The reason is simple. Melatonin reduces cone sensitivity but increase rod sensitivity to light.
— Doris Loh (@DorissLoh) May 17, 2023
Why does that matter? It is a story about reducing ATP energy requirements. That means using MEL will get you more vision for less ATP.
Brilliant, is it not? https://t.co/0FtHwgSPoK pic.twitter.com/GXCi7mrvnf
GET NUTRITION FROM FARM-DIRECT, CHEMICAL-FREE, UNPROCESSED ANIMAL PROTEIN. SUPPLEMENT WITH VITAMINS. TAKE EXTRA WHEN NECESSARY
Tuesday, August 5, 2025
DORIS LOH: Melatonin reduces cone sensitivity but increases rod sensitivity to light. Why does that matter? It is a story about reducing ATP energy requirements. That means using MEL will get you more vision for less ATP.
Tuesday, October 4, 2022
MELATONIN: For neuro-protection, not just sleep inducement, a lot melatonin is required: 50-100mg.
https://t.co/T6h5DJ9EeB
— DCGreenZone1 (@DCGreenZone) October 4, 2022
This article reviews the protective role of melatonin with mechanistic insights against mitochondrial diseases and sugg new avenues 4 safe and effective tx modalities against these devastating neurodegenerative diseases. Future insights are also discussed.
Below are the sections of each abstract that I thought were interesting and helpful.
ABSTRACT #1
Melatonin is selectively taken up by mitochondrial membranes, a function not shared by other anti-oxidants, and thus has emerged as a major potential therapeutic tool for treating neurodegenerative disorders. Multiple in vitro and in vivo experiments have shown the protective role of melatonin for preventing oxidative stress-induced mitochondrial dysfunction seen in experimental models of PD, AD, and HD. https://pubmed.ncbi.nlm.nih.gov/26087000/
For neuro-protection, not just sleep inducement, a lot melatonin is required: 50-100mg.
ABSTRACT #2
Both in vitro and in vivo, melatonin was effective to prevent oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of AD, PD and HD. These effects are seen at doses 2-3 orders of magnitude higher than those required to affect sleep and circadian rhythms, both conspicuous targets of melatonin action. Melatonin is selectively taken up by mitochondria, a function not shared by other antioxidants. A limited number of clinical studies indicate that melatonin can improve sleep and circadian rhythm disruption in PD and AD patients. More recently, attention has been focused on the development of potent melatonin analogs with prolonged effects which were employed in clinical trials in sleep-disturbed or depressed patients in doses considerably higher than those employed for melatonin. In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin in the range of 50-100mg/day are needed to assess its therapeutic validity in neurodegenerative disorders. https://pubmed.ncbi.nlm.nih.gov/22391273/
ABSTRACT #3
Melatonin is a tryptophan-derived ancestral molecule evolved in bacteria.
Throughout the aging process melatonin levels tend to reduce and as a manifestation of this, many symptoms in organisms' homeostasis, such as deterioration in adjustment of cellular clocks, are commonly seen. In addition, due to deterioration in mitochondrial integrity and functions, immunity decreases, and lower levels of melatonin renders older individuals to be more susceptible to impaired redox modulation and age-related diseases. https://pubmed.ncbi.nlm.nih.gov/35895186/
Friday, November 27, 2020
"Sleep the night before the test didn’t matter, the week & month before did"
Why sleep is so important for students (and everyone else), as found in this study of an MIT chemistry class:
— Ethan Mollick (@emollick) November 12, 2020
๐The quality of sleep accounted for 25% of the variance in grades!
๐ค Sleep the night before the test didn’t matter, the week & month before did https://t.co/Qitv0zon2Q pic.twitter.com/96054PNFLl
Not only does melatonin improve the quality of sleep as well as duration, it's also been recognized as the only agent to normalize blood pressure if that's a concern for you.
Bill Sardi writes, "Melatonin is the only agent that Dr. Houston has found to work to normalize blood pressure among patients whose blood pressure does not dip at night."
Monday, November 9, 2015
Thanks to Robert Wenzel
Cortisol stops all neurons from developing. Coritsol is that hormone that we produce when we're stressed out, injured, or cannot sleep. If your work situation is producing any of these and your coworkers enjoy watching you being stressed out, it's probably not a good idea to remain at that foul and fetid place. Stress decreases the hippocampus. Wow. So it literally shrinks your brain. That was interesting and horrible.
Monday, July 6, 2015
Keep your feet bare during sleep. Your feet and hands help reduce
your body's temperature. The cooler your temperature the more readily will your body induce sleep.