NIACIN HELPS CLEAR INFLAMMATION

This is 3 hours long. Who has the time?  Listen to what you can, and you will learn a lot about the importance of Niacin and its flush and how it helps to expel toxins from the cells.  

The Niacin flush creates a thermogenesis response.  Your body needs energy to detox.  Inflammation over accumulates which uses up the Butyrate into down-regulation into silencing of this Niacin GPR 109A receptor.  Niacin should be used for Parkinson's too.

The niacin flush is anti-inflammation, a cooling down, a release if kinetic heat energy out of the system. It's not as hot there as it was before, The flush is literally blood-clot killing.  This is the first level of anti-inflammatory actions. 

If you're not tackling the inflammation, oxidative stress, if you don't clean that out with homeostasis metabolism that excess energy from the cells, it's going to accumulate and the more the cells fail.  With COVID, it's a rapid, complete phenotypic shift of energy.  The Niacin receptor informs how much Niacin you need.  Could be 10 years of little mini-COVIDs or one big COVID exposure.  If you don't tackle that inflammation, it leads to cellular failure.  If you want to get the inflammation out of your cells, you can only get out ehat it is signaling through its receptor. It's limited by the cells failing and not being able to signal as much.  

11:00. You talked about the first flush is so intense because

Where is the butyrate coming from, the colon rather than being systemically activated?  Rather than immune activation, you have butyrate being used as the primary tool.  Colonic Butyrate fuels the whole endothelium system.  Modulates systemic inflammation by the GPR 109A receptor. Intestinal homeostasis keeps butyrate in abundance.  Probiotics maintain GPR 109A in abundance.  Accumulative insults and over-accumulation of energy degrade butyrate, GPR 109A receptors, gut lining, etc. 

Kats' emphasis on niacin is different that what the mainstream says about niacin.  You need Niacin to make NAD, necessary for energy metabolism.  Molecules like NAADP get brushed into a secondary or tertiary line of importance.  GPR109A activates the flushing response.  People are trying to boost their NAD levels.  Institute of Medicine on niacin where they established the RDAs, Kats initially thought that the niacin flush was niacin getting into the cells and causing exfoliation of inflammation out of the body.  A fever response is trying to burn off fat of a stearified cholesterol.  Also when you exercise and release energy bonds that counter out free radicals and kinetic energy that goes downstream and you push it out, and that is what Niacin is doing.  Exercise allows you to exorcise excess energy out of the body.

  

Dietician, Jennifer Depew, explains the importance of niacin and references Dr. Kats's site.

Niacin (nicotinic acid) Protocol against COVID-19, shared with permission of the author, Dmitry Kats, Ph.D. *His website:  niacincurescovid.com.  *The apples and antihistamines can decrease the flush effect if it seems like too much and should be fine at other times of the day, than taken with or shortly after the niacin dose.

I like what Dr. Kats says here on his website,

Efficiently restores health from remnant damage in long-haulers.  Reduces inflammation, cholesterol, aches & pains.  Increases blood oxygen levels, increases energy, Help heal lung tissue, vessels, and much more. 

FYI, Kats does point you to his other website, Hom3ostasis.com.  There he offers a membership with a forum where you can comment and leave posts and whatnot.  The beginning price is worth it.  Price to clicking on the "Getting Started" button, check out his links first to get a lay of the land.  Kats says at the 40:25 mark to look up "kidney-niacin research."  Not great or specific direction, but okay.  I knew about kidney and baking soda, or sodium bicarbonate, but never heard about how Niacin AND Baking Soda have a powerful effect on the kidneys.  I thought his point about how COVID was exhausting the kidneys was good.  I am just having a hard time figuring out where he's coming from: purely nutritional compound, or does he have some special insight about COVID-19 that I've not heard yet?  I'll have to keep searching his sites.  

This was interesting, 

Supplementation with daily low-dose niacin reliably reverses a large amount of the functional loss. This simple treatment is effective and critically important. Mortality rates with CKD are striking, as the 5-year survival rate for patients doing long-term dialysis is 35% compared to 25% in those with diabetes [T2DM] in the USA. 

I have now personally observed more than 25 documented cases of individuals having their CKD progression not only halted but reversed with the addition of 3 to 5 cents worth of niacin, per day (with 1.8-2.4g/day sodium-bicarbonate with/without 250-500mg/day calcium-carbonate). 

I did not know this about phosphorous.

