A warning about NAC for those who have emphysema or COPD

A warning about NAC for those who have emphysema or COPD. https://t.co/dyEiCxmWVJ

— DCGreenZone1 (@DCGreenZone) July 6, 2022

Lung adenocarcinoma development in NAC-treated mice.

Lung tissue histology in aged NAC-treated animals revealed the formation of tumors exhibiting lung adenocarcinoma characteristics in 50% of JunD–/– mice and in 10% of controls (Figure 4, A and B). The appearance of the tumors was typical of adenocarcinoma with conspicuous papillary structures associated with a collagen network that stained with Sirius Red, as reported in previous studies (Figure 4, C and D, and ref. 15). Adenocarcinoma tissue sections were also characterized by high counts of Ki67-positive cells compared with nonadenocarcinoma tissue (Figure 4E). In contrast, p21 and p16 staining activities were not detected in adenocarcinoma tissue (Figure 4F). No such tumors were detected in vehicle-treated JunD–/– or control mice, even when studied until 24 months of age. No animals in any group had tumors detected in the liver, spleen, or kidneys. Moreover, in situ studies detected no associated lesions in mice with lung cancer. Inflammatory infiltrates were detected in the lungs of most of the aged mice (Figure 4G) and were more marked in the aged JunD–/– mice than in their controls but were not affected by NAC treatment (Figure 4G). These changes were not related to alterations in lung levels of mucin (16), which did not differ between aged and young mice and which was not affected by JunD  inactivation (Supplemental Figure 2).

Definitely interesting and well-worth a conscious pause in the use of NAC.  Other antioxidants are available that seemingly have no increased risk of tumor growth.  

Cell senescence is known to inhibit cell transformation and tumor initiation. We consequently hypothesized that NAC treatment promoted tumor initiation by inducing escape from cell senescence (17, 18). Interestingly, p16- and p21-stained cells, although sparsely distributed in lungs from NAC-treated mice, were not seen within tumors (Figure 4F). In contrast, Ki67-stained cells were seen only within tumors (Figure 4B). JunD–/–-derived mouse embryonic fibroblasts (MEFs) display p53-dependent premature senescence (19), and NAC treatment decreases p53 levels in the context of lung tumor progression in mice (8). Accordingly, we found decreased lung p53 protein and p16 mRNA levels in NAC-treated aged mice (Supplemental Figures 3 and 4), supporting the concept that NAC limits the expression of key senescence effectors and tumor suppressor genes

 

CINNAMON: AN EXCELLENT ANTI-BIOFILM FOR BRUSHING YOUR TEETH

Personally, I am not a fan of the xylitol gums or breath mints, because I don't do well with hardly any sugar forms except for sugar.  But since I don't want sugar either, I prefer the natural anti-biofilms that he lists:  Rosemary, Clove, Thyme, Garlic, Curcumin, Oregano, Cinnamon, and NAC.  In fact, over the years, many folks used baking soda as an abrasive to scrub the teeth of plaque and biofilms.  But the abrasive that I like is cinnamon, for not only does it clean the surface of the teeth, it also has lots of antibiotic properties that seep into the tiny cracks in your teeth and into the narrow fissures of your gums, and jaw and has a wonderful effect on the tiny blood vessels in your mouth.  For me, it has an invigorating effect.  Check out the benefits of brushing with cinnamon.    

NAC causes microvascular collapse in cancerous tumor core to eliminate tumors in in vitro and in vivo studies

As cancer cure and chemopreventive, NAC causes microvascular collapse in cancerous tumor core to eliminate tumors in in vitro and in vivo studies. pic.twitter.com/BQvHfd0Rv3

— Dr. Hachi (@DrHachi3) March 13, 2022

This is good news.  Find the NAC from Swanson here. 

TO MAKE VITAMIN D THERAPY SUCCESSFUL, YOU NEED TO HAVE ADEQUATE GLUTATHIONE IN YOUR BLOOD

I will do an epic thread as to why I am not in favour of vitamin D supplementation currently but meanwhile please note this

"Vit D supplements widely consumed by the public are unlikely to be successful unless the glutathione status is also corrected". https://t.co/3IFkRPd1Bz

— Magnesium Girl - Yin solutions in a yang world (@LocalRachel) January 31, 2022

This was interesting because everyone is under the assumption that vitamin D is a near-cure-all.  Don't get wrong.  Vitamin D all by itself has saved me from two seriously stressed occasions at work. So as a fortifying compound, I take 8,000 IU of vitamin D every day.  But all by itself, D has its limits in treating some of the more serious conditions.  Yes, you need magnesium to improve its absorption.  But it looks Glutathione is the key ingredient if you want to enjoy all the benefits of D.

The improvement in GSH [glutathione] status that results from co-supplementation with VD [vitamin D] and l-cysteine [NAC, pick it up from one of these distributors] (LC; a GSH precursor) significantly reduced oxidative stress in a mouse model of 25(OH)VD deficiency. It also positively upregulated VD regulatory genes (VDBP/VD-25-hydroxylase/VDR) in the liver and glucose metabolism genes (PGC-1α/VDR/GLUT-4) in muscle, boosted 25(OH)VD, and reduced inflammation and insulin resistance (IR) levels in the blood compared with supplementation with VD alone. In vitro GSH deficiency caused increased oxidative stress and downregulation of VDBP/VD-25-hydroxylase/VDR and upregulation of CYP24a1 in hepatocytes and downregulation of PGC-1α/VDR/GLUT-4 in myotubes. This study demonstrates that improvement in the GSH status exerts beneficial effects on the blood levels of 25(OH)VD, as well as on the inflammation and IR in a VD-deficient mouse model. Thus, the VD supplements widely consumed by the public are unlikely to be successful unless the GSH status is also corrected.