SAMA HOOLE: Your brain is 60% fat, burns 500 calories a day, and needs fats like DHA…only found in animal foods.

5. The Brain Prefers Fat

Your brain is 60% fat, burns 500 calories a day, and needs fats like DHA…only found in animal foods.

Without the caloric density of fat, as well as the key nutrients, our ancestors would never have been able to support such a brain.

And in case you…

— Sama Hoole (@SamaHoole) August 24, 2025

Our Keto Advantage We slip into ketosis effortlessly, without needing a calorie deficit. This ability is unique to our species. During fasting, we develop physiological insulin resistance, preserving glucose for the brain while the body runs on fat.

That’s not a dysfunction. It’s ancestral design. We are built to run on fat, and built to fast.