Showing posts with label C. difficile and the immune system. Show all posts
Showing posts with label C. difficile and the immune system. Show all posts

Thursday, March 23, 2023

"There is a need for microbes to cohabitate and repopulate, refloralize the gut"

6:00  What are antibiotics?  Fungus of a potato.  It's another microbe, right?  There is a need for microbes to cohabitate and repopulate, refloralize the gut, right?  So the whole process.  Instead of microbiome transplant, figure out what are in the foods.  How do you supplement?  So you're missing the gut microbes, firmicutes, and Bacteroides.  The importance of firmicutes:

This process is called fermentation. When bacteria ferment dietary fibres, they produce metabolites, including vitamins and short-chain fatty acids, like butyrate. Butyrate helps prevent inflammation and fuels the cells of the gut lining, which maintains a healthy colon.

Many members of the Firmicutes phylum are probiotic. Lactobacillus, a probiotic bacterium often found in yoghurt and other fermented dairy products, belongs to this phylum. These microbes make acetate, another health-promoting short-chain fatty acid, as well as lactate, and antimicrobial substances that prevent pathogens from disturbing your health.
 
Some pathogenic species belong to the phylum, too. For example, Clostridium perfringens is a type of bacteria that causes gastrointestinal infections. There is also Staphylococcus aureus, a common cause of some serious infections.   

8:13  Fecal transplant is only approved for Clostridium difficile.   


As a specialist in gastroenterology, internal medicine, and hepatology, Dr. Hazan has used her expertise in many regards over the last two decades. Dr. Hazan is also the Founder & CEO of the Malibu Specialty Center and Ventura Clinical Trials, where she conducts and oversees clinical trials for cutting-edge research on various medical issues. Dr. Hazan is a top clinical investigator for multiple pharmaceutical companies and also acts as the series editor of Practical Gastroenterology on the microbiome, a peer review journal that reaches 18,000 gastroenterologists. She was and is a speaker for World Congress of Digestive Disease, MAGI, Microbiome Congress, International Drug Discovery Science and Technology Conference, and NIST (National Institute of Standards and Technology).

12:20 Bacteria is 20x bigger than a virus. A virus secretes cytokines. Bacteria secrete toxins. The key is to keep them from secreting.

PROBIOTICS
The problem with probiotics is that they're not really tested at the level. We looked at patients that were given low-quality, these over-the-counter, CVS generic probiotics, and those people had zero bifidobacteria in their gut as opposed to people taking products from GMP [Good Manufacturing Practice] facilities, where they're validated, and verified, where they see that it's a live microbe that we're giving, and they have a lot of . . . . You may not need probiotics. Kids who are healthy do not need anything. What you want to do is make your body work. You want your enzymes to If you've trashed your microbiome, you're going to need your probiotics. and bifidobacteria are very fragile. It's something that goes up one day, and the next day you're doing something that causes it to go down, and then it's up again. Stress and alcohol cause your bifidobacteria to fluctuate up and down. Fighting with a spouse, friend, or coworker followed by 2 glasses of tequila, eating shrimp infected with whatever and eating strawberries with e coli, and all of this stuff. Or you took antibiotics prescribed by your dentist, and all of a sudden you take all that great bifidobacteria that were fighting against COVID is no longer available, and now you have that perfect storm. I went to the dentist, got antibiotics, and two weeks later I got COVID.

She does admit that she likes Paxlovid, a Pfizer product, but I'd heard too many concerns to trust that myself. She likes Regeneron for the Delta strain. So many strains of the virus, we're seeing Delta, we're seeing Omicron, is it Omicron Plus? When we were in "Omicron," in Ventura, we were seeing Delta still. Because they test the septic, right, they're not testing the individual. As they were removing Regeneron, I was still seeing Delta. Wait, a minute, why are we removing Regeneron? Because I am seeing the whole strain in my office, in my lab. Had doctors had the ability that I have, which is a genetic sequencing lab that sees and follows the evolution of the virus, doctors would have been more equipped to treat COVID. We want to have the ability, as we write more data, to make it available to doctors