HUSTLEBITCH: She calls it the Cellular Barrier Permeability Theory - not a diagnosis, not advice - but a framework that explains why so many people are sick yet told “nothing’s wrong” while their lives fall apart. The carnivore diet is great at repairing cellular membranes.

🚨 THIS DOCTOR ADMITS SHE’S BEEN QUIETLY TRACKING 100,000+ PATIENTS - AND SAYS MEDICINE IS MISDIAGNOSING MILLIONS

“I am so nervous to make this video.”

For 2+ YEARS, an American orthopedic surgeon known online as “The Little Misdiagnosed” quietly collected 100,000+ patient… pic.twitter.com/S66MWbLBdQ

— HustleBitch (@HustleBitch_) January 7, 2026

THIS DOCTOR ADMITS SHE’S BEEN QUIETLY TRACKING 100,000+ PATIENTS - AND SAYS MEDICINE IS MISDIAGNOSING MILLIONS “I am so nervous to make this video.” For 2+ YEARS, an American orthopedic surgeon known online as “The Little Misdiagnosed” quietly collected 100,000+ patient stories from people diagnosed with Ehlers-Danlos, POTS, MCAS, dysautonomia, endometriosis, brain fog, GI disorders - different labels, same complaints, same “normal” labs. Her claim: • The problem is NOT damaged organs. • It’s leaky barrier systems triggering nonstop immune alarms. • A body locked in survival mode while medicine treats symptoms in silos - a body-wide signaling meltdown sliced into pieces instead of treated as a system. She calls it the Cellular Barrier Permeability Theory - not a diagnosis, not advice - but a framework that explains why so many people are sick yet told “nothing’s wrong” while their lives fall apart.

If specialists keep treating pieces and no one treats the system… how many people were dismissed because the explanation didn’t exist yet? 

SAMA HOOLE: What actually heals your gut lining? Glycine from collagen, Proline from collagen, Glutamine from meat, Vitamin A from animal fat, Vitamin D from animal fat, Butyrate produced when you're fat-adapted

What actually heals your gut lining:

- Glycine (from collagen)
- Proline (from collagen)
- Glutamine (from meat)
- Vitamin A (from animal fat)
- Vitamin D (from animal fat)
- Butyrate (produced when you're fat-adapted)

What irritates your gut lining:

- Fiber (mechanical…

— Sama Hoole (@SamaHoole) November 1, 2025

What actually heals your gut lining: - Glycine (from collagen) - Proline (from collagen) - Glutamine (from meat) - Vitamin A (from animal fat) - Vitamin D (from animal fat) - Butyrate (produced when you're fat-adapted) What irritates your gut lining: - Fiber (mechanical irritation) - Lectins (creates permeability) - Phytates (inflammation)

Doctors recommend the second list. 

SAMA HOOLE: Your body is approximately 30% collagen by protein weight. Fiber makes up 0% of your body.

Your body is approximately 30% collagen by protein weight.

Collagen makes up:

Skin (70% collagen)
Tendons (85% collagen)
Ligaments (90% collagen)
Bones (30% collagen)
Blood vessels (collagen structure)
Gut lining (collagen framework)

Fiber makes up: 0% of your body.

Yet…

— Sama Hoole (@SamaHoole) December 1, 2025

SAMA HOOLE: The reason you'll feel fuller on ground beef or brisket compared to ribeye, is because of the higher collagen content.

The reason you'll feel fuller on ground beef or brisket compared to ribeye, is because of the higher collagen content.

The tougher the cut, the higher the collagen.

And collagen stimulates GLP-1, which basically makes it nature's ozempic.

Hunger is getting nuked.

— Sama Hoole (@SamaHoole) July 13, 2025

Collagen isn’t classed as essential, but it might as well be. It doesn’t just help your skin, hair, and nails. There are a vast array of perks that span the entire metabolism.  https://t.co/YDyvyzIKXv

— Sama Hoole (@SamaHoole) June 7, 2025

No lab can match what a cow does:

– Converts cellulose to collagen
– Omega-6 to saturated fat
– Grass to testosterone fuel
– Sunlight and rain into steak and cream
– Crop waste into nutrient-dense food
– Inedible scrubland into life-sustaining protein

If cows didn't exist, we'd… pic.twitter.com/KfpMeTXvwp

— Sama Hoole (@SamaHoole) August 30, 2025

CONSPIRACY GARDNER: Thin layer [of the eggshell membrane] is loaded with collagen, amino acids, and compounds that help rebuild joints, strengthen the gut lining, and support overall…

Don’t waste those membranes!

