Showing posts with label Prion Fibril. Show all posts
Showing posts with label Prion Fibril. Show all posts

Tuesday, June 14, 2022

Curcumin alone reduced prion fibril formation significantly

This is good news.   

QUERCETIN

Quercetin shows its uniqueness from typical antiamyloidogenic drugs. 

Quercetin treatment can disaggregate moPrP (mouse prion) fibrils and lead to the formation of the proteinase-sensitive amorphous aggregates. 

Furthermore, quercetin-bound fibrils can reduce the membrane disruption of erythrocytes. 

Quercetin is distinct from the typical function of antiamyloidogenic drugs that inhibit the formation of amyloid fibrils. 

CURCUMIN 

Curcumin may be a powerful alloy and “wing man” to Quercetin. 

Curcumin alone reduced prion fibril formation significantly. 

Curcumin effectively rescues the cells from apoptosis and decreases the ROS level caused by subsequent co-incubation with prion amyloid fibrils.