TO MAKE VITAMIN D THERAPY SUCCESSFUL, YOU NEED TO HAVE ADEQUATE GLUTATHIONE IN YOUR BLOOD

I will do an epic thread as to why I am not in favour of vitamin D supplementation currently but meanwhile please note this

"Vit D supplements widely consumed by the public are unlikely to be successful unless the glutathione status is also corrected". https://t.co/3IFkRPd1Bz

— Magnesium Girl - Yin solutions in a yang world (@LocalRachel) January 31, 2022

This was interesting because everyone is under the assumption that vitamin D is a near-cure-all.  Don't get wrong.  Vitamin D all by itself has saved me from two seriously stressed occasions at work. So as a fortifying compound, I take 8,000 IU of vitamin D every day.  But all by itself, D has its limits in treating some of the more serious conditions.  Yes, you need magnesium to improve its absorption.  But it looks Glutathione is the key ingredient if you want to enjoy all the benefits of D.

The improvement in GSH [glutathione] status that results from co-supplementation with VD [vitamin D] and l-cysteine [NAC, pick it up from one of these distributors] (LC; a GSH precursor) significantly reduced oxidative stress in a mouse model of 25(OH)VD deficiency. It also positively upregulated VD regulatory genes (VDBP/VD-25-hydroxylase/VDR) in the liver and glucose metabolism genes (PGC-1α/VDR/GLUT-4) in muscle, boosted 25(OH)VD, and reduced inflammation and insulin resistance (IR) levels in the blood compared with supplementation with VD alone. In vitro GSH deficiency caused increased oxidative stress and downregulation of VDBP/VD-25-hydroxylase/VDR and upregulation of CYP24a1 in hepatocytes and downregulation of PGC-1α/VDR/GLUT-4 in myotubes. This study demonstrates that improvement in the GSH status exerts beneficial effects on the blood levels of 25(OH)VD, as well as on the inflammation and IR in a VD-deficient mouse model. Thus, the VD supplements widely consumed by the public are unlikely to be successful unless the GSH status is also corrected.