I was lucky to have been mentored by Dr. William F. Finn. [46]. Even if a patient has not already been scheduled for dialysis, he explained, and especially if they are currently on dialysis, you must get the serum phosphorus down. Excessive phosphorous is toxic to the kidneys as well as virtually every organ system and the entire body. [47,48] Phosphorus is a primary initiator of vascular calcification, among several other pathologies. If the kidneys start to lose a certain fraction of their normal function, the body can no longer efficiently clear phosphorous. When phosphorous serum levels reach abnormal levels, then you begin to saturate the tissues. Then phosphorous binds to calcium and it's the phosphorous, not the calcium that starts the pathology leading to calcium phosphate stones. 

 

Obesity correlates with a reduction in dietary fat

Check this article out! I added BHB to my daily regimen a couple weeks ago to treat a genetic condition; been reading a LOT about it since its completely changed my life.. I believe these two will drastically help anyone with long covid!!  https://t.co/9Jo0oXdRv7

— Heebs (@Heberhall1) November 25, 2021

Very interesting dietary points to be had here.  One, fat is important for the brain--for brain energy needs and for the building blocks to support the brain's development.  Hello!

Dietary fat is said to have played a critical role in the evolution of the human brain since the brain needs a dense calorie load to sustain it energetically but also needs the fat building blocks to support its development [6]. This dogma certainly continues today based on research that shows that docosahexaenoic acid (DHA) and other fats play a crucial role in neural tissue growth and function. Anomalies in fat metabolism or shortfalls in dietary fats can interfere with brain development and function [7]. In fact, experts assert that a move away from the higher fat diet might be more the cause of the North American metabolic syndrome epidemic.

This point was interesting--that obesity correlates with a reduction in dietary fat.  Therefore, if someone is fat, they should eat fats to reduce their weight load.  Since this article is about butyrate, one should begin including more butter into their diet.  

Statistical review of US macronutrient consumption today reveals an increase in the incidence of obesity correlating with the reduction in dietary fat; which results consequently in increased intake of carbohydrate foods [8]. Somewhere in the middle closer to the low carbohydrate end of the diet is a happy healthy medium where processed carbohydrate sources are limited and healthy fat is loaded but a good supply of fresh vegetables (low glycemic index carbohydrate sources) still comprises a significant component of the diet [9]. In particular, it is speculated that a lower overall intake of carbohydrate sources is the healthier way to go with these choices making up, for the major part, those of a lower glycemic load and higher fiber constitution. 

And a high-fat, low-carbohydrate diet, also known as the Ketogenic Diet, has profound effects on your health.  This was fascinating, 

The low-carbohydrate high-fat diet (LCHFD) has cycled in and out of popularity . . . as a therapeutic program to treat metabolic syndrome," such as epilepsy, cognitive deficit, neurological disorders like Alzheimer's disease where it's shown to downregulate deleterious amyloid protein . . . and weight loss.  Incredible. 

It is well understood that dietary restriction in the form of calorie or carbohydrate deprivation is conducive to ketogenesis and serum ketone elevation [10]. The low-carbohydrate high-fat diet (LCHFD) has cycled in and out of popularity for decades as a therapeutic program to treat metabolic syndrome [11]; epilepsy [12]; cognitive deficit [13]; neurological disorders like Alzheimer's disease where its shown to downregulate deleterious amyloid protein [14]; as an activator of uncoupling protein activity for thermogenesis [15]; and weight loss [16]. The ketogenic diet is far from a novel concept. The understanding that this dietary protocol can effectively reduce seizure frequency [17] and help treat even drug-resistant epilepsy [18] was established as far back as the 1920's [19, 20].  CJ pointed out the better fats to have in one's diets.  For years, I consumed olive oil, but difficult to find consistently good EVOO.

This really is a must-read article.  Continue reading . . . .

CJ pointed out the better fats to have in one's diet.  For years, I consumed olive oil, but difficult to find consistently good EVOO. He recommends XV Olive Oil, grass-fed butter, ghee, avocado oil. I should have asked him which brands are preferable. Per Mark Sisson's recommendation, always select an olive oil brand nearest you. For example, if you live in Los Angeles, CA, not the best decision to get Greek olive oil, even though the country is known for its olive oil. Ditto for Italy. Instead, pick up a locally manufactured olive oil in and around Los Angeles, like Santa Barbara, Temecula Valley, so forth. This California brand blends several different kinds of olive oils. I think my favorite, or at least one that was consistent, was Dr. Barry Sears' olive oil that had a nice peppery aftertaste. His oil is sourced from Umbria, Italy, which contradicts the recommendation of sourcing it locally. But I liked it.