Wednesday, March 29, 2023

Ivermectin clears out those insta-senescent cells!

From NCBI

defective apoptosis [cell death] contributes to both tumorigenesis [tumor generating] and chemoresistance [13].

EFFECTS OF AUTOPHAGY ON CELL GROWTH ABILITY 

To confirm the anticancer effects of autophagy on glioma cells, MTT assay and colony formation analyses were conducted to assess the growth viability of glioma cells. We evaluated the combined effects of IVM and CQ on cell proliferation using U251 and C6 cells. As shown in Figure 4A, IVM co-treatment with CQ decreased the cell growth ability in U251 and C6 cell cells, and notably CQ exhibited a lesser effect on glioma cells. As shown in Figure 4B, we found that IVM co-treatment with CQ significantly inhibited colony formation and induced significant decrease in the colony formation ratio. These results indicated that autophagy increased cell growth ability in U251 and C6 cells.

Autophagy is the destruction of damaged or redundant cellular components occurring in vacuoles within the cell

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