Saturday, January 8, 2022

PHOTOS [CAREFUL]: Genital necrosis with cutaneous thrombosis after COVID-19 mRNA vaccination

An 84-year-old Japanese woman presented to our department with a three-day history of genital necrosis. She had received her first dose of Pfizer–BioNTech (New York, NY, USA; Mainz, Germany) BNT162b2 mRNA COVID-19 vaccine 26 days before admission. Nine days after the vaccination, she developed increasing pain in her genital region. She denied any trauma or precipitating event. Her medical history was significant for deep vein thrombosis after orthopaedic surgery, for which she had been receiving edoxaban over the past three years. She had no other risk factors for thrombosis.

Treatment was started with ampicillin/sulbactam along with local wound care. Her fever, leukocytosis and genital pain resolved within the first week. The skin lesions also improved: more than 80% of the eschar had fallen off when she was discharged after one month of admission (Fig.2a), and epithelization was almost completed another month later (Fig.2b).

 

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