I had always thought of B-12 as an energy tablet, one that people with low-energy take. But B-12 serves a much greater function beyond boosting
of energy. It restores nerve and brain function. How so? It rebuilds the myelin sheath that protects the spinal column as well as all of the individual nerves in the brain. Keeping this myelin sheath in tact means that your organ signaling will function strong and far longer than most. Remember: protect that myelin sheath. The Methylcobalamin form of B12 does this.
The gist of this article is that one, we don't get enough B12 from our diet for a variety of reasons; all this to say that we all should be supplementing with methylcobalamin.
I was a little disappointed by a couple of things in this article. One, when Mercola, or his ghostwriter, says lists the various dosages for different individuals, he leaves out what MEN should take. He lists newborns, children up to 13, "people" 14 and older, pregnant women, and breastfeeding women. But no mention of men, as if men don't have specific and certain requirements that are distinctive from "people age 14 and older." Disappointing.
Second, as the article decries the horrors of B12 deficiency, the writer fails to point out some foods that deplete our vitamin B stores, foods like MSG, coffee, tea, and dental amalgams. There are other foods as well as prescription medicines that outright block or impair vitamin B absorption, while other things deplete your body's stores of the nutrient. Why is this important? Stress and sleep deprivation can also contribute to B depletion, and you don't want to get caught at work expressing mild psychiatric symptoms for your coworkers may not be so understanding, ahem, if you know what I mean.
The gist of this article is that one, we don't get enough B12 from our diet for a variety of reasons; all this to say that we all should be supplementing with methylcobalamin.
I was a little disappointed by a couple of things in this article. One, when Mercola, or his ghostwriter, says lists the various dosages for different individuals, he leaves out what MEN should take. He lists newborns, children up to 13, "people" 14 and older, pregnant women, and breastfeeding women. But no mention of men, as if men don't have specific and certain requirements that are distinctive from "people age 14 and older." Disappointing.
Second, as the article decries the horrors of B12 deficiency, the writer fails to point out some foods that deplete our vitamin B stores, foods like MSG, coffee, tea, and dental amalgams. There are other foods as well as prescription medicines that outright block or impair vitamin B absorption, while other things deplete your body's stores of the nutrient. Why is this important? Stress and sleep deprivation can also contribute to B depletion, and you don't want to get caught at work expressing mild psychiatric symptoms for your coworkers may not be so understanding, ahem, if you know what I mean.
Several of the B vitamins (B2, B6, B9, and B12) affect brain metabolism and contribute to psychiatric illnesses like depression and behavioral disorders.Not good. Make sure you take the Methylcobalamin.
Find the article at Mercola.com.
According to the U.S. Department of Agriculture (USDA), nearly
40 percent of the U.S. population have marginal vitamin B12 status and 9
percent are deficient.1 Vitamin
B12 insufficiency and deficiency increase your risk of serious health problems,
many of which mimic more serious neurological diseases and can easily lead to
misdiagnosis and improper treatment.
Neurological problems, in particular, are a possibility even at the “low normal” range at or just below 258 picomoles per liter (pmol/L). A level of 148 pmol/L or less is considered a deficiency state. As noted by the USDA:2
Deficiency can cause a type of anemia marked by fewer but larger red blood cells. It can also cause walking and balance disturbances, a loss of vibration sensation, confusion and, in advanced cases, dementia. The body requires B12 to make the protective coating surrounding the nerves. So, inadequate B12 can expose nerves to damage.
Indeed,
vitamin B123 is
vital for many functions throughout your body. B12 is required for:
B12 DEFICIENCY MIMICS MANY SERIOUS NEUROLOGICAL DISORDERS AND DISEASES
As noted
in the featured video, B12 deficiency can look exactly like multiple sclerosis, Alzheimer’s disease and autism. The film is made by registered nurse
Sally Pacholok (see her B12 Awareness site), a leading advocate for B12 deficiency awareness.6 According
to the National Institutes of Health (NIH), a deficiency can even affect a
woman’s Pap test, which screens for cervical cancer.
Low B12 can affect the appearance of cervical cells, which can
result in a false positive.7 Deficiency
also raises your risk of heart disease. Vegans or strict vegetarians who
abstain from animal products and do not supplement their diet with vitamin B12
will typically become anemic. Nervous and digestive system damage can also
result.8
Claims
that B12 is present in certain algae, tempeh and brewer’s yeast fail to take
into account that the B12 analogues present in these foods are not
bioavailable. The only reliable and absorbable sources of vitamin B12 are
animal products. However, even animal foods have become a questionable source
thanks to modern farming practices and, for this reason, many experts now
believe most people really need to take a B12 supplement to ensure healthy B12
status.9
B12 DEFICIENCY WIDESPREAD EVEN AMONG MEAT EATERS
Interestingly,
research shows no association between B12 blood levels and consumption of meat,
poultry and fish — the primary sources of B12.10 According
to the researchers, rampant B12 insufficiency is not due to lack of meat
consumption. Rather, the vitamin simply isn’t being properly absorbed. B12 is
tightly bound to proteins and high acidity is required to break this bond. In
essence, a lot of people simply do not have sufficient stomach acid to separate
the B12 from the protein.
