KEVIN MCKERNAN: Psilocybin has a much larger therapeutic index than IVM.

I suspect your trolling the means.. But in case you’re not, psilocybin has a much larger therapeutic index than IVM. The therapeutic index (TI) is a ratio that compares the toxic dose (usually TD50 or LD50) to the effective dose (ED50) of a drug. A higher TI means a wider margin of safety. Here’s a side-by-side comparison: Psilocybin •ED50 (effective dose): ~6–10 mg orally in humans •LD50 (lethal dose): ~280 mg/kg in rats (oral) •Estimated human LD50 extrapolated: >17,000 mg for a 70 kg adult (very high) •Therapeutic Index: >1000 •Notes: •Extremely low toxicity; no known fatal overdose from pure psilocybin. •Primary risks are psychological (e.g., panic, psychosis) rather than physiological. Ivermectin •ED50 (effective antiparasitic dose): ~150–400 µg/kg (human standard dose) •LD50 (lethal dose): ~10–30 mg/kg in mammals •Therapeutic Index: ~50–100 depending on species and route •Notes: •High safety margin in antiparasitic use. •Neurotoxicity becomes a concern at very high doses or in certain dog breeds lacking MDR1 gene; rare in humans at therapeutic levels. Summary •Psilocybin has a much higher therapeutic index (>1000), reflecting its extremely low physical toxicity. •Ivermectin has a high but lower TI (~50–100), still considered safe within prescribed doses.

— Kevin McKernan (@Kevin_McKernan) May 10, 2025

I suspect your trolling the means. But in case you’re not, psilocybin has a much larger therapeutic index than IVM. The therapeutic index (TI) is a ratio that compares the toxic dose (usually TD50 or LD50) to the effective dose (ED50) of a drug. A higher TI means a wider margin of safety. Here’s a side-by-side comparison: PSILOCYBIN •ED50 (effective dose): ~6–10 mg orally in humans •LD50 (lethal dose): ~280 mg/kg in rats (oral) •Estimated human LD50 extrapolated: >17,000 mg for a 70 kg adult (very high) •Therapeutic Index: >1000 •Notes: •Extremely low toxicity; no known fatal overdose from pure psilocybin. •Primary risks are psychological (e.g., panic, psychosis) rather than physiological. IVERMECTIN •ED50 (effective antiparasitic dose): ~150–400 µg/kg (human standard dose) •LD50 (lethal dose): ~10–30 mg/kg in mammals •Therapeutic Index: ~50–100 depending on species and route •Notes: •High safety margin in antiparasitic use. •Neurotoxicity becomes a concern at very high doses or in certain dog breeds lacking MDR1 gene; rare in humans at therapeutic levels. SUMMARY •Psilocybin has a much higher therapeutic index (>1000), reflecting its extremely low physical toxicity. 

•Ivermectin has a high but lower TI (~50–100), still considered safe within prescribed doses.