Don’t forget Resveratrol https://t.co/pJilDmD0zY
— ImmaCreep (@imma_creep) January 22, 2022
You might be interested in Bill Sardi's Resveratrol formula, called Longevinex. Check out his articles on longevity at the left-hand margin of this site under the headline, "Aging & Anti-aging."
The Washington Times reports that scientists were able to reverse the graying of hair on mice and smooth the wrinkles of the same critter. And with this result, it is advanced that the treatment will work on humans. Maybe. Good luck bringing this to market.
Science has made mice look good by reversing age-related wrinkles and hair loss at the genetic level. Humanity could get a similar make-over in the future.They introduced a specific gene mutation on a test mouse, which prompted a change in profound appearance. Within four weeks, the mouse had developed wrinkled skin and extensive, visible hair loss. When regular function was restored within the gene by turning off the culprit mutation, the mouse returned to a previous life of smooth skin and luxurious fur only two months later — deemed “indistinguishable” from a healthy mouse of the same age.
“To our knowledge, this observation is unprecedented,” said Keshav Singh, a professor of genetics who led the study.
“This mouse model should provide an unprecedented opportunity for the development of preventive and therapeutic drug development strategies to augment the mitochondrial functions for the treatment of aging-associated skin and hair pathology and other human diseases in which mitochondrial dysfunction plays a significant role,” Mr. Singh said in a statement.“
Oh, I see. So what we've learned, then, is that to reverse aging one needs to repair the mitochondrial function. But we already have that capability. And for a little pushback on the study cited above, let it be known that the most important concern when it comes to reversing aging is not gene mutation, as was conducted in the experiment, but "rather the dynamic ability of genes to make proteins."Wrinkled skin and hair loss are hallmarks of aging. What if they could be reversed?” asked researchers at the University of Alabama at Birmingham — who appear to have accomplished that feat, according to the research team.
While gene mutations only account for ~2% of all disease, most chronic age-related disease doesn’t involve faults in gene structure but rather the dynamic ability of genes to make proteins (called gene expression or gene silencing) which is referred to as epigenetics.Sardi adds that
. . . inherited gene mutations may be inevitable and produce single-gene disorders such as cystic fibrosis, sickle cell, muscular dystrophy or Huntington’s disease. But aging and its accompanying diseases (diabetes, arthritis, cancer, heart, brain and liver disease) are modifiable.I'll add two more points by Sardi on an anti-aging compound.
The diet, namely a calorie-restricted diet, practiced daily or intermittently, doubles the lifespan and healthspan [my emphasis] of lower forms of life (fruit flies, roundworms, and mice). Or a molecular mimic (i.e. anti-aging pill) may target the same genes as food deprivation and provide a shortcut to allay the ravages of aging.
In other words, what would taken a lifetime to achieve in a laboratory mouse was exceeded by 9-fold in just 12 weeks. Eighty-two percent (82%) of the same 832 longevity genes were switched in the same direction (on or off) as a limited calorie diet by the resveratrol matrix (Longevinex®), which is a commercially available nutraceutical. That is the closest anyone has come to a molecular mimic of a calorie-restricted diet.But get Sardi's Longevinex. It's one of the few Resveratrol products that's actually been tested.
Four years ago (2013) a mega-dose of resveratrol was shown to remarkably reduce damage to the brain 5and 12 hours AFTER mild brain trauma. The intentional brain injury was included in lab animals and overcome with a human equivalent single dose of 7000 milligrams of resveratrol, which would be impractical and problematic dose over the long term. But it does provide evidence for the use of resveratrol in brain injuries.
In anotheranimal study a similar protective effect was observed in laboratory animals that had heavy weights dropped on their skulls and mega-dose resveratrol had a healing effect upon brain neurons after the event.
In yet another animal study daily mega-dose resveratrol was administered and reduced brain edema (swelling) and improved cognition (thinking). Researchers concluded, “resveratrol may represent a novel therapeutic strategy for traumatic brain injury.”
There are other corroborative studies.
Resveratrol is not just a preventive but also therapeutic (i.e., it works to restore brain tissues after trauma).
While resveratrol has recently gained widespread public and scientific attention for its age-prolonging qualities, Longevinex® is a unique multi-ingredient dietary supplement that is more than just resveratrol. The ingredients in Longevinex® are designed to address five major theories of aging: the free radical/antioxidant theory, the hormonal theory (estrogen/testosterone), the mitochondrial (cell energy) theory, the cell cleansing or autophagy theory, and the metabolic, calorie restriction/Sirtuin gene activation theory. There is another theory of aging, Overmineralization, also addressed by the ingredients in Longevinex®, which may supercede and better explain other theories of aging.
With studies that show they are among the healthiest people on earth, the plan is inspired by the Greek monks of Mount Athos and their Mediterranean diet. Amazingly, research has shown that within their tight-knit communities Cancer is almost unheard of, strokes and cardiac arrests are pretty much non existent and diseases like Alzheimer’s and Parkinson’s are extremely rare. The monks have also been proven to live, on average, several years longer than men living in mainland Greece.So what do they eat?
meals are based around a typical Greek peasant diet (don’t panic, it’s better than it sounds), with a high proportion of vegetables, beans, fruits, nuts, whole grains and olive oil.
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| Olives are permitted on Fasting Days |
The plan focuses on a pattern of three varying diet days – three days for ‘fasting’, three days for moderate eating and one ‘feast’ day, where you can eat and drink whatever you like.
Throughout the process, you are encouraged to have a high intake of seasonal vegetables, fish and chicken while also allowing yourself – as the monks do – a moderate intake of red wine.
