Showing posts with label Spike Protein. Show all posts
Showing posts with label Spike Protein. Show all posts

Friday, March 1, 2024

SASHA LATYPOVA: if you were claiming a specific mechanism of action, you need to demonstrate it. And that's in the manufacturing documentation . . . None of this was done. Not only that, we later learned that they faked their Western blots


There was no evidence that they were making that Spike protein that they were claiming that they were making ever.  And they have never demonstrated that they can make it actually.  There's not a single scientific publication.  In fact, there was recently a publication showing the opposite, showing that they are making aberrant proteins because of that pseudouridine substitution apparently it creates these skipping the frames and they're making different proteins every time.  So how is it that the claimed mechanism of action the most important part claimed mechanism of action is oh we're going to give you this mRNA code and your cells are going to make these specific Spike protein with the specific virus or variance and now they have these boosters for variants how do you prove that you can do it if you've never demonstrated that you can make one consistent Spike protein?

00:52. So they were measuring instead the amount of antibodies right is that what you're talking about they're measuring the antibodies but never the spike protein in the blood of a human?

01:00. Right, so as a manufacturer, if you were claiming a specific mechanism of action, you need to demonstrate it.  And that's in the manufacturing documentation, so they were supposed to make, for example, a cell assay showing that at least in the cell, ideally, you would do it in an animal model, but at least in some cell lines show that you can actually by putting this mRNA in there, it will make the specific spike protein this Wuhan, whatever you're calling the spike protein, or for Omicron or for Delta, they're claiming all sorts of variants now.  None of this was done.  Not only that, we later learned that they faked their Western blots, and Western blots is one of the assays that you do to characterize those spike proteins that you're making.  Well, guess what?  They faked them. They just computer-generated them.  They never produced the real images and even the computer-generated ones we're showing spike proteins of different weight, not the Wuhan one.  It's as awful as it gets.  In the U.S., it's completely disregarded as I'll explain the legal framework.  But in EMA because of the conditional marketing approval, this was a condition of their approval that they will eventually submit that data to the regulators.  They never did.  Never did.  They just abandoned that requirement altogether.   

Thursday, March 31, 2022

Spike protein causes the glial cells, the repair cells in your brain, to self-destruct

Okay, this is not good.  None of the news coming from vaccinated individuals is good.  It's going to require a lifetime of care.  The spike protein crosses the blood brain barrier, BBB, and produces cognitive deficits and psychiatric problems.  Meaning that you'll lose your mind unless you slow this process down by consuming neuroprotective nutrients, like fish oils, like the whole spectrum of B vitamins.  B5 for youthfulness and longevity.  B6 for healthy micro gut biome. B12 for nerve regeneration.  Far-soluble B1 [Allithiamine, lipothiamine, and or benfotiamine] to protect your autonomic nervous system that automatically regulates all of your vital organs.  See this post.  What follows is extracted from the tweet above.

People worldwide are currently suffering from the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1,2. Increasing evidence has shown that COVID-19 patients not only manifest respiratory-related symptoms, but also develop neurological and psychiatric symptoms, depending on the stage of infection, ranging from headache to cognitive and mood disorders3,4. According to clinical studies, 19% and 14% of COVID-19 patients develop depression and anxiety, respectively5 and 10–20% suffer from cognitive impairment6. Therefore, it is obvious that SARS-CoV-2 somehow affects the central nervous system (CNS), but the molecular and cellular mechanisms are still elusive. Previous studies suspected direct SARS-CoV-2 infection into the CNS, as SARS-CoV-2 spike protein and transcripts were detected in post-mortem brains. Then, as a port of CNS entry, SARS-CoV-2 invasion via olfactory receptor neurons was proposed7. However, a recent study using unbiased transcriptome analysis of the post-mortem brain tissue of COVID-19 patients did not succeed in detecting molecular traces of SARS-CoV-2 virus in the brain parenchyma8 negating direct SARS-CoV-2 infection into the CNS parenchyma. More recently, it was reported that intravenously administered radiolabeled S1 subunit of SARS-CoV-2 spike protein (S1 protein) can translocate into brain parenchyma by crossing the blood–brain barrier9. Therefore, this suggests the possibility that S1 proteins translocated into the brain parenchyma may affect brain functions, which might underlie the neurological or psychiatric symptoms of COVID-19 patients. The possibility was examined by introducing S1 proteins into mouse brains. We showed that the injection of S1 protein into mouse hippocampus induced cognitive deficits and anxiety-like behaviors. As mechanisms, we found that SARS-CoV-2 S1 protein exerted non-cell autonomous hippocampal neuronal cell death by inducing interleukin-1 beta (IL-1β) expression from glial cells

Sunday, November 7, 2021

Spike protein inhibits DNA repair.

from the Abstract

Clinical studies have indicated that patients with severe COVID–19 exhibit delayed and weak adaptive immune responses; however, the mechanism by which SARS–CoV–2 impedes adaptive immunity remains unclear. Here, by using an in vitro cell line, we report that the SARS–CoV–2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines. 

If you'd prefer a short lesson on how this occurs, Dr. Mobeen Seyd provides a great service.