The
researchers speculate that the widespread use of antacids plays a significant
role, especially among younger people. In a previous article,11 Dr.
Jennifer Rooke, assistant professor in the department of community health and
preventive medicine at Morehouse School of Medicine, also notes that factory
farmed meat simply does not contain the B12 levels we’re used to.
The reason
for this is because animals raised in concentrated animal feeding operations (CAFOs) aren’t fed their natural diet. Cows are
fed corn and grains, most of which are genetically engineered (GE) and loaded
with pesticides, rather than grass. The same goes for chickens, the natural
diet of which are insects, worms, seeds and berries, not GE corn.
“It is
true that animal products contain B12, and strict vegetarians/vegans are at
risk for B12 deficiency, but absorbing B12 from animal products is a very
complex process and people who eat meat may be at equal or greater risk for B12
deficiency,” Rooke writes. The reason CAFO animals don’t produce as much B12 is
because B12 is made by bacteria that live in both soil and the guts of animals.
Cows and chickens raised on pasture obtain the vitamin from the dirt on their
food.
Pesticides
also kill off soil bacteria, which is why conventionally grown grains are not a
good source of B12, and CAFO animals are routinely given antibiotics, which also kill of these
beneficial microbes. “In order to maintain meat a source of B12 the meat
industry now adds it to animal feed; 90 percent of B12 supplements produced in
the world are fed to livestock.
Even if you only eat grass fed organic meat you
may not be able to absorb the B12 attached to animal protein. It may be more
efficient to just skip the animals and get B12 directly from supplements,”
Rooke writes.
PREGNANT WOMEN BEWARE: B12 DEFICIENCY CAN CAUSE SEVERE NEUROLOGICAL DAMGAGE IN YOUR CHILD
While
vegans are urged to augment their B12 intake by stocking up on nutritional
yeast, coconut oil and fortified coconut milk,
a strict vegan or even vegetarian diet is not recommended. In fact, there are
cases in which a deficiency causes serious brain abnormalities. Women of
childbearing age also need to be aware that B12 deficiency will place their
offspring at risk.
If you’re
deficient and breastfeed, your child will also be deficient, and may develop
neurological symptoms — symptoms that are frequently misdiagnosed as autism
and/or other neurological diseases. It’s really critical to catch a B12
deficiency early, as impaired brain and nerve development can be very difficult
to correct once the damage is done. In adults, B12 deficiency can develop in
about six years.12 That’s
how long it takes to deplete your body’s B12 stores.
Babies,
however, do not have B12 stores, especially if the mother was deficient during
pregnancy, so side effects can develop far more rapidly. Babies whose moms had
a B12 deficiency during pregnancy also have a higher risk of developing Type 2
diabetes and other serious metabolic problems.13
A
deficiency can be corrected by weekly shots of vitamin B12 or daily high-dose
B12 supplements. Mild cases may also be corrected by increased intake of
vitamin B12-rich foods. A detailed list of the B12 amounts of different foods
can be found on the NIH website.14Some
of the richest sources include clams, beef liver, wild rainbow trout and wild
sockeye salmon.
B12 DEFICIENCY PLAYS A ROLE IN DEPRESSION AND OTHER PSYCHIATRIC CONDITIONS
Aside from
symptoms mimicking autism and Alzheimer’s, B12 deficiency also contributes to
depression and other psychiatric conditions. (Other B vitamins, including
niacin (B3), B6, biotin (B8) and folate (B9) deficiencies can also produce
psychiatric effects.) For example, research has shown vitamin B12 deficiency
can trigger confusion, agitation, depression, mania, psychosis and paranoid
delusions.15,16
One study17,18 found vitamins B6, B8 (inositol) and B12 in combination
were very effective for improving schizophrenic symptoms when taken in high
doses — more so than standard drug treatments alone. Low doses were
ineffective. One of the reasons for this may be related to the fact that
schizophrenics tend to have abnormalities in their B12 and glutamate pathways.19
LOW B12 IMPLICATED IN MIGRAINES
B12, along
with B6 and folic acid, has also been shown to reduce the frequency, severity
and disability of migraines. In one study,20daily
vitamin supplements produced a twofold reduction in migraines over a six-month
period. Certain gene mutations and dysfunctions can lead to higher levels of
homocysteine production, which can make you more susceptible to migraine
attacks.
Vitamins
B6 and B12 help to optimize your homocysteine levels. The scientists also found
that depending on your genotype, you may need a higher or lower dose to
benefit. People with TT genotypes, which have a lower enzymatic rate,
metabolize less homocysteine than those with C allele carriers. As a result,
the former experience less of a benefit from the supplementation and require
higher doses.
