Saturday, June 14, 2025

Polysorbate 80, what is it good for? Absolutely nothing except for dysbiosis, leaky gut, and other gut ailments


Polysorbate 80, a common emulsifier in food, cosmetics, and pharmaceuticals, is generally recognized as safe by regulatory agencies like the FDA and EFSA when used within approved limits. However, some studies and concerns suggest potential adverse effects on human biology, particularly at high doses or with chronic exposure. Below is a summary of the potential harms based on available evidence: GUT HEALTH DISRUPTION Mechanism: Polysorbate 80 may alter the gut microbiota and compromise the intestinal barrier. Studies in mice (e.g., Chassaing et al., 2015) showed that it promoted inflammation and dysbiosis, contributing to conditions like colitis and metabolic syndrome.

Human Relevance: While human studies are limited, these findings raise concerns about chronic consumption, especially in individuals with pre-existing gut issues like inflammatory bowel disease (IBD). It may increase intestinal permeability ("leaky gut"), potentially allowing harmful substances to enter the bloodstream. Immune System Effects Inflammation : Polysorbate 80 has been linked to low-grade systemic inflammation in animal models, which could exacerbate chronic diseases in humans, such as obesity or cardiovascular conditions. 

: Rare cases of hypersensitivity or anaphylactic reactions have been reported, particularly in intravenous medications containing polysorbate 80 (e.g., in some vaccines or chemotherapy drugs). Potential Carcinogenicity Concerns Contamination Risk : Polysorbate 80 can contain trace amounts of ethylene oxide or 1,4-dioxane, both classified as potential carcinogens. Regulatory bodies set strict limits to minimize this risk, but long-term exposure to low levels remains under scrutiny. Animal Studies : High doses in rodent studies have shown no direct carcinogenic effects, but the data is not conclusive for humans. Hormonal Effects : Some in vitro studies suggest polysorbate 80 may interfere with estrogen signaling or other hormonal pathways, potentially acting as an endocrine disruptor. However, human evidence is sparse and inconclusive. Reproductive Health : Animal studies at high doses have indicated possible effects on ovarian function or fertility, but these findings are not directly applicable to typical human exposure levels. Metabolic and Cardiovascular Impact
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Metabolic Syndrome : As mentioned, animal studies link polysorbate 80 to metabolic disturbances, including obesity and insulin resistance, possibly via gut microbiota changes. Cardiovascular Risk : By promoting inflammation or altering lipid metabolism, chronic exposure might indirectly contribute to cardiovascular issues, though direct evidence in humans is lacking. Toxicity at High Doses : At very high doses (far exceeding typical dietary or pharmaceutical exposure), polysorbate 80 can cause gastrointestinal distress, kidney damage, or hemolysis (red blood cell destruction) in animal studies. Human Exposure : Normal consumption levels (e.g., in processed foods like ice cream or salad dressings) are well below these thresholds, with an acceptable daily intake (ADI) set at 25 mg/kg body weight by the WHO. Key Considerations

Dose-Dependent Effects: Most adverse effects are observed at high doses in animal studies, which may not reflect typical human exposure through food or cosmetics: People with compromised gut health, allergies, or chronic inflammatory conditions may be more susceptible to potential harms.
Regulatory Oversight: Agencies like the FDA and EFSA have deemed polysorbate 80 safe within specified limits, but critics argue that cumulative exposure from multiple sources (food, drugs, cosmetics) is understudied.
Limited Human Data: Much of the concern stems from animal or in vitro studies, with few large-scale, long-term human studies available.
Conclusion:
Polysorbate 80 is likely safe for most people at regulated levels, but excessive or chronic exposure may pose risks, particularly to gut health, immune function, and metabolic processes. Those with specific health conditions or concerns about additives may benefit from minimizing consumption of processed foods or products containing polysorbate 80. For personalized advice, consulting a healthcare provider is recommended.
If you’d like me to analyze specific studies, X posts, or web sources for more context, let me know!
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 From Killing Cancer Cells to Calming Alzheimer’s: Is Cannabis the Next Medical Miracle?

