementia.  So don't start down that road.  It's a lot easier to remember to take the methylcobalamin, B-12, than to try to rebuild the brain.  
Investigators at Tufts University display striking images of the human brain when it is deficient in vitamin B-12.  Brain scans show fluid-filled spaces as the center of a shrinking B-12 deficient brain—literally holes in the brain. 
The report starts
Being even mildly deficient in vitamin B-12 may put older adults at a greater risk for accelerated cognitive decline, an observational study from the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts suggests.  
Still, no numbers on how to measure "Being even mildly deficient . . . ."  
BENEFITS OF B-12, METHYLCOBALAMIN

BENEFIT #1:  Delays and significantly slows the shrinkage of the brain.  Methylcobalamin, B-12 produces stunning benefits on the brain, on the heart, on the spine, and the muscles and nerves that run all through your body.  It slows brain shrinkage by 7 times of what is normal.  This should be a daily regimen for life.   
A prior study showed that high-dose B vitamins (800 mcg folic acid, 20mgs vitamin B6, 500 mcgs of B-12) slows the rate of shrinkage in the human brain, and more demonstrably (by 7 times) shrinkage of grey matter in the brain.
So here I've listed some of the benefits of B-12: Methyllcobalamin, B-12, Betaine Hydrochloride, and Benfotiamine.  But what causes brain shrinkage in the first place?  Is there a way to prevent shrinkage or avoid it altogether?  First, I would stay away from foods drain the B-12 stores from your body, things like coffee, alcohol, digestive disorders, pernicious anemia, injuries, and worst of all, stress.  Stress is a killer, especially chronic stress.  B-12 helps fight off the damaging effects of stress on the brain.  

BENEFIT #2:  B-12 revitalizes and restores brain, heart, and spinal energy.  Few things do all three.

BENEFIT #3:  B-12 restores your circadian rhythmsYou will get the best sleep of your life.  Nothing compares.  Plus, given all the other benefits of how it rebuilds the brain, spine, heart, blood vessels, tell me, what's not to like.  If your sleep is better, just think how less irritable you'll be the next day.  I got the best sleep I'd head in decades.   
Effects of vitamin B12 on performance and circadian rhythm in normal subjects.  Neuropsychopharmacology, 1996.
This preliminary study investigates effects of methyl- and cyanocobalamin on circadian rhythms, well-being, alertness, and concentration in healthy subjects. Six women (mean age 35 years) and 14 men (mean age 37 years) were randomly assigned to treatment for 14 days with 3 mg cyano-(CB12) or methylcobalamin (MB12) after 9 days of pre-treatment observation. Levels in the CB12 group increased rapidly in the first, then slowly in the second treatment week, whereas increase in the MB12 group was linear. Urinary aMT6s excretion was reduced by both forms of vitamin B12 over 24 hours with a significant decrease between 0700-1100 hours, whereas urinary excretion of potassium was significantly increased between 0700-1100 hours. Activity from 2300-0700 hours increased significantly under both forms of vitamin B12. Sleep time was significantly reduced under MB12 intake. In this group the change in the visual analogue scales items "sleep quality," "concentration," and "feeling refreshed" between pretreatment and the first week of treatment showed significant correlations with vitamin B12 plasma levels. Cortisol excretion and temperature were not affected by either medication. We conclude that vitamin B12 exerts a direct influence on melatonin. Only MB12 has a positive psychotropic alerting effect with a distribution of the sleep-wake cycle toward sleep reduction.

WHAT B12 DEFICIENCY LOOKS LIKE
You already know what it looks like: fatigue because your circadian rhythms are ruined; poor appetite because you're eating fast food and coffee because you're trying to compensate for the deleterious disruption of your circadian rhythms.  Get the B-12.  Depression and numbness and tingling in the hands and or feet all for the same reason: disruption of your circadian rhythms that are built on your body's ability to coordinate its nerve and muscle and hormone functions properly.  You don't want to let these conditions go unanswered.  Get the B-12.  Take it throughout the day.  Take it daily.  It's at this point that most medical articles will say "so speak to your doctor promptly about treatment," but I would say, hey, your doctor doesn't know much about nutrition and even less about nutritional supplements, so instead of speaking with your doctor, consult the valuable articles and books by Bill Sardi.  

CAUSES OF B-12 DEFICIENCY
Bill Sardi points to two causes of B-12 deficiency: lack of absorption and H. Pylori bacterium.  The latter shuts down stomach acid and the former   
Lack of absorption of dietary and supplemental vitamin B-12 due to progressive inability to produce stomach acid is cited as a growing concern.  Therefore, it may be that widespread H. Pylori infection, which is prevalents in more than half of the US population, could be a parallel facto as H. Pylori shuts down production of stomach acid or hydrochloric acid. 
Lack of absorption is a serious problem for oldsters.  We might eat right but we're just not absorbing the nutrition that we need from a healthy diet.  
The academy estimates that between 10 percent and 30 percent of people older than 50 produce too little stomach acid to release B12 from its carrier protein in foods, and as the years advance, the percentage of low-acid producers rises.
Diabetics are at an added risk.
Another concern is that most often used anti-diabetic drug, metformin, depletes the body of vitamin B-12.  Metformin use has been associated with decliningmental function.

REMEDY THE DEFICIENCY

1.  Eat lean animal meats to get B-12 from food. 

Animal proteins, such as lean meats, poultry and eggs, are good sources of vitamin B-12. Because older adults may have a hard time absorbing vitamin B-12 from food, the USDAʼs 2010 Dietary Guidelines for Americans recommend that people over age 50 incorporate foods fortified with B-12 or supplements in their diets.
2.  Supplement with Betaine Hydrochloride to replenish stomach acid so that you can digest the foods above and get the needed B-12.  

The group studied did eat meats, so one of the reasons for them being deficient is due to low stomach acid at age 75 and above.  To remedy the problem of low stomach acid, then you'll need to supplement with Betaine Hydrochloride.  For low stomach acid, Sardi recommends the following:  
1) Follow an anti-H Pylori regimen;
2) Supplement your diet with zinc which is needed to make hydrochloric acid in the stomach. [I never heard of this before];
3) Take Betaine Hydrochloride with meals to provide supplemental acid source. 

SUPPLEMENTS TO REMEDY NERVE & MUSCLE FATIGUE, A TIRED HEART, A TIRED BRAIN, AND A TIRED SPINE

Methylcobalamin
 

If you're not getting enough B12 from the meats and eggs in your diet, supplement with this hydrochloric acid to help break down those proteins and other nutrients, like B-12

Betaine Hydrochloride.  


Mind Boosters: A Guide to Natural Supplements That Enhance Your Mind, Memory, and Mood, Ray Sahelian, 2000.