SIGNS OF VITAMIN B12 DEFICIENCY
If you’re frequently
beset by fatigue and general lack of energy, you may be experiencing the onset
of B12 deficiency. Other seemingly unrelated symptoms such as poor memory,
shortness of breath, loss of taste and smell, depression and
tingling in your extremities, can be indicative of low B12.
Anxiousness and
depression may occur because a B12 shortage depresses the brain chemical
serotonin, a neurotransmitter linked to your brain’s pleasure centers, and
dopamine, the mood regulator registering memory and mood. Unless there’s an
intervention, low B12 levels may even lead to paranoia, delusions and
hallucinations. Other signs and symptoms include:21
MOST PEOPLE ARE AT RISK FOR B12 DEFICIENCY
There are a number of key
reasons for a B12 deficiency, including the following. Unfortunately, doctors
frequently overlook these common contributing causes, and B12 deficiency is
frequently misdiagnosed as something far more serious.
Needless to say, when a
deficiency is misdiagnosed as depression, Alzheimer’s, autism or other serious
disease, the root cause remains unaddressed, and no amount of treatment will be
significantly effective. So, if any of these situations apply to you, be
particularly mindful of your B12 status, especially if you have symptoms
associated with deficiency.
HOW MUCH VITAMIN B12 DO YOU NEED AND WHICH TYPE IS BEST?
The recommended dietary
allowance for vitamin B12 is:27
- 0.4 to 1.8
micrograms (mcg) for newborns and children up to 13, depending on their
exact age
- 2.4 mcg for
people age 14 and older
- 2.6 mcg for
pregnant women
- 2.8 mcg
for breastfeeding women
Fortunately, you don’t need to worry about overdosing on B12 because it’s water soluble, so your body will simply flush out any excess. The type of B12 you use, however, is a factor worthy of consideration. While cyanocobalamin is the form of B12 found in most supplements, this form is far from ideal and does not occur naturally in foods. As explained by Dr. Peter J. D’Adamo:28
As the name implies, cyanocobalamin contains a cyanide molecule. Most people are familiar with cyanide as a poisonous substance. Although the amount of cyanide in a normal B12 supplement is small and from a toxicology point, viewed as insignificant, your body will still need to remove and eliminate this compound. This removal is accomplished through your detoxification systems with substances like glutathione being very important for the elimination of the cyanide.
A far better form of B12
— especially for the support of nervous system health and healthy vision — is
methylcobalamin, which is the naturally occurring form found in food. It’s more
absorbable and your body retains it in greater amounts than cyanocobalamin.29Considering
the many health risks associated with B12 deficiency, and the fact that CAFO
animal products — which is what most people eat — tend to be low in B12, it may
be wise for most people to take a high-quality methylcobalamin supplement.
SOURCES AND REFERENCES
- 1, 2 USDA, Vitamin B12 Deficiency
- 3 Eating Our Future, Vitamin B12 Deficiency
- 4 Cell Metabolism November 4, 2014; 20(5): 769–778
- 5 PNAS February 14, 2017; 114(7): E1205-E1214
- 6 B12awareness.org
- 7 Health.com March 27, 2018
- 8 The Nutrition Almanac, 3rd ed. p. 32-33; Garrison,
R. & Somer, E. The Nutrition Desk Reference, 3rd ed., (Keats
Publishing; CT), p. 126
- 9 European Journal of Nutrition 2017 Feb;56(1):283-29
- 10 USDA, Vitamin B12 Deficiency
- 11 Baltimore Post-Examiner October 30, 2013
- 12 Dietary Reference Intakes for Thiamin,
Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid,
Biotin, and Choline, Estimation of the
- 13 Science Daily November 7, 2016
- 14 NIH.gov, Vitamin B12 Fact Sheet
- 15 British Medical Journal 956 Dec 15; 2(5006):
1394–1398
- 16 British Medical Journal 956 Dec 15; 2(5006):
1394–1398 (Full article, PDF)
- 17 Psychological Medicine February 16, 2017, DOI:
https://doi.org/10.1017/S0033291717000022
- 18 Medical News Today February 16, 2017
- 19 PeerJ Journal 3:e1140
- 20 Pharmacogenet Genomics. 2009 Jun;19(6):422-8
- 21 Harvard, Vitamin B12
- 22 Clinical Chemistry August 2008
- 23 American Family Physician 2017 Sep 15;96(6):384-389
- 24 JAMA 2013;310(22):2435-2442
- 25 Health.com March 27, 2018
- 26 Effects of Antibiotic-Induced Vitamin B12 Deficiency
With and Without Oral Administration of Vitamin B12 (PDF)
- 27 NIH.gov, Vitamin B12 Fact Sheet
- 28 DaDamo.com, Cyanocobalamin versus Methylcobalamin
- 29 Just Vitamins, Cyanocobalamin versus Methylcobalamin
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