Showing posts with label prion disease. Show all posts
Showing posts with label prion disease. Show all posts

Sunday, October 2, 2022

NATTOKINASE DEGRADES AND REDUCES AMYLOID FIBRILS ASSOCIATED WITH ALZHEIMER'S

Thursday, September 1, 2022

In contrast to conventional studies of amyloidogenic drugs, quercetin accelerates fibrillation of prion protein. (A GOOD thing.)

QUERCETIN

Some highlights regarding Quercetin and amyloids:

Quercetin binding to prion protein is determined, and the network of the binding site at the molecular level is visualized.

In contrast to conventional studies of amyloidogenic drugs, quercetin accelerates fibrillation of prion protein. (A GOOD thing.)

Quercetin turns fibrils into protease-sensitive, structurally loose and non-cytotoxic forms.

Quercetin shows its uniqueness from typical antiamyloidogenic drugs.

Quercetin treatment can disaggregate moPrP (mouse prion) fibrils and lead to the formation of the proteinase-sensitive amorphous aggregates. Furthermore, quercetin-bound fibrils can reduce the membrane disruption of erythrocytes.

Quercetin is distinct from the typical function of antiamyloidogenic drugs that inhibit the formation of amyloid fibrils.

CURCUMIN

Curcumin may be a powerful alloy and “wing man” to Quercetin.

Curcumin alone reduced prion fibril formation significantly.

Curcumin effectively rescues the cells from apoptosis and decreases the ROS level caused by subsequent co-incubation with prion amyloid fibrils.

I believe urgent clinical trials are needed to assess the efficacy of Quercetin and Curcumin as prophylaxis, and treatment of both Acute and Long COVID.

https://www.sciencedirect.com/science/article/pii/S0753332222005662#

https://pubmed.ncbi.nlm.nih.gov/33187342/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235698/

Tuesday, June 14, 2022

Curcumin alone reduced prion fibril formation significantly

This is good news.   

QUERCETIN

Quercetin shows its uniqueness from typical antiamyloidogenic drugs. 

Quercetin treatment can disaggregate moPrP (mouse prion) fibrils and lead to the formation of the proteinase-sensitive amorphous aggregates. 

Furthermore, quercetin-bound fibrils can reduce the membrane disruption of erythrocytes. 

Quercetin is distinct from the typical function of antiamyloidogenic drugs that inhibit the formation of amyloid fibrils. 

CURCUMIN 

Curcumin may be a powerful alloy and “wing man” to Quercetin. 

Curcumin alone reduced prion fibril formation significantly. 

Curcumin effectively rescues the cells from apoptosis and decreases the ROS level caused by subsequent co-incubation with prion amyloid fibrils.

 

Friday, January 21, 2022

RESVERATROL TO THE RESCUE: Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity

You might be interested in Bill Sardi's Resveratrol formula, called Longevinex.  Check out his articles on longevity at the left-hand margin of this site under the headline, "Aging & Anti-aging."

Monday, November 22, 2021

Want to Treat Gastric Ulcers? Try ZINC CARNOSINE

The world of disease is complicated, unknown, with so many receptors, binding proteins, epithelial cells on membranes that it's quite difficult to make sense of it all.  Sometimes the best we can do is rely on the old standbys, like vitamin D3, vitamin A, vitamin C, vitamin E, zinc, and others to keep ourselves free of pathogens--viruses, bacteria, etc.  And oftentimes the fearmongering around diseases seems interminable.  You find out one thing about a pathogen, and you panic.  Doctors love it when they can cause you to panic when they give you or a loved one a diagnosis of cancer or some other progressive, degenerative, even debilitating disease.  For this reason, medical doctors have lost me.  Recently, I'd learned that the spike proteins that are invading our bodies via the vaccines or transmission of exosomes are recking havoc on our cells and cell membranes, and the quality of our blood.  And given this nightmare, I don't see how folks are still worried about COVID.  COVID seems to be the last of our worries. Was recently reading about prion disease, proteins that cause other proteins to fold and malfunction.  The kinds of conditions caused by prion disease are Parkinson's, Mad Cow Disease, Alzheimer's [I thought this was caused by amyloid plaque], and others.  John Hopkins Medical reports that

A prion is a type of protein that can trigger normal proteins in the brain to fold abnormally. Prion diseases can affect both humans and animals and are sometimes spread to humans by infected meat products. The most common form of prion disease that affects humans is Creutzfeldt-Jakob disease (CJD).

Which is frightening enough.  Science can be fascinating, but if you get a talented scientist placed under the influence of mass murders, like Ralph Baric of North Carolina University, then the world is doomed.

But maybe, just maybe there are some small, insignificant interventions that people can take to either prevent disease or outright cure it into non-existence.  Zinc is one such powerful compound as to elicit respect for what it can do to restore and maintain health.  Here is what PubMed has to say about zinc

Zinc (Zn) is abundantly present in the brain, and accumulates in the synaptic vesicles. Synaptic Zn is released with neuronal excitation, and plays essential roles in learning and memory. Increasing evidence suggests that the disruption of Zn homeostasis is involved in various neurodegenerative diseases including Alzheimer's disease, a vascular type of dementia, and prion diseases. Our and other numerous studies suggest that carnosine (β-alanyl histidine) is protective against these neurodegenerative diseases. Carnosine is an endogenous dipeptide abundantly present in the skeletal muscles and in the brain, and has numerous beneficial effects such as antioxidant, metal chelating, anti-crosslinking, and anti-glycation activities. The complex of carnosine and Zn, termed polaprezinc, is widely used for Zn supplementation therapy and for the treatment of ulcers. Here, we review the link between Zn and these neurodegenerative diseases, and focus on the neuroprotective effects of carnosine. We also discuss the carnosine level in various foodstuffs and beneficial effects of dietary supplementation of carnosine.

The complex of carnosine and Zn, termed polaprezinc sounds interesting.  What is that exactly?  It's Zinc Carnosine, and it's used to heal gastric ulcers.