SAMA HOOLE: Ketones cross the blood-brain barrier more easily than glucose. This is not accidental. Evolution designed the brain to preferentially access ketones during fasting or low-carb states. Why? Because ketones are the premium fuel for neurons.

Ketones cross the blood-brain barrier more easily than glucose.

This is not accidental.

Evolution designed the brain to preferentially access ketones during fasting or low-carb states.

Why? Because ketones are the premium fuel for neurons.

They produce 25% more ATP per oxygen…

— Sama Hoole (@SamaHoole) November 9, 2025

Ketones cross the blood-brain barrier more easily than glucose. This is not accidental. Evolution designed the brain to preferentially access ketones during fasting or low-carb states. Why? Because ketones are the premium fuel for neurons. They produce 25% more ATP per oxygen molecule than glucose. They generate fewer reactive oxygen species (less oxidative stress). They stabilise neuronal membranes and reduce seizure activity. Your brain runs better on ketones. This is measurable, repeatable, documented neuroscience.

SAMA HOOLE: "I'm vegan for the environment!" Almonds require 15,000 liters per kg, destroying California's water table. This is why vegans are ecologically illiterate.

"I'm vegan for the environment!"

Avocados: require 320 liters of water per kg, grown in drought regions.

Almonds: require 15,000 liters per kg, destroying California's water table.

Quinoa: environmental destruction in South America, local food crisis.

Soy: monoculture…

— Sama Hoole (@SamaHoole) November 9, 2025

"I'm vegan for the environment!" Avocados: require 320 liters of water per kg, grown in drought regions. Almonds: require 15,000 liters per kg, destroying California's water table. Quinoa: environmental destruction in South America, local food crisis. Soy: monoculture devastation, pesticide-heavy, GMO dominance. Palm oil: orangutan extinction, rainforest destruction. Cashews: human rights abuses, chemical burns, child labor. But cows fart methane, so they're saving the planet with almond milk while California aquifers collapse. This is why vegans are ecologically illiterate.

SAMA HOOLE: [Alfred Pennington put] them on unlimited meat, eggs, and fat with zero carbs or sugar. Results: average weight loss of 22 pounds in 3.5 months while eating to satiety. No hunger. No calorie counting.

The diet worked so well DuPont made it company policy. --Sama Hoole

1956: Alfred Pennington, a DuPont company doctor, is asked to solve obesity problem among executives.

He puts them on unlimited meat, eggs, and fat with zero carbs or sugar.

Results: average weight loss of 22 pounds in 3.5 months while eating to satiety. No hunger. No calorie…

— Sama Hoole (@SamaHoole) November 9, 2025

1956: Alfred Pennington, a DuPont company doctor, is asked to solve obesity problem among executives. He puts them on unlimited meat, eggs, and fat with zero carbs or sugar. Results: average weight loss of 22 pounds in 3.5 months while eating to satiety. No hunger. No calorie counting. The diet worked so well DuPont made it company policy. Pennington published findings: "Treatment of Obesity with Calorically Unrestricted Diets." Medical establishment response: "This contradicts calories in, calories out. Must be wrong." The diet was buried. Calories in, calories out became dogma. On the bright side, Pennington's foray into low carb dieting ended up inspiring a certain Dr Atkins.