SAMA HOOLE: If ketosis was dangerous, our ancestors would have died every winter when plant food disappeared.

If ketosis was dangerous, our ancestors would have died every winter when plant food disappeared.

Ice Age Europe: No berries for 6 months. No vegetables. No fruit. Just fatty megafauna.

Your body entering ketosis to burn fat for fuel in the absence of carbohydrates isn't a… pic.twitter.com/nNeRZ6CBun

— Sama Hoole (@SamaHoole) January 15, 2026

If ketosis was dangerous, our ancestors would have died every winter when plant food disappeared. Ice Age Europe: No berries for 6 months. No vegetables. No fruit. Just fatty megafauna. Your body entering ketosis to burn fat for fuel in the absence of carbohydrates isn't a metabolic emergency. It's the default survival mode humans used for hundreds of thousands of years. Imagine the evolutionary pressure if ketosis caused the catastrophic problems modern doctors claim: "Sorry tribe, I know we have unlimited seal blubber and caribou fat, but if we eat it we'll enter ketosis and die. Best to just starve instead." Natural selection would have eliminated anyone whose body couldn't run on fat within one generation. The fact that you exist means your ancestors spent significant portions of their lives in ketosis and thrived. Modern medicine treats this ancient survival mechanism as a pathological state requiring medical intervention. Your body has been doing this successfully since before agriculture existed. But please, continue eating every 3 hours to "keep your blood sugar stable" like humans definitely did for 2.5 million years.

SAMA HOOLE: The populations with highest gout rates aren't eating the most meat. They're drinking the most sugary beverages and eating the most high-fructose corn syrup.

"High meat consumption causes gout from excess uric acid!"

Gout is caused by insulin resistance, not dietary purines.

Yes, meat contains purines that convert to uric acid. But the primary driver of elevated uric acid is fructose consumption and insulin resistance blocking uric…

— Sama Hoole (@SamaHoole) January 15, 2026

"High meat consumption causes gout from excess uric acid!" Gout is caused by insulin resistance, not dietary purines. Yes, meat contains purines that convert to uric acid. But the primary driver of elevated uric acid is fructose consumption and insulin resistance blocking uric acid excretion. Fructose metabolises directly to uric acid in the liver. More fructose equals more uric acid, regardless of purine intake. The populations with highest gout rates aren't eating the most meat. They're drinking the most sugary beverages and eating the most high-fructose corn syrup. When you fix insulin resistance by removing carbs, your kidneys excrete uric acid efficiently again. Carnivores eating pounds of meat daily typically show normal or low uric acid levels because their insulin sensitivity is excellent. Historical gout was called "disease of kings" because wealthy people ate meat AND sugar, drank port wine, and lived sedentary lives. The gout wasn't from the venison. It was from the dessert, alcohol, and sitting around all day. Modern studies show low-carb diets reduce gout attacks despite higher purine intake because fixing insulin resistance matters more than purine content. If dietary purines caused gout independent of metabolic health, carnivores would be crippled. They're not. They're walking around pain-free while people on "balanced diets" are having gout flares from eating "healthy" fruit juice. Your body can handle purines from meat. It can't handle fructose while insulin-resistant. Fix the insulin resistance, the gout disappears. Keep eating sugar, the gout continues regardless of meat intake.

But telling people to stop drinking Coke doesn't generate pharmaceutical revenue like gout medication does.