1. Anti-Cancer Properties of CBD: Osteosarcoma (Bone Cancer): CBD demonstrates multi-faceted anti-cancer effects against osteosarcoma cells in laboratory settings and animal models.
"CBD slowed down the growth and spread of osteosarcoma cells in lab tests." "CBD increased cell death (apoptosis) in osteosarcoma cells and affected proteins related to cell death." "In mice with osteosarcoma, CBD slowed tumor growth and increased cancer cell death." "CBD prevented osteosarcoma cells from moving or spreading." Oral Cancer: Strong evidence suggests CBD's effectiveness in inhibiting and eradicating oral cancer cells. "CBD can slow or stop oral cancer cell growth by damaging their DNA." "Stronger doses (25 µM or higher) were very effective at killing cancer cells, and effects got stronger over time." The source suggests "CBD might be a new way to treat oral cancer." 2. Efficacy in Neurological Disorders: Drug-Resistant Epilepsy (DRE): Cannabis oil, particularly a mix of CBD and THC, has shown remarkable success in achieving seizure freedom in DRE patients. "19 patients with DRE... achieved SF (seizure free): 15 kids and 4 adults." "On average, patients were seizure-free for about 245 days, often in stretches of at least 90 days." "Five patients stayed seizure-free for a year or more." Crucially, "Three patients were able to stop all other epilepsy medicines." Additionally, many patients experienced "at least 50% fewer seizures," with reductions continuing over time. Most seizure types improved, with complex motor seizures being an exception. Parkinson's Disease (PD): A survey in France indicates significant patient-reported benefits for common PD symptoms. "Many PD patients in France find cannabis and CBD helpful, especially for sleep, pain, and stiffness." The need for improved communication between doctors and patients and safer legal access is highlighted. Alzheimer's Agitation: A cannabis-based spray (nabiximols/Sativex) appears to be a safe and practical option for managing agitation in Alzheimer's patients. "The spray was safe—no side effects or safety issues were reported." "The results show nabiximols (Sativex) is practical and safe to use for AD patients with agitation." 3. Mental Health and Quality of Life Improvements: Obsessive-Compulsive Disorder (OCD): A new study indicates that medical cannabis can significantly enhance quality of life for OCD patients. "New study shows BIG improvements in quality of life, mood, and sleep!" Specific improvements noted include "General health," "Mood and depression," "Sleep," and "Anxiety." 4. Increasing Adoption Among Seniors with Chronic Conditions: Growing Use: Cannabis use among US seniors has nearly doubled in two years, largely driven by its perceived benefits for chronic illnesses. "The most dramatic increase came from people with chronic obstructive pulmonary disease (COPD), whose usage doubled from 6.4% to 13.5%." "People with chronic conditions like cancer, diabetes, heart disease, and high blood pressure also reported using cannabis more." "And those dealing with two or more chronic illnesses saw use rise from 3.5% to 8.2%." The bulletin posits that while greater availability plays a role, the "real reason" for this increase is the perceived therapeutic value for managing chronic conditions. Conclusion and Implications: The presented sources strongly suggest that cannabis, particularly CBD, is emerging as a versatile therapeutic agent with significant potential across multiple medical domains. Its demonstrated anti-proliferative and pro-apoptotic effects in various cancer types, its ability to dramatically reduce seizures in drug-resistant epilepsy, and its reported benefits for symptoms of Parkinson's, Alzheimer's agitation, and OCD highlight a broad spectrum of applications. The increasing self-reported use among seniors with chronic conditions further underscores a growing patient-led recognition of its efficacy. However, the recurring theme of the need for better communication between healthcare providers and patients, alongside safe and legal access, indicates that while the science is advancing rapidly, regulatory and clinical integration still require significant development. These findings reinforce the notion that cannabis could indeed be "the next medical miracle," necessitating continued research and thoughtful policy development.
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MINNESOTA: Rep. Melissa Hortman & her husband have died. God rest their souls.

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Friday, June 13, 2025

CAMUS: Bifidobacteria are powerhouse probiotics linked to stronger immunity, better digestion, and reduced inflammation.

While treating patients and protecting herself with megadoses of Vitamin C, Dr. Hazan’s routine stool sample analysis revealed something extraordinary: her bifidobacteria levels—a key marker of gut health—had skyrocketed fourfold

Dr. Sabine Hazan has uncovered a stunning link between high-dose Vitamin C and gut microbiome health. While treating patients and protecting herself with megadoses of Vitamin C, Dr. Hazan’s routine stool sample analysis revealed something extraordinary: her bifidobacteria levels—a key marker of gut health—had skyrocketed fourfold! Her scientist colleague urged her to investigate further. Without hesitation, Dr. Hazan pivoted her research, collaborating with naturopaths to collect and analyze stool samples from patients before and after Vitamin C supplementation. The results? Across 20-25 samples, high-dose Vitamin C consistently boosted bifidobacteria levels. This wasn’t just a fluke—it was a game-changer. Dr. Hazan’s team published a peer-reviewed paper confirming that Vitamin C increases bifidobacteria not only in patients but also in vitro. This discovery could reshape how we approach gut health, immunity, and even chronic disease prevention. Why does this matter? Bifidobacteria are powerhouse probiotics linked to stronger immunity, better digestion, and reduced inflammation. Dr. Hazan’s work suggests that a simple, accessible nutrient like Vitamin C could be a key to unlocking a healthier microbiome—especially in high-risk or severe illness cases. This is science in action: bold, curious, and transformative. Kudos to Dr. Hazan for following the data and challenging conventional wisdom. Let’s keep pushing for research that empowers health naturally!
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DR. ERIC BERG: Correct atrophied eye lens by walking outside for 45 minutes and just looking at the birds, the trees, the clouds, plants, animal life.

Correct atrophied eye lens by walking outside for 45 minutes and just looking at the birds, the trees, the clouds, plants, animal life.  This flexes your lens and relaxes it so that it can reverse the atrophy on the lens. 

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