P53 protects telomeres https://t.co/TnPyaNNWOF. @Parsifaler
— Jennifer Depew, RD (@deNutrients) August 19, 2021
Telomeres
cap the ends of chromosomes and are crucial for genome stability. The p53protein (TP53) is a vital tumor suppressor, activating the transcription of
numerous genes in response to cell stress. We reported that direct binding of
p53 at human subtelomeres corresponds with local transcription activation and
enhanced telomere stability in the presence of DNA damage.
@barnes_law makes a convincing case that it should be individuals by default, because Supreme Court justices have a history of making abominable decisions in the name of public health and safety due to relying on the recommendations of "experts." https://t.co/cQfP9xrIHK
— Jon A (@Is2021OverYet) January 8, 2022
great share also chaga 'Inonotus obliquus protects against oxidative stress-induced apoptosis and premature senescence' https://t.co/9vyp6GmsQG
— Sonny (@sonny8s) January 8, 2022
As we age, our immune system function deteriorates, leaving us increasingly susceptible to health threats such as cancer, autoimmunity, infections, and chronic inflammation. This process is called immune senescence.
Scientists are studying various methods for countering immune senescence, including young stem-cell mobilized plasma transfusions. Research suggests old blood may contain pro-aging factors whose concentrations are diluted by young-blood transfusions, potentially causing rejuvenating effects.
In addition, several natural interventions, including cistanche, reishi, and zinc may slow or potentially reverse the course of immune senescence.
How Aging Accelerates Immune Decline
Decreased numbers of naïve T cells, or cells that can easily be activated to recognize and respond to diseases like the flu and cancer.
Increased numbers of senescent memory T cells that have lost their ability to divide and function properly and instead release pro-inflammatory molecules.
Decreased natural killer (NK) cell activity, which is linked to increased illness and death from infections, atherosclerosis, and diminished response to the flu vaccine.
Cytomegalovirus infection may be associated with immune senescence, cardiovascular disease, frailty, and mortality.
Some of the above compounds read like effective anti-aging substances. Check out what NCBI says about Herba Cistanche,
Herba Cistanche extracts are pharmacologically active, with a range of functions that include improving chronic renal disease and senile constipation, increasing learning/memorizing ability, treating Alzheimer's disease (AD), and improving immunity.
DM question: "why are de-worming things working against Covid"
— Jennifer Depew, RD (@deNutrients) January 8, 2022
my answer: It is an intracellular infection - spreading cell to cell directly, or by exosomes so tests may be negative for virus, while there are infected cells. Antimicrobials/anti-parasitics seek out cells that...
It has more than one mechanism of action, I was describing the zinc ionophore mechanism that many anti-parasitics all share. They help against cancer or inflammation, & autoimmune conditions use them as treatment too.
— Jennifer Depew, RD (@deNutrients) January 8, 2022
I will add a clue - what those things don't have in common is a parasitic infection. Ginger, turmeric in curry, & hot pepper all have anti-parasitic effects. Cold weather would not effect symptoms of a parasitic infection. Pressure change might possibly but probably not the same
— Jennifer Depew, RD (@deNutrients) January 9, 2022
Spoiler alert, here’s how it ends: https://t.co/KUkVVSIoJr
— To The Lifeboats (@ToTheLifeboats) January 8, 2022
