Friday, February 28, 2025

SHUANGSHI WEI, ET AL: [Egg yolks] showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro

"Chicken Egg Yolk Antibodies (IgYs) Block the Binding of Multiple SARS-CoV-2 spike protein variants to Human ACE2 [receptors]," Shuangshi Wei, et al., January 2021.

This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.

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