Showing posts with label — SouthPaws (@SouthPaws382131) March 1. Show all posts
Showing posts with label — SouthPaws (@SouthPaws382131) March 1. Show all posts

Friday, March 1, 2024

SASHA LATYPOVA: if you were claiming a specific mechanism of action, you need to demonstrate it. And that's in the manufacturing documentation . . . None of this was done. Not only that, we later learned that they faked their Western blots


There was no evidence that they were making that Spike protein that they were claiming that they were making ever.  And they have never demonstrated that they can make it actually.  There's not a single scientific publication.  In fact, there was recently a publication showing the opposite, showing that they are making aberrant proteins because of that pseudouridine substitution apparently it creates these skipping the frames and they're making different proteins every time.  So how is it that the claimed mechanism of action the most important part claimed mechanism of action is oh we're going to give you this mRNA code and your cells are going to make these specific Spike protein with the specific virus or variance and now they have these boosters for variants how do you prove that you can do it if you've never demonstrated that you can make one consistent Spike protein?

00:52. So they were measuring instead the amount of antibodies right is that what you're talking about they're measuring the antibodies but never the spike protein in the blood of a human?

01:00. Right, so as a manufacturer, if you were claiming a specific mechanism of action, you need to demonstrate it.  And that's in the manufacturing documentation, so they were supposed to make, for example, a cell assay showing that at least in the cell, ideally, you would do it in an animal model, but at least in some cell lines show that you can actually by putting this mRNA in there, it will make the specific spike protein this Wuhan, whatever you're calling the spike protein, or for Omicron or for Delta, they're claiming all sorts of variants now.  None of this was done.  Not only that, we later learned that they faked their Western blots, and Western blots is one of the assays that you do to characterize those spike proteins that you're making.  Well, guess what?  They faked them. They just computer-generated them.  They never produced the real images and even the computer-generated ones we're showing spike proteins of different weight, not the Wuhan one.  It's as awful as it gets.  In the U.S., it's completely disregarded as I'll explain the legal framework.  But in EMA because of the conditional marketing approval, this was a condition of their approval that they will eventually submit that data to the regulators.  They never did.  Never did.  They just abandoned that requirement altogether.