This is good news.
— Todd McKenzie (@ToddEBear) June 13, 2022
QUERCETIN
Quercetin shows its uniqueness from typical antiamyloidogenic drugs.
Quercetin treatment can disaggregate moPrP (mouse prion) fibrils and lead to the formation of the proteinase-sensitive amorphous aggregates.
Furthermore, quercetin-bound fibrils can reduce the membrane disruption of erythrocytes.
Quercetin is distinct from the typical function of antiamyloidogenic drugs that inhibit the formation of amyloid fibrils.
CURCUMIN
Curcumin may be a powerful alloy and “wing man” to Quercetin.
Curcumin alone reduced prion fibril formation significantly.
Curcumin effectively rescues the cells
from apoptosis and decreases the ROS level caused by subsequent
co-incubation with prion amyloid fibrils.
