HESPERIDIN: Reduces markers of heart disease and protects against myocardium structural damage

#hesperidin - protective against heart damage.
I've been pitching that since April 2020 https://t.co/wXmkuQfJ21. #citruspeel https://t.co/y5qWDC9GzL

— Jennifer Depew, RD (@deNutrients) November 22, 2021

That Twitter screenshot of the article comes from the Journal of Hypertension.  Of note from the articles listed therein is the fact that Hesperidin protects the heart.  Other compounds do, too, like Resveratrol, magnesium, vitamin Bs, vitamin D3, and, of course, vitamin C.  When I first tried the Hesperidin/Diosomin, the veins on my legs became visibly stronger, more fortified.  I do love this product.

In most Hesperidin/Diosomin combinations, you're going to get only 100 mg of Hesperidin, so not sure it makes much sense to order any of the 1,000mg of Hesperidin/Diosomin because that 1,000mg refers to the Diosomin. 

These are nutritional compounds taken from citrus fruit.  VeryWellHealth explains that

Although oranges, lemons, and other citrus fruit are known to be an excellent source of vitamin C, these fruits also contain diosmin, a little-known flavonoid compound found to possess antioxidant and anti-inflammatory properties.

I've known and seen examples of older folks suffering from phlebitis, or inflammation of the veins.  This inflammation, if gone unchecked, will show as open wounds or ulcers on the skin.  The folks that I've seen with phlebitis had it on their lower legs near their ankles, which may be common due to poor lower leg circulation.  They were helpless.  I was helpless.  Their doctors were helpless.  The wounds were nasty looking and only reminded these poor souls of the extent of their internal illness, which were other problems. It's just that the ulcerated lower leg looked awful and was, to them and the rest of us at the time, untreatable.   Doctors are of no use.  Hesperidin comes paired with Diosomin because they're both citrus compounds that have healing powers on inflamed veins AND other blood vessels, like the capillaries.  This should be of note to anyone who got vaccinated since the spike proteins tend to settle in the capillary network between veins and arteries.   

Diosmin is often referred to as a phlebotonic, a class of therapeutic agents used to improve the health of veins. It's also said to enhance the health of other types of blood vessels.

First used therapeutically in the 1960s, diosmin is widely available in dietary supplement form. In many cases, diosmin is taken in combination with hesperidin, another citrus fruit flavonoid. A supplement known as "micronized purified flavonoid fraction", or MPFF, is a combination of diosmin with hesperidin, typically in a 9:1 ratio. Diosmin can also be produced by extracting hesperidin from citrus rinds and modifying its components.

HESPERIDIN & DIOSMIN FOR VERICOSE VEINS, SWELLING, & POOR PERIPHERAL CIRCULATION. ALSO HELPS IMMUNE SYSTEM HEAL ULCERS

If you've got circulation problems, you may want to consider using Hesperidin. 

What is it?   Dr. Ray Sahelian says that

Hesperidin is an abundant flavonoid found in citrus fruits. It is the predominant flavonoid in lemons and oranges. The peel and membranous parts of these fruits have the highest hesperidin concentrations. Therefore, orange juice containing pulp is richer in the flavonoids and hesperidin than that without pulp. Sweet oranges (Citrus sinensis) and tangelos are the richest dietary sources of hesperidin. Hesperidin is classified as a Citrus bioflavonoid.

Hesperidin, in combination with a flavone glycoside called diosmin, is used in Europe for the treatment of venous insufficiency and hemorrhoids. Hesperidin, Rutin and other flavonoids thought to reduce capillary permeability and to have anti-inflammatory action were collectively known as vitamin P. These substances, however, are not vitamins and are no longer referred to, except in older literature, as vitamin P.

Hesperidin is an abundant and inexpensive by-product of citrus cultivation. A deficiency of hesperidin in the diet has been linked with abnormal capillary leakiness as well as pain in the extremities causing aches, weakness and night leg cramps. No signs of toxicity have been observed with normal intake or related compounds. Both hesperidin and its aglycone Hesperitin have been reported to possess a wide range of pharmacological properties.

Good.  So Hesperidin is a citrus bioflavonoid.  But instead of drinking the juice from all of these fruits along with the sugars and calories, one should try the supplement and watch their blood vessels become healthy again.  Truly.  I think most people don't consume citrus fruits until they see one because of the citric acid in them.  They're tart.  And the result might be that your blood vessels don't get nourished.  

So what conditions are a sure sign of poor circulation?  NativeRemedies lists them:

The Effects of Poor Blood Circulation

Poor blood circulation can impact the entire body, including:

Effects upon the brain – poor blood circulation can impact the brain causing fatigue, dizziness, memory loss, and frequent and unexplained headaches.

Effects upon the heart – poor blood circulation can have an impact on the heart, causing inability to perform simple aerobic activities like climbing stairs without breathlessness; high blood pressure and cholesterol, and chest pain can be other symptoms.

Heart attack and stroke are major risks of poor circulation that remains untreated.

Effects upon the liver – symptoms of poor blood circulation in the liver can include lack of appetite or unexplained weight loss, and changes in skin tone.

Effects upon the kidneys – poor circulation to the kidneys are typically the result when there is swelling of the hands, feet and ankles. Other symptoms can include fatigue, altered heart rate and rise in blood pressure.

Effects upon the limbs – with poor circulation, cramps in the limbs, numbness and varicose veins can appear as symptoms.

The most significant indications that you may need hesperidin supplements are signs of unhealthy circulation, including an abnormal leaking of blood from the capillaries or visible bruising. This condition typically causes discomfort, weakness, and cramps at night, especially in the legs. Additional signs that Hesperidin could help you include heaviness, itching, and swelling in the extremities, especially in the upper arms. Hemorrhoids and venous ulcers may also indicate that hesperidin supplements may benefit you.

To manage the swelling, Extnd-Life explains that 

a combination of Hesperidin, Butcher's Broom, Vitamin C and methyl chalcone may reduce swelling of the upper arm.  

I have never heard of Methyl Chalcone, and didn't realize that people have problems with swollen upper arms.  Most of the swelling that I've heard complained about is in the lower extremities, lower arms and hands.  Methyl Chalcone is a derivative of Hesperidin.  Interesting.  So as an isolate, it seems to benefit dark circles under the eyes, that raccoon effect I've seen on some stressed out diabetics.  TruthinAging explains that 

Hesperidin Methyl Chalcone is a derivative of the flavonoid hesperidin and is found in citrus fruits like oranges and grapefruit and is often used to reduce dark circles under the eyes. According to CosmeticsCop.com, one study documented that it lowers the filtration rate of capillaries, and less blood flowing though capillaries close to the surface of the skin potentially means less dark bluish discoloration under the eyes. It's also thought to prevent leaking from the veins below the eyes, also preventing the dark blue look from blood leaking below the surface of the skin.

Extend-Life continues: 

An oral supplement of Hesperidin and Diosmin may help support the immune system's ability to heal ulcers, especially venous ulcers.  This application typically lasts for two months.  

Now that sounds incredible.  If you've got capillaritis, you should give Hesperidin a try.  

Bill Sardi makes a very interesting comment about how bioflavonoids [or Hesperidin] works with Vitamin C:

Tighten the capillaries. Weak capillaries can exacerbate many eye problems. Vitamin C tightens capillaries and is essential for our retinas (also for our lungs and kidneys). To enhance the action of vitamin C we need bioflavonoids. They are tart and dry. He mentioned pomegranate and lemon rind.

I've tried the Hesperidin myself and have seen and felt its benefits after only a week.  Most protocols call for two months.  I am looking forward to seeing the results.