Most people toss out the eggshell membrane without even realizing it is packed with powerful nutrients. This thin layer is loaded with collagen, amino acids, and compounds that help rebuild joints, strengthen the gut lining, and support overall… pic.twitter.com/bBZ24AFHDA

— Conspiracy Gardener Homestead (@DaysofNoahGen6) June 7, 2025

Mutations on the COL6A6 gene, which is responsible for the synthesis of collagen, correlate very strongly with eczema. Collagen helps to hydrate and provide relief for eczema

Collagen is good for hydrating the skin.  But Eczema has no cure.  The best you can hope for is to manage the flareups. 

From National Eczema,

Collagen is a naturally occurring protein in the human body that makes up around 75% of our skin. According to Dr. Shari Marchbein, a board-certified dermatologist in New York City, “collagen is the main structural protein that forms the connective tissue throughout our body, from skin to bones, muscles, tendons, and ligaments.” Within our skin, collagen also helps maintain hydration – a critical concern for people with eczema, as prolonged dehydration of the skin can lead to cracks and fissures. Skin dehydration is one of the causes of skin barrier dysfunction in people with eczema and may increase the risk of Staph infection

from Dr. Harlan, 

Collagen synthesis is clearly an important part of the skin’s health. But can this “glue-producing” protein really help eczema?

In a word, yes. Collagen is an important part of your skin’s barrier function. Inadequate collagen synthesis can lead to problems ranging from dryness to poor healing. Mutations on the COL6A6 gene, which is responsible for the synthesis of collagen, correlate very strongly with eczema.  

Adding that, 

A 2017 study led by the Japanese Institute for Investigative Dermatology found that eczema patients taking collagen tripeptides had lower blood levels of inflammatory cytokines and chemokines than eczema patients who did not supplement. While the study didn’t definitively prove that collagen supplements help eczema flares, it suggests that they could, if given within the right parameters. 

Sounds good on paper,

In 2022, a Canadian study found that marine collagen, which is taken from fish, jellyfish, and sponges, contributed to improved skin barrier function and faster healing of the skin. The reason for this seems to be that this kind of collagen stimulates the migration of fibroblasts. We already know that fibroblasts play a key role in collagen synthesis; they also act as “flying squads,” migrating from their source to deal with damaged tissues. This migration is inhibited in eczema-prone skin. Marine collagen seems to enhance the dermal fibroblasts’ ability to migrate from the dermis to other layers of the skin as needed during eczema flares. 

This could be the difference, 

The study’s authors note that marine collagen peptides have a smaller molecular weight than most traditional bovine collagen supplements. This means that they are more easily absorbed by the body’s tissues. 

Collagen is the primary building block of your body’s skin, muscles, bones, tendons and ligaments, and other connective tissues. It’s also found in your organs, blood vessels, and intestinal lining.

Great Lakes hydrolyzed collagen has been my go to with some salt and vitamin C.

— Nevyn (@Nevyn05217348) July 3, 2023

Collagen is important for a youthful look.  A good red meat diet is essential but adding collagen as we age is important too for function and appearance. 

WHAT IS COLLAGEN?

Collagen is the most abundant protein in your body. It accounts for about 30% of your body’s total protein. Collagen is the primary building block of your body’s skin, muscles, bones, tendons and ligaments, and other connective tissues. It’s also found in your organs, blood vessels, and intestinal lining.

Proteins are made from amino acids. The main amino acids that make collagen are proline, glycine and hydroxyproline. These amino acids group together to form protein fibrils in a triple helix structure. Your body also needs the proper amount of vitamin C, zinc, copper and manganese to make the triple helix. 

Collagen More Important Than Calcium for Building Bone

Dr.Kaayla Daniel says "Our bones need the structure of collagen fibers. So it's the structure that's most important.  And the calcium gets laid on that.  The collagen framework is what's most important."  Eat plenty of stews, broths, and mint tea she adds.