P53 protects telomeres https://t.co/TnPyaNNWOF. @Parsifaler
— Jennifer Depew, RD (@deNutrients) August 19, 2021
Telomeres
cap the ends of chromosomes and are crucial for genome stability. The p53protein (TP53) is a vital tumor suppressor, activating the transcription of
numerous genes in response to cell stress. We reported that direct binding of
p53 at human subtelomeres corresponds with local transcription activation and
enhanced telomere stability in the presence of DNA damage.
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